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Article

Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression

  • Authors:
    • Hitomi Sakai
    • Masayuki Takeda
    • Kazuko Sakai
    • Kazuto Nishio
    • Kazuhiko Nakagawa
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan, Department of Genome Biology, Kindai University Faculty of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan
  • Pages: 175-178
    |
    Published online on: May 21, 2020
       https://doi.org/10.3892/mco.2020.2048
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Abstract

Anorectal melanoma is a rare disease with a poor prognosis and its response to immunotherapy remains poorly studied. The current study reports a case of recurrent anorectal melanoma in a 60‑year‑old woman that has exhibited a durable response to ipilimumab for >2 years. Given that the combination of nivolumab and ipilimumab was not approved for use in unresectable or metastatic melanoma at the time of presentation, the patient was initially treated with nivolumab monotherapy and switched to ipilimumab after nivolumab failure. The tumor was microsatellite stable, had an intermediate tumor mutation burden and was negative for programmed cell death‑ligand‑1 expression. However, the neutrophil‑to‑lymphocyte ratio in peripheral blood remained at <5 throughout the disease course. Although mucosal melanoma is not caused by ultraviolet radiation and has a lower mutation burden than cutaneous melanoma, the present case responded well to immunotherapy. Further evaluation of potential biomarkers for such patients is required.
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1 

Lian B, Cui CL, Zhou L, Song X, Zhang XS, Wu D, Si L, Chi ZH, Sheng XN, Mao LL, et al: The natural history and patterns of metastases from mucosal melanoma: An analysis of 706 prospectively-followed patients. Ann Oncol. 28:868–873. 2017.PubMed/NCBI View Article : Google Scholar

2 

Furney SJ, Turajlic S, Stamp G, Nohadani M, Carlisle A, Thomas JM, Hayes A, Strauss D, Gore M, van den Oord J, et al: Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma. J Pathol. 230:261–269. 2013.PubMed/NCBI View Article : Google Scholar

3 

van Schaik PM, Ernst MF, Meijer HA and Bosscha K: Melanoma of the rectum: A rare entity. World J Gastroenterol. 14:1633–1635. 2008.PubMed/NCBI View Article : Google Scholar

4 

Chang AE, Karnell LH and Menck HR: The national cancer data base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade. The American college of surgeons commission on cancer and the American cancer society. Cancer. 83:1664–1678. 1998.PubMed/NCBI View Article : Google Scholar

5 

Haanen JBAG: Converting cold into hot tumors by combining immunotherapies. Cell. 170:1055–1056. 2017.PubMed/NCBI View Article : Google Scholar

6 

Brady MS, Kavolius JP and Quan SH: Anorectal melanoma. A 64-year experience at memorial sloan-kettering cancer center. Dis Colon Rectum. 38:146–151. 1995.PubMed/NCBI View Article : Google Scholar

7 

Perez DR, Trakarnsanga A, Shia J, Nash GM, Temple LK, Paty PB, Guillem JG, Garcia-Aguilar J, Bello D, Ariyan C, et al: Locoregional lymphadenectomy in the surgical management of anorectal melanoma. Ann Surg Oncol. 20:2339–2344. 2013.PubMed/NCBI View Article : Google Scholar

8 

Hicks CW, Pappou EP, Magruder JT, Gazer B, Fang S, Wick EC, Gearhart SL, Ahuja N and Efron JE: Clinicopathologic presentation and natural history of anorectal melanoma: A case series of 18 patients. JAMA Surg. 149:608–611. 2014.PubMed/NCBI View Article : Google Scholar

9 

Hillenbrand A, Barth TF, Henne-Bruns D and Formentini A: Anorectal amelanotic melanoma. Colorectal Dis. 10:612–615. 2008.PubMed/NCBI View Article : Google Scholar

10 

Malaguarnera G, Madeddu R, Catania VE, Bertino G, Morelli L, Perrotta RE, Drago F, Malaguarnera M and Latteri S: Anorectal mucosal melanoma. Oncotarget. 9:8785–8800. 2018.PubMed/NCBI View Article : Google Scholar

11 

D'Angelo SP, Larkin J, Sosman JA, Lebbé C, Brady B, Neyns B, Schmidt H, Hassel JC, Hodi FS, Lorigan P, et al: Efficacy and safety of nivolumab alone or in combination with ipilimumab in patients with mucosal melanoma: A pooled analysis. J Clin Oncol. 35:226–235. 2017.PubMed/NCBI View Article : Google Scholar

12 

Del Vecchio M, Di Guardo L, Ascierto PA, Grimaldi AM, Sileni VC, Pigozzo J, Ferraresi V, Nuzzo C, Rinaldi G, Testori A, et al: Efficacy and safety of ipilimumab 3 mg/kg in patients with pretreated, metastatic, mucosal melanoma. Eur J Cancer. 50:121–127. 2014.PubMed/NCBI View Article : Google Scholar

13 

Postow MA, Luke JJ, Bluth MJ, Ramaiya N, Panageas KS, Lawrence DP, Ibrahim N, Flaherty KT, Sullivan RJ, Ott PA, et al: Ipilimumab for patients with advanced mucosal melanoma. Oncologist. 18:726–732. 2013.PubMed/NCBI View Article : Google Scholar

14 

Büttner R, Longshore JW, López-Ríos F, Merkelbach-Bruse S, Normanno N, Rouleau E and Penault-Llorca F: Implementing TMB measurement in clinical practice: Considerations on assay requirements. ESMO Open. 4(e000442)2019.PubMed/NCBI View Article : Google Scholar

15 

Hugo W, Zaretsky JM, Sun L, Song C, Moreno BH, Hu-Lieskovan S, Berent-Maoz B, Pang J, Chmielowski B, Cherry G, et al: Genomic and transcriptomic features of response to Anti-PD-1 therapy in metastatic melanoma. Cell. 165:35–44. 2016.PubMed/NCBI View Article : Google Scholar

16 

Van Allen EM, Miao D, Schilling B, Shukla SA, Blank C, Zimmer L, Sucker A, Hillen U, Foppen MHG, Goldinger SM, et al: Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science. 350:207–211. 2015.PubMed/NCBI View Article : Google Scholar

17 

Snyder A, Makarov V, Merghoub T, Yuan J, Zaretsky JM, Desrichard A, Walsh LA, Postow MA, Wong P, Ho TS, et al: Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 371:2189–2199. 2014.PubMed/NCBI View Article : Google Scholar

18 

Johnson DB, Frampton GM, Rioth MJ, Yusko E, Xu Y, Guo X, Ennis RC, Fabrizio D, Chalmers ZR, Greenbowe J, et al: Targeted next generation sequencing identifies markers of response to PD-1 blockade. Cancer Immunol Res. 4:959–967. 2016.PubMed/NCBI View Article : Google Scholar

19 

Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, et al: Melanoma genome sequencing reveals frequent PREX2 mutations. Nature. 485:502–506. 2012.PubMed/NCBI View Article : Google Scholar

20 

Hayward NK, Wilmott JS, Waddell N, Johansson PA, Field MA, Nones K, Patch AM, Kakavand H, Alexandrov LB, Burke H, et al: Whole-genome landscapes of major melanoma subtypes. Nature. 545:175–180. 2017.PubMed/NCBI View Article : Google Scholar

21 

Larkin J, Chiarion-Sileni V, Gonzalez R, Grob JJ, Cowey CL, Lao CD, Schadendorf D, Dummer R, Smylie M, Rutkowski P, et al: Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med. 373:23–34. 2015.PubMed/NCBI View Article : Google Scholar

22 

Kaunitz GJ, Cottrell TR, Lilo M, Muthappan V, Esandrio J, Berry S, Xu H, Ogurtsova A, Anders RA, Fischer AH, et al: Melanoma subtypes demonstrate distinct PD-L1 expression profiles. Lab Invest. 97:1063–1071. 2017.PubMed/NCBI View Article : Google Scholar

23 

Taube JM, Anders RA, Young GD, Xu H, Sharma R, McMiller TL, Chen S, Klein AP, Pardoll DM, Topalian SL and Chen L: Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 4(127ra37)2012.PubMed/NCBI View Article : Google Scholar

24 

Dodds TJ, Wilmott JS, Jackett LA, Lo SN, Long GV, Thompson JF and Scolyer RA: Primary anorectal melanoma: Clinical, immunohistology and DNA analysis of 43 cases. Pathology. 51:39–45. 2019.PubMed/NCBI View Article : Google Scholar

25 

Zaragoza J, Caille A, Beneton N, Bens G, Christiann F, Maillard H and Machet L: High neutrophil to lymphocyte ratio measured before starting ipilimumab treatment is associated with reduced overall survival in patients with melanoma. Br J Dermatol. 174:146–151. 2016.PubMed/NCBI View Article : Google Scholar

26 

Cassidy MR, Wolchok RE, Zheng J, Panageas KS, Wolchok JD, Coit D, Postow MA and Ariyan C: Neutrophil to lymphocyte ratio is associated with outcome during ipilimumab treatment. EBioMedicine. 18:56–61. 2017.PubMed/NCBI View Article : Google Scholar

27 

Ferrucci PF, Gandini S, Battaglia A, Alfieri S, Di Giacomo AM, Giannarelli D, Cappellini GC, De Galitiis F, Marchetti P, Amato G, et al: Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab-treated metastatic melanoma patients. Br J Cancer. 112:1904–1910. 2015.PubMed/NCBI View Article : Google Scholar

28 

Ferrucci PF, Ascierto PA, Pigozzo J, Del Vecchio M, Maio M, Antonini Cappellini GC, Guidoboni M, Queirolo P, Savoia P, Mandalà M, et al: Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: Prognostic relevance in metastatic melanoma patients receiving ipilimumab. Ann Oncol. 27:732–738. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Sakai H, Takeda M, Sakai K, Nishio K and Nakagawa K: Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression. Mol Clin Oncol 13: 175-178, 2020.
APA
Sakai, H., Takeda, M., Sakai, K., Nishio, K., & Nakagawa, K. (2020). Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression. Molecular and Clinical Oncology, 13, 175-178. https://doi.org/10.3892/mco.2020.2048
MLA
Sakai, H., Takeda, M., Sakai, K., Nishio, K., Nakagawa, K."Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression". Molecular and Clinical Oncology 13.2 (2020): 175-178.
Chicago
Sakai, H., Takeda, M., Sakai, K., Nishio, K., Nakagawa, K."Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression". Molecular and Clinical Oncology 13, no. 2 (2020): 175-178. https://doi.org/10.3892/mco.2020.2048
Copy and paste a formatted citation
x
Spandidos Publications style
Sakai H, Takeda M, Sakai K, Nishio K and Nakagawa K: Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression. Mol Clin Oncol 13: 175-178, 2020.
APA
Sakai, H., Takeda, M., Sakai, K., Nishio, K., & Nakagawa, K. (2020). Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression. Molecular and Clinical Oncology, 13, 175-178. https://doi.org/10.3892/mco.2020.2048
MLA
Sakai, H., Takeda, M., Sakai, K., Nishio, K., Nakagawa, K."Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression". Molecular and Clinical Oncology 13.2 (2020): 175-178.
Chicago
Sakai, H., Takeda, M., Sakai, K., Nishio, K., Nakagawa, K."Long‑term response to ipilimumab after nivolumab failure in a case of anorectal melanoma with an intermediate tumor mutation burden and negative for PD‑L1 expression". Molecular and Clinical Oncology 13, no. 2 (2020): 175-178. https://doi.org/10.3892/mco.2020.2048
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