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Article

Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment

  • Authors:
    • Tomohiro Sugiyama
    • Kenta Makino
    • Yukiko Fukui
    • Hiromitsu Kinoshita
    • Akira Miki
    • Shigeki Uchida
    • Michihiko Tsubono
    • Yasushi Adachi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Toyooka Hospital, Toyooka, Hyogo 668‑0065, Japan, Department of Clinical Pathology, Toyooka Hospital, Toyooka, Hyogo 668‑0065, Japan
  • Pages: 216-220
    |
    Published online on: June 2, 2020
       https://doi.org/10.3892/mco.2020.2054
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Abstract

Incidental gallbladder carcinoma (IGC), defined as unexpected malignancy identified in the surgical gallbladder specimen of a cholecystectomy performed for a benign diagnosis, can be difficult to suspect preoperatively. Furthermore, there are valid clinical reasons to defer reoperation for additional resection, particularly in elderly patients. The present study aimed to determine the long‑term outcomes and prognostic factors associated with recurrence in patients with IGC. The medical records of 678 patients who underwent cholecystectomy at Toyooka Hospital between September 2011 and November 2017 were reviewed. The cases identified to be IGC were retrospectively analyzed to determine patient and histopathological characteristics, surgical details, long‑term outcomes and factors associated with cancer recurrence. A total of 22 patients were diagnosed with gallbladder carcinoma following cholecystectomy by histopathological examination, and 12 of these were identified to be IGC. The median age was 80 years (range 70‑89 years). Although 6 of the 12 patients with IGC had stage pT2 or pT3 tumors, only 1 patient underwent additional resection. Recurrence occurred in 3 of the 8 patients who did not undergo additional resection and were available for long‑term follow‑up. Recurrence was not associated with the extent of tumor invasion but may be associated with other histopathological findings, preoperative treatment history and risk factors for recurrence. Furthermore, long‑term survival was observed in patients with pT2 and pT3 tumors who did not undergo additional resection. Recurrence was not associated with the extent of tumor invasion but may be associated with other histopathological findings, preoperative treatment history, and risk factors for recurrence. Furthermore, long‑term survival was observed in patients with pT2 and pT3 tumors who did not undergo additional resection. Even if it is a progressive IGC case, appropriate preoperative treatment or cholecystectomy without persistence of the carcinoma cell, based on a preoperative image evaluation and a postoperative histopathological examination, may greatly influence the long‑term prognosis of IGC.
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Copy and paste a formatted citation
Spandidos Publications style
Sugiyama T, Makino K, Fukui Y, Kinoshita H, Miki A, Uchida S, Tsubono M and Adachi Y: Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment. Mol Clin Oncol 13: 216-220, 2020.
APA
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S. ... Adachi, Y. (2020). Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment. Molecular and Clinical Oncology, 13, 216-220. https://doi.org/10.3892/mco.2020.2054
MLA
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S., Tsubono, M., Adachi, Y."Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment". Molecular and Clinical Oncology 13.2 (2020): 216-220.
Chicago
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S., Tsubono, M., Adachi, Y."Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment". Molecular and Clinical Oncology 13, no. 2 (2020): 216-220. https://doi.org/10.3892/mco.2020.2054
Copy and paste a formatted citation
x
Spandidos Publications style
Sugiyama T, Makino K, Fukui Y, Kinoshita H, Miki A, Uchida S, Tsubono M and Adachi Y: Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment. Mol Clin Oncol 13: 216-220, 2020.
APA
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S. ... Adachi, Y. (2020). Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment. Molecular and Clinical Oncology, 13, 216-220. https://doi.org/10.3892/mco.2020.2054
MLA
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S., Tsubono, M., Adachi, Y."Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment". Molecular and Clinical Oncology 13.2 (2020): 216-220.
Chicago
Sugiyama, T., Makino, K., Fukui, Y., Kinoshita, H., Miki, A., Uchida, S., Tsubono, M., Adachi, Y."Long‑term outcomes of incidental gallbladder carcinoma without additional resection: A single institution experiment". Molecular and Clinical Oncology 13, no. 2 (2020): 216-220. https://doi.org/10.3892/mco.2020.2054
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