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Molecular and Clinical Oncology
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August-2020 Volume 13 Issue 2

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Article

A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival

  • Authors:
    • Alannah Smrke
    • Jeremy Hamm
    • Anand Karvat
    • Christine Simmons
    • Amirrtha Srikanthan
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, BC Cancer, Vancouver Centre, Vancouver, BC V5Z4E6, Canada, Department of Cancer Surveillance Outcomes, BC Cancer, Vancouver Centre, Vancouver, BC V5Z4E6, Canada, Department of Radiation Oncology, BC Cancer‑Surrey, Surrey, BC V3V1Z2, Canada, Division of Medical Oncology, Ottawa Hospital Cancer Centre, Ottawa, ON K1H8L6, Canada
  • Pages: 179-185
    |
    Published online on: June 2, 2020
       https://doi.org/10.3892/mco.2020.2055
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Abstract

Angiosarcoma is a subset of soft-tissue sarcomas with poor 5‑year survival rate. Given its rarity, limited large cohort data is available for this disease. Therefore, the present study evaluated data from patients with angiosarcoma treated at a provincial Institution (BC Cancer) to determine potential modifiable predictors of survival. A retrospective review of patients across British Columbia (Canada) was conducted at the Sarcoma Outcome Unit of BC Cancer from January 1, 1969 to September 19, 2017. Cox proportional hazard models were used to calculate hazard ratios (HR) for the overall survival (OS) and progression free survival (PFS) of patients. A total of 145 patients with angiosarcoma were identified, of which 68 were metastatic/unresectable at presentation. Of the 145 patients included, 38 received chemotherapy, with 15 receiving taxane. A single patient received chemotherapy in a neoadjuvant setting. Of the resectable patients, 71 had first line surgery and 38 had curative‑intent radiation during their treatment. Of the study cohort, 38 patients received prior radiation for an unrelated cancer and 4 patients had pre‑existing chronic lymphedema. Resectable disease (HR, 0.22; P<0.01), first treatment with either surgery (HR, 0.08; P<0.01), radiation (HR, 0.19; P<0.01) or chemotherapy (HR, 0.22; P<0.01) were predictors of improved OS. First line surgery resulted in improved OS (HR, 0.36; P<0.01) and PFS (HR, 0.48; P<0.01). In addition, OS was positively impacted by the extent of surgery [complete (R0) vs. microscopic residual tumor (R1); HR, 0.26; P<0.01; R0 vs. macroscopic residual tumor (R2); HR, 0.08; P<0.01) resection. Extent of surgery and any radiation treatment were determined to be important predictors of OS. The results also revealed that patient outcome was improved following any treatment compared with supportive care alone. In conclusion, multidisciplinary care is critical for the treatment of patients diagnosed with angiosarcoma.
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1 

Linch M, Miah AB, Thway K, Judson IR and Benson C: Systemic treatment of soft-tissue sarcoma-gold standard and novel therapies. Nat Rev Clin Oncol. 11:187–202. 2014.PubMed/NCBI View Article : Google Scholar

2 

Young RJ, Brown NJ, Reed MW, Hughes D and Woll PJ: Angiosarcoma. Lancet Oncol. 11:983–991. 2010.PubMed/NCBI View Article : Google Scholar

3 

Penel N, Bui BN, Bay J-O, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, et al: Phase II trial of weekly paclitaxel for unresectable angiosarcoma: The ANGIOTAX Study. J Clin Oncol. 26:5269–5274. 2008.PubMed/NCBI View Article : Google Scholar

4 

Schlemmer M, Reichardt P, Verweij J, Hartmann J, Judson I, Thyss A, Hogendoorn PC, Marreaud S, Van Glabbeke M and Blay JY: Paclitaxel in patients with advanced angiosarcomas of soft tissue: A retrospective study of the EORTC soft tissue and bone sarcoma group. Eur J Cancer. 44:2433–2436. 2008.PubMed/NCBI View Article : Google Scholar

5 

Italiano A, Cioffi A, Penel N, Levra MG, Delcambre C, Kalbacher E, Chevreau C, Bertucci F, Isambert N, Blay JY, et al: Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas. Cancer. 118:3330–3336. 2012.PubMed/NCBI View Article : Google Scholar

6 

Buehler D, Rice SR, Moody JS, Rush P, Hafez GR, Attia S, Longley BJ and Kozak KR: Angiosarcoma outcomes and prognostic factors: A 25-year single institution experience. Am J Clin Oncol. 37(473)2014.PubMed/NCBI View Article : Google Scholar

7 

Penel N, Italiano A, Ray-Coquard I, Chaigneau L, Delcambre C, Robin YM, Bui B, Bertucci F, Isambert N, Cupissol D, et al: Metastatic angiosarcomas: Doxorubicin-based regimens, weekly paclitaxel and metastasectomy significantly improve the outcome. Ann Oncol. 23:517–523. 2011.PubMed/NCBI View Article : Google Scholar

8 

Fury MG, Antonescu CR, Van Zee KJ, Brennan ME and Maki RG: A 14-year retrospective review of angiosarcoma: Clinical characteristics, prognostic factors, and treatment outcomes with surgery and chemotherapy. Cancer J. 11:241–247. 2005.PubMed/NCBI View Article : Google Scholar

9 

Skubitz KM and Haddad PA: Paclitaxel and pegylated-liposomal doxorubicin are both active in angiosarcoma. Cancer. 104:361–366. 2005.PubMed/NCBI View Article : Google Scholar

10 

Pawlik TM, Paulino AF, Mcginn CJ, Baker LH, Cohen DS, Morris JS, Rees R and Sondak VK: Cutaneous angiosarcoma of the scalp: A multidisciplinary approach. Cancer. 98:1716–1726. 2003.PubMed/NCBI View Article : Google Scholar

11 

Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, et al: Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 14:1953–1967. 2007.PubMed/NCBI View Article : Google Scholar

12 

Sher T, Hennessy BT, Valero V, Broglio K, Woodward WA, Trent J, Hunt KK, Hortobagyi GN and Gonzalez-Angulo AM: Primary angiosarcomas of the breast. Cancer. 110:173–178. 2007.PubMed/NCBI View Article : Google Scholar

13 

Mark RJ, Poen JC, Tran LM, Fu YS and Juillard GF: Angiosarcoma: A report of 67 patients and a review of the literature. Cancer. 77:2400–2406. 1996.PubMed/NCBI View Article : Google Scholar

14 

Weidema ME, Flucke UE, van der Graaf WTA, Ho VKY and Hillebrandt-Roeffen MHS: Dutch Nationwide Network and Registry of Histo- and Cytopathology (PALGA)-Group, Versleijen-Jonkers YMH, Husson O and Desar IME. Prognostic factors in a large nationwide cohort of histologically confirmed primary and secondary angiosarcomas. Cancers (Basel). 11(E1780)2019.PubMed/NCBI View Article : Google Scholar

15 

Bonvalot S, Rivoire M, Castaing M, Stoeckle E, Le Cesne A, Blay JY and Laplanche A: Primary retroperitoneal sarcomas: A multivariate analysis of surgical factors associated with local control. J Clin Oncol. 27:31–37. 2009.PubMed/NCBI View Article : Google Scholar

16 

Le Cesne A, Ouali M, Leahy MG, Santoro A, Hoekstra H, Hohenberger P, Van Coevorden F, Rutkowski P, Van Hoesel R, Verweij J, et al: Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: Pooled analysis of two STBSG-EORTC phase III clinical trials. Ann Oncol. 25:2425–2432. 2014.PubMed/NCBI View Article : Google Scholar

17 

Gronchi A, Vullo SL, Colombo C, Collini P, Stacchiotti S, Mariani L, Fiore M and Casali PG: Extremity soft tissue sarcoma in a series of patients treated at a single institution: Local control directly impacts survival. Ann Surg. 251:506–511. 2010.PubMed/NCBI View Article : Google Scholar

18 

Young R, Natukunda A, Litière S, Woll P, Wardelmann E and Van Der Graaf W: First-line anthracycline-based chemotherapy for angiosarcoma and other soft tissue sarcoma subtypes: Pooled analysis of eleven European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group trials. Eur J Cancer. 50:3178–3186. 2014.PubMed/NCBI View Article : Google Scholar

19 

Fata F, O'Reilly E, Ilson D, Pfister D, Leffel D, Kelsen DP, Schwartz GK and Casper ES: Paclitaxel in the treatment of patients with angiosarcoma of the scalp or face. Cancer. 86:2034–2037. 1999.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Smrke A, Hamm J, Karvat A, Simmons C and Srikanthan A: A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival. Mol Clin Oncol 13: 179-185, 2020.
APA
Smrke, A., Hamm, J., Karvat, A., Simmons, C., & Srikanthan, A. (2020). A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival. Molecular and Clinical Oncology, 13, 179-185. https://doi.org/10.3892/mco.2020.2055
MLA
Smrke, A., Hamm, J., Karvat, A., Simmons, C., Srikanthan, A."A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival". Molecular and Clinical Oncology 13.2 (2020): 179-185.
Chicago
Smrke, A., Hamm, J., Karvat, A., Simmons, C., Srikanthan, A."A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival". Molecular and Clinical Oncology 13, no. 2 (2020): 179-185. https://doi.org/10.3892/mco.2020.2055
Copy and paste a formatted citation
x
Spandidos Publications style
Smrke A, Hamm J, Karvat A, Simmons C and Srikanthan A: A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival. Mol Clin Oncol 13: 179-185, 2020.
APA
Smrke, A., Hamm, J., Karvat, A., Simmons, C., & Srikanthan, A. (2020). A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival. Molecular and Clinical Oncology, 13, 179-185. https://doi.org/10.3892/mco.2020.2055
MLA
Smrke, A., Hamm, J., Karvat, A., Simmons, C., Srikanthan, A."A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival". Molecular and Clinical Oncology 13.2 (2020): 179-185.
Chicago
Smrke, A., Hamm, J., Karvat, A., Simmons, C., Srikanthan, A."A retrospective review of 145 patients with angiosarcoma: Radiation therapy, extent of resection and chemotherapy are important predictors of survival". Molecular and Clinical Oncology 13, no. 2 (2020): 179-185. https://doi.org/10.3892/mco.2020.2055
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