Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
August-2020 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2020 Volume 13 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation

  • Authors:
    • Fumie Oyama
    • Masayuki Futagami
    • Hiroe Oikiri
    • Anna Takabayashi
    • Asami Akaishi
    • Tomoe Kodama
    • Mami Matsumoto
    • Masahiro Kanamori
    • Maika Oishi
    • Rie Miura
    • Hachidai Hirakawa
    • Yoshihito Yokoyama
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
  • Pages: 169-174
    |
    Published online on: June 3, 2020
       https://doi.org/10.3892/mco.2020.2056
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequently observed treatment‑related adverse effect, particularly associated with taxane‑based chemotherapy, which affects the quality of life of the patients. To date, CIPN has been subjectively evaluated by patients or physicians. Intraepidermal electrical stimulation (IES) may be applied to evaluate the function of small fibers by measuring pain threshold, and assess the degree of diabetic peripheral neuropathy. The aim of the present study was to evaluate CIPN objectively by using IES. The pain threshold measured by IES in patients with gynecological cancer who underwent taxane‑based chemotherapy was compared with the clinical grading scale of peripheral neuropathy (National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0). A total of 57 patients were evaluated (151 measurements). The median age of the patients was 63 years. The number of measurements with clinical grades of 0, 1 and ≥2 was 49, 57 and 45, respectively. The mean pain threshold was 0.1, 0.14 and 0.18 mA for grades 0, 1 and ≥2, respectively. Therefore, the mean pain threshold significantly increased with the progression of the clinical grade. The measurement of pain threshold by using IES may be a reliable indicator for quantitative evaluation of CIPN.
View Figures

Figure 1

Figure 2

View References

1 

Wolf S, Barton D, Kottschade L, Grothey A and Loprinzi C: Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies. Eur J Cancer. 44:1507–1515. 2008.PubMed/NCBI View Article : Google Scholar

2 

Gaballah A, Shafik A, Elhusseiny K and Ashraf M: Chemotherapy-induced peripheral neuropathy in Egyptian patients: Single institution retrospective analysis. Asian Pac J Cancer Prev. 19:2223–2227. 2018.PubMed/NCBI View Article : Google Scholar

3 

Miltenburg NC and Boogerd W: Chemotherapy-induced neuropathy: A comprehensive survey. Cancer Treat Rev. 40:872–882. 2014.PubMed/NCBI View Article : Google Scholar

4 

Pignata S, De Placido S, Biamonte R, Scambia G, Di Vagno G, Colucci G, Febbraro A, Marinaccio M, Lombardi AV, Manzione L, et al: Residual neurotoxicity in ovarian cancer patients in clinical remission after first-line chemotherapy with carboplatin and paclitaxel: The Multicenter Italian Trial in Ovarian cancer (MITO-4) retrospective study. BMC Cancer. 6(5)2006.PubMed/NCBI View Article : Google Scholar

5 

Park SB, Kwok JB, Asher R, Lee CK, Beale P, Selle F and Friedlander M: Clinical and genetic predictors of paclitaxel neurotoxicity based on patient-versus clinician-reported incidence and severity of neurotoxicity in the ICON7 trial. Ann Oncol. 28:2733–2740. 2017.PubMed/NCBI View Article : Google Scholar

6 

National Cancer Institute Division of Cancer Treatment and Diagnosis: Common Terminology Criteria for Adverse Events (CTCAE) v4.0. https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40. Accessed July 15, 2016.

7 

Griffith KA, Couture DJ, Zhu S, Pandya N, Johantgen ME, Cavaletti G, Davenport JM, Tanguay LJ, Choflet A, Milliron T, et al: Evaluation of chemotherapy-induced peripheral neuropathy using current perception threshold and clinical evaluations. Support Care Cancer. 22:1161–1169. 2014.PubMed/NCBI View Article : Google Scholar

8 

Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H, Aaronson NK, Satele DV, Mattar BI, Green NB and Loprinzi CL: The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapy-induced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN20 instrument, N06CA. Support Care Cancer. 20:625–632. 2012.PubMed/NCBI View Article : Google Scholar

9 

Haryani H, Fetzer SJ, Wu CL and Hsu YY: Chemotherapy-induced peripheral neuropathy assessment tools: A systematic review. Oncol Nurs Forum. 44:E111–E123. 2017.PubMed/NCBI View Article : Google Scholar

10 

Doi D, Ota Y, Konishi H, Yoneyama K and Araki T: Evaluation of the neurotoxicity of paclitaxel and carboplatin by current perception threshold in ovarian cancer patients. J Nippon Med Sch. 70:129–134. 2003.PubMed/NCBI View Article : Google Scholar

11 

Matsuoka A, Mitsuma A, Maeda O, Kajiyama H, Kiyoi H, Kodera Y, Nagino M, Goto H and Ando Y: Quantitative assessment of chemotherapy-induced peripheral neurotoxicity using a point-of-care nerve conduction device. Cancer Sci. 107:1453–1457. 2016.PubMed/NCBI View Article : Google Scholar

12 

Sato J, Mori M, Nihei S, Takeuchi S, Kashiwaba M and Kudo K: Objective evaluation of chemotherapy-induced peripheral neuropathy using quantitative pain measurement system (Pain Vision®), a pilot study. J Pharm Health Care Sci. 3(21)2017.PubMed/NCBI View Article : Google Scholar

13 

Gewandter JS, Chaudari J, Ibegbu C, Kitt R, Serventi J, Burke J, Culakova E, Kolb N, Sluka KA, Tejani MA and Mohile NA: Wireless transcutaneous electrical nerve stimulation device for chemotherapy-induced peripheral neuropathy: An open-label feasibility study. Support Care Cancer. 27:1765–1774. 2019.PubMed/NCBI View Article : Google Scholar

14 

Inui K and Kakigi R: Pain perception in humans: Use of intraepidermal electrical stimulation. J Neurol Neurosurg Psychiatry. 83:551–556. 2012.PubMed/NCBI View Article : Google Scholar

15 

Kukidome D, Nishikawa T, Sato M, Igata M, Kawashima J, Shimoda S, Matsui K, Obayashi K, Ando Y and Araki E: Measurement of small fibre pain threshold values for the early detection of diabetic polyneuropathy. Diabet Med. 33:62–69. 2016.PubMed/NCBI View Article : Google Scholar

16 

Suzuki C, Kon T, Funamizu Y, Ueno T, Haga R, Nishijima H, Arai A, Tomiyama M and Baba M: Elevated pain threshold in patients with asymptomatic diabetic neuropathy: An intraepidermal electrical stimulation study. Muscle Nerve. 54:146–149. 2016.PubMed/NCBI View Article : Google Scholar

17 

Vasey PA, Jayson GC, Gordon A, Gabra H, Coleman R, Atkinson R, Parkin D, Paul J, Hay A and Kaye SB: Scottish Gynaecological Cancer Trials Group. Phase III randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as first-line chemotherapy for ovarian carcinoma. J Natl Cancer Inst. 96:1682–1691. 2004.PubMed/NCBI View Article : Google Scholar

18 

Ewertz M, Qvortrup C and Eckhoff L: Chemotherapy-induced peripheral neuropathy in patients treated with taxanes and platinum derivatives. Acta Oncol. 54:587–591. 2015.PubMed/NCBI View Article : Google Scholar

19 

Eckhoff L, Knoop A, Jensen MB and Ewertz M: Persistence of docetaxel-induced neuropathy and impact of quality of life among breast cancer survivors. Eur J Cancer. 51:292–300. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Oyama F, Futagami M, Oikiri H, Takabayashi A, Akaishi A, Kodama T, Matsumoto M, Kanamori M, Oishi M, Miura R, Miura R, et al: Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation. Mol Clin Oncol 13: 169-174, 2020.
APA
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T. ... Yokoyama, Y. (2020). Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation. Molecular and Clinical Oncology, 13, 169-174. https://doi.org/10.3892/mco.2020.2056
MLA
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T., Matsumoto, M., Kanamori, M., Oishi, M., Miura, R., Hirakawa, H., Yokoyama, Y."Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation". Molecular and Clinical Oncology 13.2 (2020): 169-174.
Chicago
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T., Matsumoto, M., Kanamori, M., Oishi, M., Miura, R., Hirakawa, H., Yokoyama, Y."Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation". Molecular and Clinical Oncology 13, no. 2 (2020): 169-174. https://doi.org/10.3892/mco.2020.2056
Copy and paste a formatted citation
x
Spandidos Publications style
Oyama F, Futagami M, Oikiri H, Takabayashi A, Akaishi A, Kodama T, Matsumoto M, Kanamori M, Oishi M, Miura R, Miura R, et al: Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation. Mol Clin Oncol 13: 169-174, 2020.
APA
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T. ... Yokoyama, Y. (2020). Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation. Molecular and Clinical Oncology, 13, 169-174. https://doi.org/10.3892/mco.2020.2056
MLA
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T., Matsumoto, M., Kanamori, M., Oishi, M., Miura, R., Hirakawa, H., Yokoyama, Y."Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation". Molecular and Clinical Oncology 13.2 (2020): 169-174.
Chicago
Oyama, F., Futagami, M., Oikiri, H., Takabayashi, A., Akaishi, A., Kodama, T., Matsumoto, M., Kanamori, M., Oishi, M., Miura, R., Hirakawa, H., Yokoyama, Y."Quantitative evaluation of chemotherapy‑induced peripheral neuropathy by using intraepidermal electrical stimulation". Molecular and Clinical Oncology 13, no. 2 (2020): 169-174. https://doi.org/10.3892/mco.2020.2056
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team