Open Access

Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report

  • Authors:
    • Ryota Otoshi
    • Akimasa Sekine
    • Koji Okudela
    • Masato Asaoka
    • Yozo Sato
    • Satoshi Ikeda
    • Tomohisa Baba
    • Shigeru Komatsu
    • Eri Hagiwara
    • Takashi Ogura
  • View Affiliations

  • Published online on: June 3, 2020     https://doi.org/10.3892/mco.2020.2059
  • Pages: 129-132
  • Copyright: © Otoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present report describes a case of a 68‑year‑old male patient with epidermal growth factor receptor (EGFR)‑mutant non‑small cell lung carcinoma (NSCLC). After cytotoxic chemotherapy of three regimens following 22 months of treatment with EGFR‑tyrosine kinase inhibitors (EGFR‑TKIs), including osimertinib, the patient underwent S‑1 treatment. Despite a decrease in carcinoembryonic antigen 1 month after initiating S‑1 treatment, the patient developed cardiac tamponade. The evaluation of pericardial effusion confirmed small‑cell lung carcinoma (SCLC) transformation. Subsequently, a combination therapy of carboplatin and etoposide was administered, which led to a marked improvement in imaging. In patients with NSCLC who develop pericardial effusion after long‑term EGFR‑TKI therapy, including osimertinib treatment, it is important to investigate whether SCLC transformation occurs or not as a treatable entity.

Related Articles

Journal Cover

August-2020
Volume 13 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S. ... Ogura, T. (2020). Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report. Molecular and Clinical Oncology, 13, 129-132. https://doi.org/10.3892/mco.2020.2059
MLA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13.2 (2020): 129-132.
Chicago
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13, no. 2 (2020): 129-132. https://doi.org/10.3892/mco.2020.2059