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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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August-2020 Volume 13 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report Open Access

Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report

  • Authors:
    • Ryota Otoshi
    • Akimasa Sekine
    • Koji Okudela
    • Masato Asaoka
    • Yozo Sato
    • Satoshi Ikeda
    • Tomohisa Baba
    • Shigeru Komatsu
    • Eri Hagiwara
    • Takashi Ogura
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Kanagawa 236‑0051, Japan, Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236‑0027, Japan
    Copyright: © Otoshi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 129-132
    |
    Published online on: June 3, 2020
       https://doi.org/10.3892/mco.2020.2059
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Abstract

The present report describes a case of a 68‑year‑old male patient with epidermal growth factor receptor (EGFR)‑mutant non‑small cell lung carcinoma (NSCLC). After cytotoxic chemotherapy of three regimens following 22 months of treatment with EGFR‑tyrosine kinase inhibitors (EGFR‑TKIs), including osimertinib, the patient underwent S‑1 treatment. Despite a decrease in carcinoembryonic antigen 1 month after initiating S‑1 treatment, the patient developed cardiac tamponade. The evaluation of pericardial effusion confirmed small‑cell lung carcinoma (SCLC) transformation. Subsequently, a combination therapy of carboplatin and etoposide was administered, which led to a marked improvement in imaging. In patients with NSCLC who develop pericardial effusion after long‑term EGFR‑TKI therapy, including osimertinib treatment, it is important to investigate whether SCLC transformation occurs or not as a treatable entity.
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Copy and paste a formatted citation
Spandidos Publications style
Otoshi R, Sekine A, Okudela K, Asaoka M, Sato Y, Ikeda S, Baba T, Komatsu S, Hagiwara E, Ogura T, Ogura T, et al: Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report. Mol Clin Oncol 13: 129-132, 2020.
APA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S. ... Ogura, T. (2020). Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report. Molecular and Clinical Oncology, 13, 129-132. https://doi.org/10.3892/mco.2020.2059
MLA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13.2 (2020): 129-132.
Chicago
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13, no. 2 (2020): 129-132. https://doi.org/10.3892/mco.2020.2059
Copy and paste a formatted citation
x
Spandidos Publications style
Otoshi R, Sekine A, Okudela K, Asaoka M, Sato Y, Ikeda S, Baba T, Komatsu S, Hagiwara E, Ogura T, Ogura T, et al: Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report. Mol Clin Oncol 13: 129-132, 2020.
APA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S. ... Ogura, T. (2020). Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report. Molecular and Clinical Oncology, 13, 129-132. https://doi.org/10.3892/mco.2020.2059
MLA
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13.2 (2020): 129-132.
Chicago
Otoshi, R., Sekine, A., Okudela, K., Asaoka, M., Sato, Y., Ikeda, S., Baba, T., Komatsu, S., Hagiwara, E., Ogura, T."Small‑cell lung carcinoma transformation of lung adenocarcinoma diagnosed by pericardial effusion: A case report". Molecular and Clinical Oncology 13, no. 2 (2020): 129-132. https://doi.org/10.3892/mco.2020.2059
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