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Article

Expression of miRNA in 5‑FU resistant esophageal cancer

  • Authors:
    • Prasit Mahawongkajit
    • Prakitpunthu Tomtitchong
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Faculty of Medicine, Thammasat University, Amphur Klongluang, Pathumthani 12120, Thailand
  • Pages: 221-227
    |
    Published online on: June 11, 2020
       https://doi.org/10.3892/mco.2020.2070
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Abstract

Fluoropyrimidine plus platinum (FP) are chemotherapeutic drugs that are most frequently used to treat esophageal squamous cell carcinoma (ESCC). However, drug resistance often occurs, and the mechanisms of resistance to 5‑FU is yet to be determined. The role of micro (mi)RNAs has been well established in a variety of human cancers. The aim of the present study was to investigate the expression profile of ESCC, revealing the differential expression between ESCC and 5‑FU resistant ESCC. The establishment of a 5‑FU resistant (5‑FUR) cell lines model provides a way of analyzing the expression of miRNAs in drug resistance. The miRNA expression indicated 50 miRNAs that were upregulated in TE10‑5‑FUR compared with TE10, while 119 miRNAs were downregulated. The TE11‑5‑FUR demonstrated 140 miRNAs were upregulated compared with TE11, which exhibited 12 downregulated miRNAs. Both cell lines share the 2 candidate upregulated miRNAs (miR‑146a and miR‑483‑5p) and 5 downregulated miRNAs (miR‑34a, miR‑141, miR‑200b, miR‑200c and miR‑205). Further studies are required to analyze and evaluate the function of the miRNAs.
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Copy and paste a formatted citation
Spandidos Publications style
Mahawongkajit P and Tomtitchong P: Expression of miRNA in 5‑FU resistant esophageal cancer. Mol Clin Oncol 13: 221-227, 2020.
APA
Mahawongkajit, P., & Tomtitchong, P. (2020). Expression of miRNA in 5‑FU resistant esophageal cancer. Molecular and Clinical Oncology, 13, 221-227. https://doi.org/10.3892/mco.2020.2070
MLA
Mahawongkajit, P., Tomtitchong, P."Expression of miRNA in 5‑FU resistant esophageal cancer". Molecular and Clinical Oncology 13.2 (2020): 221-227.
Chicago
Mahawongkajit, P., Tomtitchong, P."Expression of miRNA in 5‑FU resistant esophageal cancer". Molecular and Clinical Oncology 13, no. 2 (2020): 221-227. https://doi.org/10.3892/mco.2020.2070
Copy and paste a formatted citation
x
Spandidos Publications style
Mahawongkajit P and Tomtitchong P: Expression of miRNA in 5‑FU resistant esophageal cancer. Mol Clin Oncol 13: 221-227, 2020.
APA
Mahawongkajit, P., & Tomtitchong, P. (2020). Expression of miRNA in 5‑FU resistant esophageal cancer. Molecular and Clinical Oncology, 13, 221-227. https://doi.org/10.3892/mco.2020.2070
MLA
Mahawongkajit, P., Tomtitchong, P."Expression of miRNA in 5‑FU resistant esophageal cancer". Molecular and Clinical Oncology 13.2 (2020): 221-227.
Chicago
Mahawongkajit, P., Tomtitchong, P."Expression of miRNA in 5‑FU resistant esophageal cancer". Molecular and Clinical Oncology 13, no. 2 (2020): 221-227. https://doi.org/10.3892/mco.2020.2070
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