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Article

Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT

  • Authors:
    • Fumiya Uchiyama
    • Hidetsugu Nakayama
    • Yuichiro Takeda
    • Wenjie Wang
    • Ryogo Minamimoto
    • Tsuyosi Tajima
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, National Cancer Center for Global Health and Medicine, Tokyo 162‑8655, Japan, Department of Radiation Oncology, National Cancer Center for Global Health and Medicine, Tokyo 162‑8655, Japan, Department of Respiratory Medicine, National Cancer Center for Global Health and Medicine, Tokyo 162‑8655, Japan, Department of Radiation Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 0086‑215000, P.R. China, Department of Nuclear Medicine, National Center for Global Health and Medicine, Tokyo 162‑8655, Japan
  • Article Number: 3
    |
    Published online on: June 18, 2020
       https://doi.org/10.3892/mco.2020.2073
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Abstract

Quantitative CT assessment of patients with pulmonary emphysema is used to measure pulmonary function. The present study evaluated whether the quantitative CT value can accurately estimate the risk of radiation pneumonitis (RP) after stereotactic body radiotherapy (SBRT) for non‑small cell lung cancer (NSCLC) in patients with and without emphysema. A total of 80 patients with stage I NSCLC receiving SBRT at a dose of 50 or 60 Gy in five fractions at our hospital between November 2003 and October 2015 were included in the analysis. A total of 33 (41%) patients were diagnosed with emphysema on CT examination. Dosimetric parameters, quantitative CT percentage value of low attenuation area (LAA%) in the whole lung, and average whole lung CT density values were used to examine the risk of RP. Among the 80 patients, 26 (33%) and 3 (4%) experienced Grade 1 and Grade 2 RP, respectively, during the median observation period of 18.8 (1.8‑106.8) months. The RP rate for patients with a LAA% (<‑910 HU) of ≤25% was significantly higher than that of subjects with LAA% (<‑910 HU) >25% (P=0.037). The RP rate in subjects with an average HU value of >‑790 HU was significantly higher compared with that of patients with ≤‑790 HU (P=0.036). Age (hazard ratio [HR]=2.46; P=0.03) and average HU (HR=3.39; P=0.02) were significantly associated with RP, whereas mean lung dose was not identified to be significant in multivariate analysis. The quantitative CT value was associated with RP after SBRT.
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1 

de-Torres JP, Wilson DO, Sanchez-Salcedo P, Weissfeld JL, Berto J, Campo A, Alcaide AB, García-Granero M, Celli BR and Zulueta JJ: Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD lung cancer screening score. Am J Respir Crit Care Med. 191:285–291. 2015.PubMed/NCBI View Article : Google Scholar

2 

Zhai R, Yu X, Shafer A, Wain JC and Christiani DC: The impact of coexisting COPD on survival of patients with early-stage non-small cell lung cancer undergoing surgical resection. Chest. 145:346–353. 2014.PubMed/NCBI View Article : Google Scholar

3 

Putila J and Guo NL: Combining COPD with clinical, pathological and demographic information refines prognosis and treatment response prediction of non-small cell lung cancer. PLoS One. 9(e100994)2014.PubMed/NCBI View Article : Google Scholar

4 

Brunelli A, Kim AW, Berger KI and Addrizzo-Harris DJ: Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 143 (Suppl 5):e166S–e190S. 2013.PubMed/NCBI View Article : Google Scholar

5 

Palma D, Lagerwaard F, Rodrigues G, Haasbeek C and Senan S: Curative treatment of stage I non-small-cell lung cancer in patients with severe COPD: Stereotactic radiotherapy outcomes and systematic review. Int J Radiat Oncol Biol Phys. 82:1149–1156. 2012.PubMed/NCBI View Article : Google Scholar

6 

Chi A, Liao Z, Nguyen NP, Xu J, Stea B and Komaki R: Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: Clinical implications. Radiother Oncol. 94:1–11. 2010.PubMed/NCBI View Article : Google Scholar

7 

Baker R, Han G, Sarangkasiri S, DeMarco M, Turke C, Stevens CW and Dilling TJ: Clinical and dosimetric predictors of radiation pneumonitis in a large series of patients treated with stereotactic body radiation therapy to the lung. Int J Radiat Oncol Biol Phys. 85:190–195. 2013.PubMed/NCBI View Article : Google Scholar

8 

Barriger RB, Forquer JA, Brabham JG, Andolino DL, Shapiro RH, Henderson MA, Johnstone PA and Fakiris AJ: A dose-volume analysis of radiation pneumonitis in non-small cell lung cancer patients treated with stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 82:457–462. 2012.PubMed/NCBI View Article : Google Scholar

9 

Zhao J, Yorke ED, Li L, Kavanagh BD, Li XA, Das S, Miften M, Rimner A, Campbell J, Xue J, et al: Simple factors associated with radiation-induced lung toxicity after stereotactic body radiation therapy of the thorax: A pooled analysis of 88 studies. Int J Radiat Oncol Biol Phys. 95:1357–1366. 2016.PubMed/NCBI View Article : Google Scholar

10 

Ando K, Sekiya M, Tobino K and Takahashi K: Relationship between quantitative CT metrics and pulmonary function in combined pulmonary fibrosis and emphysema. Lung. 191:585–591. 2013.PubMed/NCBI View Article : Google Scholar

11 

Madani A, Van Muylem A and Gevenois PA: Pulmonary emphysema: Effect of lung volume on objective quantification at thin-section CT. Radiology. 257:260–268. 2010.PubMed/NCBI View Article : Google Scholar

12 

Wang G, Wang L, Ma Z, Zhang C and Deng K: Quantitative emphysema assessment of pulmonary function impairment by computed tomography in chronic obstructive pulmonary disease. J Comput Assist Tomogr. 39:171–175. 2015.PubMed/NCBI View Article : Google Scholar

13 

Schroeder JD, McKenzie AS, Zach JA, Wilson CG, Curran-Everett D, Stinson DS, Newell JD Jr and Lynch DA: Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease. AJR Am J Roentgenol. 201:W460–W470. 2013.PubMed/NCBI View Article : Google Scholar

14 

Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, et al: Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 364:897–906. 2011.PubMed/NCBI View Article : Google Scholar

15 

Hayhurst MD, MacNee W, Flenley DC, Wright D, McLean A, Lamb D, Wightman AJ and Best J: Diagnosis of pulmonary emphysema by computerised tomography. Lancet. 2:320–322. 1984.PubMed/NCBI View Article : Google Scholar

16 

Saito T, Nakayama H, Yamada T, Shiraishi S and Tokuuye K: Is severe emphysema, as defined by quantitative CT measurement, a negative risk factor of radiation fibrosis? Br J Radiol. 91(20170921)2018.PubMed/NCBI View Article : Google Scholar

17 

Takeda A, Kunieda E, Ohashi T, Aoki Y, Oku Y, Enomoto T, Nomura K and Sugiura M: Severe COPD is correlated with mild radiation pneumonitis following stereotactic body radiotherapy. Chest. 141:858–866. 2012.PubMed/NCBI View Article : Google Scholar

18 

Trovo M, Linda A, El Naqa I, Javidan-Nejad C and Bradley J: Early and late lung radiographic injury following stereotactic body radiation therapy (SBRT). Lung Cancer. 69:77–85. 2010.PubMed/NCBI View Article : Google Scholar

19 

Kimura T, Matsuura K, Murakami Y, Hashimoto Y, Kenjo M, Kaneyasu Y, Wadasaki K, Hirokawa Y, Ito K and Okawa M: CT appearance of radiation injury of the lung and clinical symptoms after stereotactic body radiation therapy (SBRT) for lung cancers: Are patients with pulmonary emphysema also candidates for SBRT for lung cancers? Int J Radiat Oncol Biol Phys. 66:483–491. 2006.PubMed/NCBI View Article : Google Scholar

20 

Nyman J, Hallqvist A, Lund JÅ, Brustugun OT, Bergman B, Bergström P, Friesland S, Lewensohn R, Holmberg E and Lax I: SPACE-A randomized study of SBRT vs. conventional fractionated radiotherapy in medically inoperable stage I NSCLC. Radiother Oncol. 121:1–8. 2016.PubMed/NCBI View Article : Google Scholar

21 

Gevenois PA, de Maertelaer V, De Vuyst P, Zanen J and Yernault JC: Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med. 152:653–657. 1995.PubMed/NCBI View Article : Google Scholar

22 

Gevenois PA, Koob MC, Jacobovitz D, De Vuyst P, Yernault JC and Struyven J: Whole lung sections for computed tomographic-pathologic correlations. Modified Gough-Wentworth technique. Invest Radiol. 28:242–246. 1993.PubMed/NCBI View Article : Google Scholar

23 

Müller NL, Staples CA, Miller RR and Abboud RT: ‘Density mask’. An objective method to quantitate emphysema using computed tomography. Chest. 94:782–787. 1988.PubMed/NCBI View Article : Google Scholar

24 

Yamamoto T, Kadoya N, Sato Y, Matsushita H, Umezawa R, Kubozono M, Ishikawa Y, Kozumi M, Takahashi N, Morishita Y, et al: Prognostic value of radiation pneumonitis after stereotactic body radiotherapy: Effect of pulmonary emphysema quantitated using CT images. Clin Lung Cancer. 19:e85–e90. 2018.PubMed/NCBI View Article : Google Scholar

25 

Ishijima M, Nakayama H, Itonaga T, Tajima Y, Shiraishi S, Okubo M, Mikami R and Tokuuye K: Patients with severe emphysema have a low risk of radiation pneumonitis following stereotactic body radiotherapy. Br J Radiol. 88(20140596)2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Uchiyama F, Nakayama H, Takeda Y, Wang W, Minamimoto R and Tajima T: Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT. Mol Clin Oncol 13: 3, 2020.
APA
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., & Tajima, T. (2020). Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT. Molecular and Clinical Oncology, 13, 3. https://doi.org/10.3892/mco.2020.2073
MLA
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., Tajima, T."Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT". Molecular and Clinical Oncology 13.3 (2020): 3.
Chicago
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., Tajima, T."Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT". Molecular and Clinical Oncology 13, no. 3 (2020): 3. https://doi.org/10.3892/mco.2020.2073
Copy and paste a formatted citation
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Spandidos Publications style
Uchiyama F, Nakayama H, Takeda Y, Wang W, Minamimoto R and Tajima T: Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT. Mol Clin Oncol 13: 3, 2020.
APA
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., & Tajima, T. (2020). Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT. Molecular and Clinical Oncology, 13, 3. https://doi.org/10.3892/mco.2020.2073
MLA
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., Tajima, T."Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT". Molecular and Clinical Oncology 13.3 (2020): 3.
Chicago
Uchiyama, F., Nakayama, H., Takeda, Y., Wang, W., Minamimoto, R., Tajima, T."Risk of radiation pneumonitis in patients with emphysema after stereotactic body radiotherapy for non‑small cell lung cancer assessed by quantitative CT". Molecular and Clinical Oncology 13, no. 3 (2020): 3. https://doi.org/10.3892/mco.2020.2073
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