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Article

Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma

  • Authors:
    • Sundaram Subramanian
    • Saroj Kumar Das Majumdar
    • Ghanashyam Biswas
    • Nisarg Joshi
    • Deepak Bunger
    • Mujtaba Ali Khan
    • Imran Ahmad
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, VS Hospital, Madras Cancer Institute, Advanced Cancer Care, Chennai, Tamil Nadu 600031, India, Department of Radiotherapy, All India Institute of Medical Sciences, Bhubaneswar, Odisha 751019, India, Department of Medical Oncology, Sparsh Hospital, Bhubaneswar, Odisha 751007, India, Medical Affairs and Clinical Development, Intas Pharmaceuticals Ltd., Sola, Ahmedabad, Gujarat 380054, India, Jina Pharmaceuticals Inc., Libertyville, IL 60048, USA
  • Article Number: 14
    |
    Published online on: July 6, 2020
       https://doi.org/10.3892/mco.2020.2084
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Abstract

The current retrospective multicenter study evaluated the efficacy and safety of nanosomal docetaxel lipid suspension (NDLS; DoceAqualip) based chemotherapy in patients with gastric and gastroesophageal junction (GEJ) adenocarcinoma. The medical charts of patients with gastric and GEJ adenocarcinoma, who were treated with NDLS (50‑75 mg/m2; 3 weekly cycles) based chemotherapy and followed‑up from April 2014 to September 2018, were analyzed. The study endpoints included overall response rate (ORR) and disease control rate (DCR) in neoadjuvant and metastatic settings. Overall survival (OS) and safety were also evaluated. Of the 43 patients with gastric (n=39) and GEJ (n=4) adenocarcinoma, efficacy evaluation was available in 35 (neoadjuvant, 17/18 patients; metastatic, 18/25 patients). In the neoadjuvant setting, an ORR of 58.82% and a DCR of 94.11% were observed, whereas in the metastatic setting, the ORR was 77.77% and the DCR was 83.33%. In the neoadjuvant setting, at a follow‑up ranging from 0.7 to 41.2 months, the median OS was not reached. In the metastatic setting, the median OS was 31.9 months at a follow‑up ranging from 0.2 to 50.3 months. At least one adverse event (AE) was reported in 24 patients. Anemia, lymphopenia and thrombocytopenia were the most common hematological AEs, while nausea, vomiting and weakness were the most common non‑hematological AEs. NDLS based treatment was well‑tolerated without any new safety concerns. Overall, NDLS‑based chemotherapy was effective and well‑tolerated in the management of gastric and GEJ adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Subramanian S, Majumdar SK, Biswas G, Joshi N, Bunger D, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma. Mol Clin Oncol 13: 14, 2020.
APA
Subramanian, S., Majumdar, S.K., Biswas, G., Joshi, N., Bunger, D., Khan, M.A., & Ahmad, I. (2020). Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma. Molecular and Clinical Oncology, 13, 14. https://doi.org/10.3892/mco.2020.2084
MLA
Subramanian, S., Majumdar, S. K., Biswas, G., Joshi, N., Bunger, D., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma". Molecular and Clinical Oncology 13.3 (2020): 14.
Chicago
Subramanian, S., Majumdar, S. K., Biswas, G., Joshi, N., Bunger, D., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma". Molecular and Clinical Oncology 13, no. 3 (2020): 14. https://doi.org/10.3892/mco.2020.2084
Copy and paste a formatted citation
x
Spandidos Publications style
Subramanian S, Majumdar SK, Biswas G, Joshi N, Bunger D, Khan MA and Ahmad I: Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma. Mol Clin Oncol 13: 14, 2020.
APA
Subramanian, S., Majumdar, S.K., Biswas, G., Joshi, N., Bunger, D., Khan, M.A., & Ahmad, I. (2020). Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma. Molecular and Clinical Oncology, 13, 14. https://doi.org/10.3892/mco.2020.2084
MLA
Subramanian, S., Majumdar, S. K., Biswas, G., Joshi, N., Bunger, D., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma". Molecular and Clinical Oncology 13.3 (2020): 14.
Chicago
Subramanian, S., Majumdar, S. K., Biswas, G., Joshi, N., Bunger, D., Khan, M. A., Ahmad, I."Efficacy and safety of nanosomal docetaxel lipid suspension based chemotherapy in gastric and gastroesophageal junction adenocarcinoma". Molecular and Clinical Oncology 13, no. 3 (2020): 14. https://doi.org/10.3892/mco.2020.2084
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