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Review

Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)

  • Authors:
    • Michael Wotman
    • Maged Ghaly
    • Luke Massaro
    • Tristan Tham
    • Nagashree  Seetharamu
    • Dev Kamdar
    • Douglas Frank
    • Dennis Kraus
    • Sewit Teckie
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY 11549, USA, Department of Otolaryngology‑Head and Neck Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY 11549, USA, Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY 11549, USA
  • Article Number: 24
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    Published online on: July 16, 2020
       https://doi.org/10.3892/mco.2020.2094
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Abstract

The positive predictive value (PPV) of 12‑week post‑therapy FDG‑PET/CT is low in patients with Human Papillomavirus (HPV)‑associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) after treatment with definitive chemoradiation (CRT). Moreover, the diagnostic performance of post‑CRT fine needle aspiration (FNA) in detecting persistent disease is unknown in this population. Given these important shortcomings in post‑CRT treatment assessment, head and neck oncologists are limited in appropriately selecting patients for consolidative neck dissection, which results in over‑treatment of a favorable risk population. Using the PubMed database, we performed a literature review of published series in HPV‑associated OPSCC to investigate potential strategies for improvement of post‑CRT neck assessment. Several different approaches were found, including continued surveillance with PET/CT, delayed timing of restaging PET/CT, initial response evaluation with multimodality or alternative imaging, and detection of circulating HPV DNA. At present, the optimal approach to post‑CRT treatment assessment is unclear; further investigation and incorporation of new technologies and surveillance protocols will be highly beneficial for patients with HPV‑associated OPSCC.
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Reproduced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Head and Neck Cancers V.1.2020. © 2020 National Comprehensive Cancer Network, Inc. All rights reserved. The NCCN Guidelines® and illustrations herein may not be reproduced in any form for any purpose without the express written permission of NCCN. To view the most recent and complete version of the NCCN Guidelines, go online to https://www.nccn.org. The NCCN Guidelines are a work in progress that may be refined as often as new significant data becomes available. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

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Copy and paste a formatted citation
Spandidos Publications style
Wotman M, Ghaly M, Massaro L, Tham T, Seetharamu N, Kamdar D, Frank D, Kraus D and Teckie S: Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Mol Clin Oncol 13: 24, 2020.
APA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D. ... Teckie, S. (2020). Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Molecular and Clinical Oncology, 13, 24. https://doi.org/10.3892/mco.2020.2094
MLA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13.4 (2020): 24.
Chicago
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13, no. 4 (2020): 24. https://doi.org/10.3892/mco.2020.2094
Copy and paste a formatted citation
x
Spandidos Publications style
Wotman M, Ghaly M, Massaro L, Tham T, Seetharamu N, Kamdar D, Frank D, Kraus D and Teckie S: Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Mol Clin Oncol 13: 24, 2020.
APA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D. ... Teckie, S. (2020). Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Molecular and Clinical Oncology, 13, 24. https://doi.org/10.3892/mco.2020.2094
MLA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13.4 (2020): 24.
Chicago
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13, no. 4 (2020): 24. https://doi.org/10.3892/mco.2020.2094
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