Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)

  • Authors:
    • Michael Wotman
    • Maged Ghaly
    • Luke Massaro
    • Tristan Tham
    • Nagashree  Seetharamu
    • Dev Kamdar
    • Douglas Frank
    • Dennis Kraus
    • Sewit Teckie
  • View Affiliations

  • Published online on: July 16, 2020     https://doi.org/10.3892/mco.2020.2094
  • Article Number: 24
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Abstract

The positive predictive value (PPV) of 12‑week post‑therapy FDG‑PET/CT is low in patients with Human Papillomavirus (HPV)‑associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) after treatment with definitive chemoradiation (CRT). Moreover, the diagnostic performance of post‑CRT fine needle aspiration (FNA) in detecting persistent disease is unknown in this population. Given these important shortcomings in post‑CRT treatment assessment, head and neck oncologists are limited in appropriately selecting patients for consolidative neck dissection, which results in over‑treatment of a favorable risk population. Using the PubMed database, we performed a literature review of published series in HPV‑associated OPSCC to investigate potential strategies for improvement of post‑CRT neck assessment. Several different approaches were found, including continued surveillance with PET/CT, delayed timing of restaging PET/CT, initial response evaluation with multimodality or alternative imaging, and detection of circulating HPV DNA. At present, the optimal approach to post‑CRT treatment assessment is unclear; further investigation and incorporation of new technologies and surveillance protocols will be highly beneficial for patients with HPV‑associated OPSCC.
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October-2020
Volume 13 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wotman M, Ghaly M, Massaro L, Tham T, Seetharamu N, Kamdar D, Frank D, Kraus D and Teckie S: Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Mol Clin Oncol 13: 24, 2020
APA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D. ... Teckie, S. (2020). Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review). Molecular and Clinical Oncology, 13, 24. https://doi.org/10.3892/mco.2020.2094
MLA
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13.4 (2020): 24.
Chicago
Wotman, M., Ghaly, M., Massaro, L., Tham, T., Seetharamu, N., Kamdar, D., Frank, D., Kraus, D., Teckie, S."Improving post‑CRT neck assessment in patients with HPV‑associated OPSCC (Review)". Molecular and Clinical Oncology 13, no. 4 (2020): 24. https://doi.org/10.3892/mco.2020.2094