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Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis

  • Authors:
    • Mubarak Al‑Mansour
    • Meteb Al‑Foheidi
    • Ezzeldin Ibrahim
  • View Affiliations / Copyright

    Affiliations: Adult Medical Oncology, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs‑Western Region, Jeddah 21451, Kingdom of Saudi Arabia, Oncology Center, International Medical Center, Jeddah 21451, Kingdom of Saudi Arabia
    Copyright: © Al‑Mansour et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 33
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    Published online on: July 29, 2020
       https://doi.org/10.3892/mco.2020.2103
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Abstract

Diffuse large B‑cell lymphoma (DLBCL) is the most common subtype of non‑Hodgkin's lymphoma (NHL), representing 30% of all lymphoma cases. Within the first 2‑3 years following immunochemotherapy, 30‑40% of patients will experience a relapse or a refractory disease, thereby exhibiting a poor prognosis. High‑dose immunotherapy followed by autologous stem cell transplantation is the standard care for relapsed/refractory (RR) patients with DLBCL. However, >60% of patients are ineligible for a transplant, presenting a therapeutic challenge. Chimeric antigen receptor (CAR) T‑cell therapy has shown promising efficacy in patients with DLBCL, including those with R/R disease. The present study conducted a meta‑analysis that showed highly favorable outcomes [objective response rate (ORR): 69%; complete remission (CR): 49%] in B‑cell NHL patients (n=419) who were treated with second‑generation CAR T cells. The response rate varied in different types of B‑cell NHL. In 306 patients with R/R DLBCL eligible for rate evaluation, the ORR and CR rate mean estimates were 68% [95% confidence interval (CI), 55‑79%] and 46% (95% CI, 38‑54%), respectively. Thus, the findings indicated that immunotherapy with CAR T cells has improved outcomes for patients with R/R DLBCL and other subtypes of B‑cell NHL compared with standard chemotherapy regimens. The study revealed that grade ≥3 anemia (34%) and thrombocytopenia (30%) were the most common adverse effects of CAR T‑cell therapy. Incidence of grade ≥3 cytokine release syndrome and neurotoxicity associated with CAR T‑cell therapy was effectively managed.
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Copy and paste a formatted citation
Spandidos Publications style
Al‑Mansour M, Al‑Foheidi M and Ibrahim E: Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Mol Clin Oncol 13: 33, 2020.
APA
Al‑Mansour, M., Al‑Foheidi, M., & Ibrahim, E. (2020). Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Molecular and Clinical Oncology, 13, 33. https://doi.org/10.3892/mco.2020.2103
MLA
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13.4 (2020): 33.
Chicago
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13, no. 4 (2020): 33. https://doi.org/10.3892/mco.2020.2103
Copy and paste a formatted citation
x
Spandidos Publications style
Al‑Mansour M, Al‑Foheidi M and Ibrahim E: Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Mol Clin Oncol 13: 33, 2020.
APA
Al‑Mansour, M., Al‑Foheidi, M., & Ibrahim, E. (2020). Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis. Molecular and Clinical Oncology, 13, 33. https://doi.org/10.3892/mco.2020.2103
MLA
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13.4 (2020): 33.
Chicago
Al‑Mansour, M., Al‑Foheidi, M., Ibrahim, E."Efficacy and safety of second‑generation CAR T‑cell therapy in diffuse large B‑cell lymphoma: A meta‑analysis". Molecular and Clinical Oncology 13, no. 4 (2020): 33. https://doi.org/10.3892/mco.2020.2103
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