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Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer

  • Authors:
    • Małgorzata Szlendak
    • Robert Sitarz
    • Monika Berbecka
    • Jerzy Mielko
    • Folkert Morsink
    • Ryszard Maciejewski
    • G. Johan A. Offerhaus
    • Wojciech P. Polkowski
  • View Affiliations / Copyright

    Affiliations: Department of Human Anatomy, Medical University of Lublin, Lublin 20‑090, Poland, Department of Surgical Oncology, Medical University of Lublin, Lublin 20‑090, Poland, Department of Pathology, University Medical Center, Utrecht 3508 GA, The Netherlands
    Copyright: © Szlendak et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
    |
    Published online on: August 20, 2020
       https://doi.org/10.3892/mco.2020.2122
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Abstract

In colorectal cancer (CRC), pathological factors that correlate with negative prognosis include, among others, overexpression of cyclooxygenase‑2 (COX‑2) and abundant expression of mucin 1 (MUC1). COX‑2 overexpression may therefore be associated with MUC1 overexpression. The aim of the present study was to investigate the possible correlation between COX‑2 and MUC1 expression and to assess the correlation between their individual expression and the clinicopathological features of patients, paying particular attention to survival. The following data was collected from the 170 patients with CRC included in the present study: Age, sex, tumour localization, disease stage and survival. Tumour samples were immunostained with antibodies against COX‑2 and MUC1. Protein expression was scored, relative to reference staining, and correlated with the clinicopathological data of patients. The results revealed no correlation between the expressions of COX‑2 and MUC1, or with any of the studied clinicopathological variables. In addition, the expression of the two proteins were not associated. Neither of the proteins demonstrated prognostic value for survival. The present study did not confirm a direct relationship between the expressions of COX‑2 and MUC1, or between the expression of either protein and the clinicopathological features of patients, including survival.
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1 

Stewart BW and Wild CP: World Cancer Report 2014. Lyon, France, IARC Press, 2014.

2 

Rawla P, Sunkara T and Barsouk A: Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors. Prz Gastroenterol. 14:89–103. 2019.PubMed/NCBI View Article : Google Scholar

3 

Ohhara Y, Fukuda N, Takeuchi S, Honma R, Shimizu Y, Kinoshita I and Dosaka-Akita H: Role of targeted therapy in metastatic colorectal cancer. World J Gastrointest Oncol. 8:642–655. 2016.PubMed/NCBI View Article : Google Scholar

4 

Kalyan A, Kircher S, Shah H, Mulcahy M and Benson A: Updates on immunotherapy for colorectal cancer. J Gastrointest Oncol. 9:160–169. 2018.PubMed/NCBI View Article : Google Scholar

5 

Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer : Links to genetic instability. Carcinogenesis. 30:1073–1081. 2009.PubMed/NCBI View Article : Google Scholar

6 

Peng L, Zhou Y, Wang Y, Mou H and Zhao Q: Prognostic significance of COX-2 immunohistochemical expression in colorectal cancer: A meta-analysis of the literature. PLoS One. 8(e58891)2013.PubMed/NCBI View Article : Google Scholar

7 

Skierucha M, Milne AN, Offerhaus GJ, Polkowski WP, Maciejewski R and Sitarz R: Molecular alterations in gastric cancer with special reference to the early-onset subtype. World J Gastroenterol. 22:2460–2474. 2016.PubMed/NCBI View Article : Google Scholar

8 

Terada T: An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: II Expression of MUC1, MUC2, MUC5AC, and MUC6 in normal mucosa and in 42 cases. Int J Clin Exp Pathol. 6:613–621. 2013.PubMed/NCBI

9 

Niv Y: MUC1 and colorectal cancer pathophysiology considerations. World J Gastroenterol. 14:2139–2141. 2008.PubMed/NCBI View Article : Google Scholar

10 

Zeng Y, Zhang Q, Zhang Y, Lu M, Liu Y, Zheng T, Feng S, Hao M and Shi H: MC1 predicts colorectal cancer metastasis: A systematic review and meta-analysis of case controlled studies. PLoS One. 10(e0138049)2015.PubMed/NCBI View Article : Google Scholar

11 

Nath S, Roy LD, Grover P, Rao S and Mukherjee P: Mucin 1 regulates Cox-2 gene in pancreatic cancer. Pancreas. 44:909–917. 2015.PubMed/NCBI View Article : Google Scholar

12 

Sitarz R, Leguit RJ, de Leng WW, Polak M, Morsink FM, Bakker O, Maciejewski R, Offerhaus GJ and Milne AN: The COX-2 promoter polymorphism-765 G>C is associated with early-onset, conventional and stump gastric cancers. Mod Pathol. 21:685–690. 2008.PubMed/NCBI View Article : Google Scholar

13 

Eminaga O, Wei W, Hawley SJ, Auman H, Newcomb LF, Simko J, Hurtado-Coll A, Troyer DA, Carroll PR, Gleave ME, et al: MUC1 Expression by immunohistochemistry is associated with adverse pathologic features in prostate cancer: A multi-institutional study. PLoS One. 11(e0165236)2016.PubMed/NCBI View Article : Google Scholar

14 

Kim SH, Ahn BK, Paik SS and Lee KH: Cyclooxygenase-2 expression is a predictive marker for late recurrence in colorectal cancer. Gastroenterol Res Pract. 2018(7968149)2018.PubMed/NCBI View Article : Google Scholar

15 

Kasprzak A, Siodla E, Andrzejewska M, Szmeja J, Seraszek-Jaros A, Cofta S and Szaflarski W: Differential expression of mucin 1 and mucin 2 in colorectal cancer. World J Gastroenterol. 24:4164–4177. 2018.PubMed/NCBI View Article : Google Scholar

16 

Duncan TJ, Watson NF, Al-Attar AH, Scholefield JH and Durrant LG: The role of MUC1 and MUC3 in the biology and prognosis of colorectal cancer. World J Surg Oncol. 5(31)2007.PubMed/NCBI View Article : Google Scholar

17 

Betge J, Schneider NI, Harbaum L, Pollheimer MJ, Lindtner RA, Kornprat P, Ebert MP and Langner C: MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: Expression profiles and clinical significance. Virchows Arch. 469:255–265. 2016.PubMed/NCBI View Article : Google Scholar

18 

Xu F, Liu F, Zhao H, An G and Feng G: Prognostic significance of mucin antigen MUC1 in various human epithelial cancers: A meta-analysis. Medicine (Baltimore). 94(e2286)2015.PubMed/NCBI View Article : Google Scholar

19 

Baldus SE, Monig SP, Hanisch FG, Zirbes TK, Flucke U, Oelert S, Zilkens G, Madejczik B, Thiele J, Schneider PM, et al: Comparative evaluation of the prognostic value of MUC1, MUC2, sialyl-Lewis(a) and sialyl-Lewis(x) antigens in colorectal adenocarcinoma. Histopathology. 40:440–449. 2002.PubMed/NCBI View Article : Google Scholar

20 

Krishn SR, Kaur S, Sheinin YM, Smith LM, Gautam SK, Patel A, Jain M, Juvvigunta V, Pai P, Lazenby AJ, et al: Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: Clinical implication for improved colon surveillance. Oncotarget. 8:7025–7038. 2016.PubMed/NCBI View Article : Google Scholar

21 

Kim JJ and Khan WL: Goblet cells and mucins: Role in innate defense in enteric infections. Pathogens. 2:55–70. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Szlendak M, Sitarz R, Berbecka M, Mielko J, Morsink F, Maciejewski R, Offerhaus GA and Polkowski WP: Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer. Mol Clin Oncol 13: 52, 2020.
APA
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R. ... Polkowski, W.P. (2020). Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer. Molecular and Clinical Oncology, 13, 52. https://doi.org/10.3892/mco.2020.2122
MLA
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R., Offerhaus, G. A., Polkowski, W. P."Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer". Molecular and Clinical Oncology 13.5 (2020): 52.
Chicago
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R., Offerhaus, G. A., Polkowski, W. P."Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer". Molecular and Clinical Oncology 13, no. 5 (2020): 52. https://doi.org/10.3892/mco.2020.2122
Copy and paste a formatted citation
x
Spandidos Publications style
Szlendak M, Sitarz R, Berbecka M, Mielko J, Morsink F, Maciejewski R, Offerhaus GA and Polkowski WP: Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer. Mol Clin Oncol 13: 52, 2020.
APA
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R. ... Polkowski, W.P. (2020). Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer. Molecular and Clinical Oncology, 13, 52. https://doi.org/10.3892/mco.2020.2122
MLA
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R., Offerhaus, G. A., Polkowski, W. P."Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer". Molecular and Clinical Oncology 13.5 (2020): 52.
Chicago
Szlendak, M., Sitarz, R., Berbecka, M., Mielko, J., Morsink, F., Maciejewski, R., Offerhaus, G. A., Polkowski, W. P."Expression of cyclooxygenase‑2 and mucin 1 in colorectal cancer". Molecular and Clinical Oncology 13, no. 5 (2020): 52. https://doi.org/10.3892/mco.2020.2122
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