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Article

Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer

  • Authors:
    • Katarzyna Jakubowska
    • Mariusz Koda
    • Wojciech Kisielewski
    • Luiza  Kańczuga‑Koda
    • Małgorzata Grudzińska
    • Waldemar Famulski
  • View Affiliations / Copyright

    Affiliations: Department of Pathomorphology, Comprehensive Cancer Center, Medical University of Bialystok, 15‑027 Bialystok, Poland, Department of General Pathomorphology, Medical University of Bialystok, 15‑296 Bialystok, Poland, Department of Medical Pathomorphology, Medical University of Bialystok, 15‑296 Bialystok, Poland
  • Article Number: 56
    |
    Published online on: August 25, 2020
       https://doi.org/10.3892/mco.2020.2126
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Abstract

Colorectal cancer (CRC) is one of the most common malignant cancers worldwide. Patients with CRC are diagnosed based on various predictors, including performance status, clinicopathological factors and TNM classification. The aim of the present study was to analyze the neutrophil and lymphocyte counts, as well as the neutrophil‑to‑lymphocyte ratio (NLR) in pre‑ and postoperative blood samples of patients with CRC in correlation with specific anatomical variables and disease‑ free survival (DFS). The variables pre‑ and postoperative neutrophil count (preNEU and postNEU, respectively), lymphocyte count and NLR were significantly higher in cancer patients than those noted in healthy subjects (all P<0.001). PreNEU count correlated with tumor size, necrosis and tumor budding (R=0.204, P=0.014; R=0.189, P=0.023; R=‑0.174, P=0.036, respectively). Moreover, postNEU was associated only with the histological type (R=0.174; P=0.047). The PreLYMPH count was correlated with distant metastasis (R=‑0.153, P=0.046). PreNLR and postNLR were associated with the expression of various histological markers of disease progression. Analysis of DFS indicated that the postNEU count in the low group exhibited a tendency to lower DFS duration, although the results were not significant (P=0.055). In conclusion, the present study indicated a significant correlation between the factors analyzed in blood samples of CRC patients and the disease progression markers.
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Copy and paste a formatted citation
Spandidos Publications style
Jakubowska K, Koda M, Kisielewski W, Kańczuga‑Koda L, Grudzińska M and Famulski W: Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer. Mol Clin Oncol 13: 56, 2020.
APA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., & Famulski, W. (2020). Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer. Molecular and Clinical Oncology, 13, 56. https://doi.org/10.3892/mco.2020.2126
MLA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., Famulski, W."Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer". Molecular and Clinical Oncology 13.5 (2020): 56.
Chicago
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., Famulski, W."Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer". Molecular and Clinical Oncology 13, no. 5 (2020): 56. https://doi.org/10.3892/mco.2020.2126
Copy and paste a formatted citation
x
Spandidos Publications style
Jakubowska K, Koda M, Kisielewski W, Kańczuga‑Koda L, Grudzińska M and Famulski W: Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer. Mol Clin Oncol 13: 56, 2020.
APA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., & Famulski, W. (2020). Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer. Molecular and Clinical Oncology, 13, 56. https://doi.org/10.3892/mco.2020.2126
MLA
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., Famulski, W."Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer". Molecular and Clinical Oncology 13.5 (2020): 56.
Chicago
Jakubowska, K., Koda, M., Kisielewski, W., Kańczuga‑Koda, L., Grudzińska, M., Famulski, W."Pre‑ and postoperative neutrophil and lymphocyte count and neutrophil‑to‑lymphocyte ratio in patients with colorectal cancer". Molecular and Clinical Oncology 13, no. 5 (2020): 56. https://doi.org/10.3892/mco.2020.2126
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