Malignant mesothelioma metastatic to the oral region and latest topics (Review)

  • Authors:
    • Yuichi Ohnishi
    • Tomoko Fujii
    • Tsukasa Sakamoto
    • Masahiro Watanabe
    • Tomokazu Motohashi
    • Hirohito Kubo
    • Masahiro Nakajima
  • View Affiliations

  • Published online on: September 7, 2020     https://doi.org/10.3892/mco.2020.2131
  • Article Number: 61
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Malignant mesothelioma (MM) is a rare neoplasm with poor prognosis that usually develops after exposure to asbestos, and is characterised by aggressive local invasion and metastatic spread. While metastasis to the oral cavity is very rare, a total of 23 cases of MM metastasising to the oral cavity were identifed. Among those, the tongue was the most common site of metastasis (39.1%), and frequently involved the epithelioid MM cell type. Recent studies have elucidated the mechanisms underlying the development of MM. Chronic inflammation has been implicated in promoting MM growth and was shown to play a key role by driving the release of high mobility group box protein 1 following asbestos deposition. Inherited heterozygous germline mutations in the deubiquitylase BRCA‑associated protein 1 were shown to increase the incidence of MM in some families. Infection by the simian virus 40 was also found to be associated with the occurrence of MM. Moreover, the increasing incidence rates of MM, together with its propensity to metastasise to the oral cavity, indicate that clinicians and pathologists should be highly aware of this disease. Furthermore, identification of novel serum biomarkers would enable better screening and treatment of MM, and improve the survival outcomes.
View References

Related Articles

Journal Cover

November-2020
Volume 13 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ohnishi Y, Fujii T, Sakamoto T, Watanabe M, Motohashi T, Kubo H and Nakajima M: Malignant mesothelioma metastatic to the oral region and latest topics (Review). Mol Clin Oncol 13: 61, 2020
APA
Ohnishi, Y., Fujii, T., Sakamoto, T., Watanabe, M., Motohashi, T., Kubo, H., & Nakajima, M. (2020). Malignant mesothelioma metastatic to the oral region and latest topics (Review). Molecular and Clinical Oncology, 13, 61. https://doi.org/10.3892/mco.2020.2131
MLA
Ohnishi, Y., Fujii, T., Sakamoto, T., Watanabe, M., Motohashi, T., Kubo, H., Nakajima, M."Malignant mesothelioma metastatic to the oral region and latest topics (Review)". Molecular and Clinical Oncology 13.5 (2020): 61.
Chicago
Ohnishi, Y., Fujii, T., Sakamoto, T., Watanabe, M., Motohashi, T., Kubo, H., Nakajima, M."Malignant mesothelioma metastatic to the oral region and latest topics (Review)". Molecular and Clinical Oncology 13, no. 5 (2020): 61. https://doi.org/10.3892/mco.2020.2131