Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
December-2020 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2020 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity

  • Authors:
    • Mario Vicente Giordano
    • Hiram Da Silveira Lucas
    • Rossano   Kepler Alvim Fiorelli
    • Luiz Augusto Giordano
    • Mario   Gáspare Giordano
    • Edmund  Chada Baracat
    • José Maria Soares Júnior
  • View Affiliations / Copyright

    Affiliations: Department of General and Specialized Surgery, Gaffrée e Guinle University Hospital (HUGG), Rio de Janeiro 20270‑004, Brazil, Department of Gynecology and Obstetrics, University of São Paulo (USP), São Paulo 05403‑000, Brazil
  • Article Number: 69
    |
    Published online on: September 17, 2020
       https://doi.org/10.3892/mco.2020.2139
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Obesity is associated with numerous diseases, including endometrial disorders in postmenopausal women, such as adenocarcinoma, hyperplasias and endometrial polyps, and the risk of malignant transformation of these structures. The present study evaluated the influence of body mass index (BMI) on cell proliferation (BCL2 and MKI67) in endometrial polyps in postmenopausal women. A prospective cross‑sectional study using immunohistochemical analysis of the expression of a cell proliferation marker (MKI67) and an anti‑apoptotic gene (BCL2) in endometrial polyps in postmenopausal women was performed. The patients were divided into three groups depending on BMI: i) <24.9 kg/m2 (normal); ii) >25 and <29.9 kg/m2 (overweight); and iii) >30 kg/m2 (obese). The present study analyzed the expression of these markers in relation to polyp size, histological type and time since menopause in 38 patients. The interpretation of MKI67 and BCL2 expression accounted for the percentage of positive cells (scores): 1 (weak), <5% of cells showed expression; 2 (moderate), between 5 and 50%; and 3 (intense), >50%. Statistical analysis was performed using GraphPad InStat version 3.00 software. ANOVA was used to analyze BCL2 and MKI67 expression. A significance level of P<0.05 was adopted for rejecting the null hypothesis. There was greater glandular expression of MKI67 in obese women than in normal weight women (P=0.02) and greater expression of BCL2 in the stroma of polyps >2 cm (P=0.03). Hyperplastic polyps exhibited hyperexpression of MKI67 (P=0.04) compared with atrophic polyps. No difference in MKI67 and BCL2 expression was identified in the glands and stroma of polyps when comparing overweight and obese postmenopausal patients. The present findings suggest that BMI has an influence on proliferation markers (MKI67) in the polyps of postmenopausal women and that polyps >2 cm exhibit hyperexpression of BCL2 in the stroma.
View Figures

Figure 1

View References

1 

World Health Organization (WHO): Obesity and overweight. WHO, Geneva, 2019. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed November 20, 2019.

2 

Onalan R, Onalan G, Tonguc E, Ozdener T, Dogan M and Mollamahmutoglu L: Body mass index is na independente risk factor for the development of endometrial polyps in patients unfergoing in vitro fertilization. Fertil Steril. 91:1056–1060. 2009.PubMed/NCBI View Article : Google Scholar

3 

Costa-Paiva I, Godoy CE Jr, Antunes A Jr, Caseiro JD, Arthuso M and Pinto-Neto AM: Risk of malignancy in endometrial polyps in premenopausal and postmenopausal women according to clinicopathologic characteristics. Menopause. 18:1278–1282. 2011.PubMed/NCBI View Article : Google Scholar

4 

Dreisler E, Stampe SS, Ibsen PH and Lose G: Prevalence of endometria polyps and abnormal uterine bleeding in a Danish population aged 20-74 years. Ultrasound Obstet Gynecol. 33:102–108. 2009.PubMed/NCBI View Article : Google Scholar

5 

Pinheiro A, Antunes Jr A, Andrade L, Brot L, Pinto-Neto AM and Costa-Paiva L: Expression of hormone receptors, BCL2, Cox-2 and MKI67 in benign endometrial polyps and their association with obesity. Mol Med Rep. 9:2335–2341. 2014.PubMed/NCBI View Article : Google Scholar

6 

Taylor LJ, Jackson TL, Reid JG and Duffy SRG: The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. BJOG. 110:794–798. 2003.PubMed/NCBI

7 

Amezcua CA, Zheng W, Muderspach LI and Felix JC: Down-regulation of BCL2 is a potential marker of the efficacy of progestin therapy in the treatment of endometrial hyperplasia. Gynecol Oncol. 73:126–136. 1999.PubMed/NCBI View Article : Google Scholar

8 

Nogueira AA: Pólipos endometriais. Rev Bras Ginecol Obstet. 27:289–292. 2005.

9 

Vinatier D, Dufour P and Subtil D: Apoptosis: A programmed cell death involved in ovarian and uterine physiology. Eur J Obstet Gynecol Reprod Biol. 67:85–102. 1996.PubMed/NCBI View Article : Google Scholar

10 

Inceboz US, Nese N, Uyar Y, Ozcakir HT, Kurtul O, Baytur YB, Kandiloglu AR, Caglar H and Fraser IS: Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps. Gynecol Obstet Invest. 61:24–28. 2006.PubMed/NCBI View Article : Google Scholar

11 

Arends MJ: Apoptosis in the endometrium. Histopathology. 35:174–178. 1999.PubMed/NCBI View Article : Google Scholar

12 

Gompel A, Sabourin JC, Martin A, Yaneva H, Audouin J, Decroix Y and Poitout P: BCL2 expression in normal endometrium during the menstrual cycle. Am J Pathol. 144:1195–1202. 1994.PubMed/NCBI

13 

Mittal K, Schwartz I, Goswami S and Demopoulos R: Estrogen and progesterone receptors in the endometrial polyps. Int J Gynecol Pathol. 15:345–348. 1996.PubMed/NCBI View Article : Google Scholar

14 

Gul A, Ugur M, Iskender C, Zulfikaroglu E and Ozaksit G: Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and its relationship to clinical parameters. Arch Gynecol Obstet. 281:479–483. 2010.PubMed/NCBI View Article : Google Scholar

15 

Belisario MSN, Vassallo J, Andrade LALA, Alvarenga M, Pinto GA and Monteiro IMU: The expression of the hormone receptors in the endometrium and endometrial polyps in postmenopausal women and its relationship to body mass index. Maturitas. 53:114–118. 2006.PubMed/NCBI View Article : Google Scholar

16 

Siiteri PK and Mac Donald PC: Role of extraglandular estrogen in human endocrinology. In: Handbook of Physiology. Geyer SR, Astwood EB and Greep RD (eds); Endocrinology, American Physiology Society, Washington DC, pp615, 1973.

17 

Oguz S, Sargin A, Kelekci S, Aytan H, Tapisiz OL and Mollamahmutoglu L: The role of hormone replacement therapy in endometrial polyps formation. Maturitas. 50:231–236. 2005.PubMed/NCBI View Article : Google Scholar

18 

Villavicencio A, Aguilar G, Argüello G, Dünner C, Gabler F, Soto E, Gaete F, Peñaloza P, Celis M and Rojas C: The effect of overweight and obesity on proliferation and activation of AKT and ERK in human endometria. Gynecol Oncol. 117:96–102. 2010.PubMed/NCBI View Article : Google Scholar

19 

Stănescu AD, Nistor I, Potecã AG, Ditescu D and Comãnescu M: Prognostic biomarkers in endometrial adenocarcinoma. Rom J Morphol Embryol. 55:1339–1344. 2014.PubMed/NCBI

20 

Troncon JK, Meola J, Candido-Dos-Reis FJ, Poli-Neto OB, Nogueira AA and Rosa-E-Silva JC: Analysis of differential genetic expression in endometrial polyps of postmenopausal women. Climacteric. 20:462–466. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Giordano MV, Lucas HD, Fiorelli RK, Giordano LA, Giordano MG, Baracat EC and Júnior JM: Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity. Mol Clin Oncol 13: 69, 2020.
APA
Giordano, M.V., Lucas, H.D., Fiorelli, R.K., Giordano, L.A., Giordano, M.G., Baracat, E.C., & Júnior, J.M. (2020). Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity. Molecular and Clinical Oncology, 13, 69. https://doi.org/10.3892/mco.2020.2139
MLA
Giordano, M. V., Lucas, H. D., Fiorelli, R. K., Giordano, L. A., Giordano, M. G., Baracat, E. C., Júnior, J. M."Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity". Molecular and Clinical Oncology 13.6 (2020): 69.
Chicago
Giordano, M. V., Lucas, H. D., Fiorelli, R. K., Giordano, L. A., Giordano, M. G., Baracat, E. C., Júnior, J. M."Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity". Molecular and Clinical Oncology 13, no. 6 (2020): 69. https://doi.org/10.3892/mco.2020.2139
Copy and paste a formatted citation
x
Spandidos Publications style
Giordano MV, Lucas HD, Fiorelli RK, Giordano LA, Giordano MG, Baracat EC and Júnior JM: Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity. Mol Clin Oncol 13: 69, 2020.
APA
Giordano, M.V., Lucas, H.D., Fiorelli, R.K., Giordano, L.A., Giordano, M.G., Baracat, E.C., & Júnior, J.M. (2020). Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity. Molecular and Clinical Oncology, 13, 69. https://doi.org/10.3892/mco.2020.2139
MLA
Giordano, M. V., Lucas, H. D., Fiorelli, R. K., Giordano, L. A., Giordano, M. G., Baracat, E. C., Júnior, J. M."Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity". Molecular and Clinical Oncology 13.6 (2020): 69.
Chicago
Giordano, M. V., Lucas, H. D., Fiorelli, R. K., Giordano, L. A., Giordano, M. G., Baracat, E. C., Júnior, J. M."Expression levels of BCL2 and MKI67 in endometrial polyps in postmenopausal women and their correlation with obesity". Molecular and Clinical Oncology 13, no. 6 (2020): 69. https://doi.org/10.3892/mco.2020.2139
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team