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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2020 Volume 13 Issue 6

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Review

Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)

  • Authors:
    • Ganggang Jiang
    • Zhengming Su
    • Xue Liang
    • Yiqiao Huang
    • Ziquan Lan
    • Xianhan Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China, Department of Center Laboratory, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China
  • Article Number: 76
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    Published online on: September 24, 2020
       https://doi.org/10.3892/mco.2020.2146
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Abstract

Prostate cancer (PCa) is one of the most frequently diagnosed malignancy. Although there have been many advances in PCa diagnosis and therapy, the concrete mechanism remains unknown. Long non‑coding RNAs (lncRNAs) are novel biomarkers associated with PCa, and their dysregulated expression is closely associated with risk stratification, diagnosis and carcinogenesis. Accumulating evidence has suggested that lncRNAs play important roles in prostate tumorigenesis through relevant pathways, such as androgen receptor interaction and PI3K/Akt. The present review systematically summarized the potential clinical utility of lncRNAs and provided a novel guide for their function in PCa.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014.PubMed/NCBI View Article : Google Scholar

2 

Carter HB and Pearson JD: PSA velocity for the diagnosis of early prostate cancer. A new concept. Urol Clin North Am. 20:665–670. 1993.PubMed/NCBI

3 

Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M, Salvioni R, Supino R, Moretti R, Limonta P, et al: miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res. 69:2287–2295. 2009.PubMed/NCBI View Article : Google Scholar

4 

Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, Muller PA, Dotsch V, Kehrloesser S, Sayan BS, et al: Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci USA. 109:15312–15317. 2012.PubMed/NCBI View Article : Google Scholar

5 

Gandellini P, Profumo V, Casamichele A, Fenderico N, Borrelli S, Petrovich G, Santilli G, Callari M, Colecchia M, Pozzi S, et al: miR-205 regulates basement membrane deposition in human prostate: Implications for cancer development. Cell Death Differ. 19:1750–1760. 2012.PubMed/NCBI View Article : Google Scholar

6 

Bonci D, Coppola V, Musumeci M, Addario A, Giuffrida R, Memeo L, D'Urso L, Pagliuca A, Biffoni M, Labbaye C, et al: The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med. 14:1271–1277. 2008.PubMed/NCBI View Article : Google Scholar

7 

Park TY, Chae JY, Kim JW, Kim JW, Oh MM, Yoon CY and Moon du G: Prostate-specific antigen mass and free prostate-specific antigen mass for predicting the prostate volume of korean men with biopsy-proven benign prostatic hyperplasia. Korean J Urol. 54:609–614. 2013.PubMed/NCBI View Article : Google Scholar

8 

Wang Y, Hu HL, Liu ZF, Sun WZ, Chen XX and Wu CL: Diagnosis and treatment of xanthogranulomatous prostatitis: A case report and review of the literature. Zhonghua Nan Ke Xue. 19:149–152. 2013.PubMed/NCBI(In Chinese).

9 

ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. 489:57–74. 2012.PubMed/NCBI View Article : Google Scholar

10 

Ma W, Ay F, Lee C, Gulsoy G, Deng X, Cook S, Hesson J, Cavanaugh C, Ware CB, Krumm A, et al: Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes. Nat Methods. 12:71–78. 2015.PubMed/NCBI View Article : Google Scholar

11 

Ling H, Vincent K, Pichler M, Fodde R, Berindan-Neagoe I, Slack FJ and Calin GA: Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 34:5003–5011. 2015.PubMed/NCBI View Article : Google Scholar

12 

Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermuller J, Hofacker IL, et al: RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science. 316:1484–1488. 2007.PubMed/NCBI View Article : Google Scholar

13 

Brosnan CA and Voinnet O: The long and the short of noncoding RNAs. Curr Opin Cell Biol. 21:416–425. 2009.PubMed/NCBI View Article : Google Scholar

14 

Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10(38)2011.PubMed/NCBI View Article : Google Scholar

15 

Mercer TR and Mattick JS: Structure and function of long noncoding RNAs in epigenetic regulation. Nat Struct Mol Biol. 20:300–307. 2013.PubMed/NCBI View Article : Google Scholar

16 

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, et al: The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 22:1775–1789. 2012.PubMed/NCBI View Article : Google Scholar

17 

Kino T, Hurt DE, Ichijo T, Nader N and Chrousos GP: Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal. 3(ra8)2010.PubMed/NCBI View Article : Google Scholar

18 

Mallory AC and Shkumatava A: lncRNAs in vertebrates: Advances and challenges. Biochimie. 117:3–14. 2015.PubMed/NCBI View Article : Google Scholar

19 

Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, et al: A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol. 6:308–318. 2004.PubMed/NCBI View Article : Google Scholar

20 

Seles M, Hutterer GC, Kiesslich T, Pummer K, Berindan-Neagoe I, Perakis S, Schwarzenbacher D, Stotz M, Gerger A and Pichler M: Current insights into long non-coding RNAs in renal cell carcinoma. Int J Mol Sci. 17(573)2016.PubMed/NCBI View Article : Google Scholar

21 

Smolle M, Uranitsch S, Gerger A, Pichler M and Haybaeck J: Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer. Int J Mol Sci. 15:13993–14013. 2014.PubMed/NCBI View Article : Google Scholar

22 

Smolle MA, Bullock MD, Ling H, Pichler M and Haybaeck J: Long non-coding RNAs in endometrial carcinoma. Int J Mol Sci. 16:26463–26472. 2015.PubMed/NCBI View Article : Google Scholar

23 

Bezan A, Gerger A and Pichler M: MicroRNAs in testicular cancer: Implications for pathogenesis, diagnosis, prognosis and therapy. Anticancer Res. 34:2709–2713. 2014.PubMed/NCBI

24 

Ling H, Krassnig L, Bullock MD and Pichler M: MicroRNAs in testicular cancer diagnosis and prognosis. Urol Clin North Am. 43:127–134. 2016.PubMed/NCBI View Article : Google Scholar

25 

Cerk S, Schwarzenbacher D, Adiprasito JB, Stotz M, Hutterer GC, Gerger A, Ling H, Calin GA and Pichler M: Current status of long Non-coding RNAs in human breast cancer. Int J Mol Sci. 17(1485)2016.PubMed/NCBI View Article : Google Scholar

26 

Zebisch A, Hatzl S, Pichler M, Wolfler A and Sill H: Therapeutic resistance in acute myeloid leukemia: The role of non-coding RNAs. Int J Mol Sci. 17(2080)2016.PubMed/NCBI View Article : Google Scholar

27 

Troppan K, Wenzl K, Deutsch A, Ling H, Neumeister P and Pichler M: MicroRNAs in diffuse large B-cell lymphoma: Implications for pathogenesis, diagnosis, prognosis and therapy. Anticancer Res. 34:557–564. 2014.PubMed/NCBI

28 

Bussemakers MJ, van Bokhoven A, Verhaegh GW, Smit FP, Karthaus HF, Schalken JA, Debruyne FM, Ru N and Isaacs WB: DD3: A new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res. 59:5975–5979. 1999.PubMed/NCBI

29 

Gelmann EP: Molecular biology of the androgen receptor. J Clin Oncol. 20:3001–3015. 2002.PubMed/NCBI View Article : Google Scholar

30 

Claessens F, Denayer S, Van Tilborgh N, Kerkhofs S, Helsen C and Haelens A: Diverse roles of androgen receptor (AR) domains in AR-mediated signaling. Nucl Recept Signal. 6(e008)2008.PubMed/NCBI View Article : Google Scholar

31 

Heemers HV and Tindall DJ: Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev. 28:778–808. 2007.PubMed/NCBI View Article : Google Scholar

32 

Chang CS, Kokontis J and Liao ST: Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 240:324–326. 1988.PubMed/NCBI View Article : Google Scholar

33 

Heinlein CA and Chang C: Androgen receptor in prostate cancer. Endocr Rev. 25:276–308. 2004.PubMed/NCBI View Article : Google Scholar

34 

Jentzmik F, Azoitei A, Zengerling F, Damjanoski I and Cronauer MV: Androgen receptor aberrations in the era of abiraterone and enzalutamide. World J Urol. 34:297–303. 2016.PubMed/NCBI View Article : Google Scholar

35 

Mitsiades N: A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer. Cancer Res. 73:4599–4605. 2013.PubMed/NCBI View Article : Google Scholar

36 

Scher HI and Sawyers CL: Biology of progressive, castration-resistant prostate cancer: Directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol. 23:8253–8261. 2005.PubMed/NCBI View Article : Google Scholar

37 

Karantanos T, Corn PG and Thompson TC: Prostate cancer progression after androgen deprivation therapy: Mechanisms of castrate resistance and novel therapeutic approaches. Oncogene. 32:5501–5511. 2013.PubMed/NCBI View Article : Google Scholar

38 

Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, et al: lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature. 500:598–602. 2013.PubMed/NCBI View Article : Google Scholar

39 

Srikantan V, Zou Z, Petrovics G, Xu L, Augustus M, Davis L, Livezey JR, Connell T, Sesterhenn IA, Yoshino K, et al: PCGEM1, a prostate-specific gene, is overexpressed in prostate cancer. Proc Natl Acad Sci USA. 97:12216–12221. 2000.PubMed/NCBI View Article : Google Scholar

40 

Parolia A, Crea F, Xue H, Wang Y, Mo F, Ramnarine VR, Liu HH, Lin D, Saidy NR, Clermont PL, et al: The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo. Mol Cancer. 14(46)2015.PubMed/NCBI View Article : Google Scholar

41 

Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, Humphreys E, Han M, Partin AW, Vessella RL, Isaacs WB, et al: Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res. 69:16–22. 2009.PubMed/NCBI View Article : Google Scholar

42 

Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C, Edwards J, Isaacs WB, Nelson PS, Bluemn E, et al: Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res. 72:3457–3462. 2012.PubMed/NCBI View Article : Google Scholar

43 

Khurana N, Kim H, Chandra PK, Talwar S, Sharma P, Abdel-Mageed AB, Sikka SC and Mondal D: Multimodal actions of the phytochemical sulforaphane suppress both AR and AR-V7 in 22Rv1 cells: Advocating a potent pharmaceutical combination against castration-resistant prostate cancer. Oncol Rep. 38:2774–2786. 2017.PubMed/NCBI View Article : Google Scholar

44 

Zhang Z, Zhou N, Huang J, Ho TT, Zhu Z, Qiu Z, Zhou X, Bai C, Wu F, Xu M and Mo YY: Regulation of androgen receptor splice variant AR3 by PCGEM1. Oncotarget. 7:15481–15491. 2016.PubMed/NCBI View Article : Google Scholar

45 

Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, et al: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 464:1071–1076. 2010.PubMed/NCBI View Article : Google Scholar

46 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011.PubMed/NCBI View Article : Google Scholar

47 

Nakagawa T, Endo H, Yokoyama M, Abe J, Tamai K, Tanaka N, Sato I, Takahashi S, Kondo T and Satoh K: Large noncoding RNA HOTAIR enhances aggressive biological behavior and is associated with short disease-free survival in human non-small cell lung cancer. Biochem Biophys Res Commun. 436:319–324. 2013.PubMed/NCBI View Article : Google Scholar

48 

Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S and Safe S: HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32:1616–1625. 2013.PubMed/NCBI View Article : Google Scholar

49 

Zhang A, Zhao JC, Kim J, Fong KW, Yang YA, Chakravarti D, Mo YY and Yu J: lncRNA HOTAIR Enhances the Androgen-receptor-mediated transcriptional program and drives castration-resistant prostate cancer. Cell Rep. 13:209–221. 2015.PubMed/NCBI View Article : Google Scholar

50 

Takayama K, Tsutsumi S, Katayama S, Okayama T, Horie-Inoue K, Ikeda K, Urano T, Kawazu C, Hasegawa A, Ikeo K, et al: Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells. Oncogene. 30:619–630. 2011.PubMed/NCBI View Article : Google Scholar

51 

Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, Urano T, Fujimura T, Takagi K, Takahashi S, et al: Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J. 32:1665–1680. 2013.PubMed/NCBI View Article : Google Scholar

52 

Clarke RA, Zhao Z, Guo AY, Roper K, Teng L, Fang ZM, Samaratunga H, Lavin MF and Gardiner RA: New genomic structure for prostate cancer specific gene PCA3 within BMCC1: Implications for prostate cancer detection and progression. PLoS One. 4(e4995)2009.PubMed/NCBI View Article : Google Scholar

53 

de Kok JB, Verhaegh GW, Roelofs RW, Hessels D, Kiemeney LA, Aalders TW, Swinkels DW and Schalken JA: DD3(PCA3), a very sensitive and specific marker to detect prostate tumors. Cancer Res. 62:2695–2698. 2002.PubMed/NCBI

54 

van Bokhoven A, Varella-Garcia M, Korch C, Johannes WU, Smith EE, Miller HL, Nordeen SK, Miller GJ and Lucia MS: Molecular characterization of human prostate carcinoma cell lines. Prostate. 57:205–225. 2003.PubMed/NCBI View Article : Google Scholar

55 

Yang Z, Yu L and Wang Z: PCA3 and TMPRSS2-ERG gene fusions as diagnostic biomarkers for prostate cancer. Chin J Cancer Res. 28:65–71. 2016.PubMed/NCBI View Article : Google Scholar

56 

Lemos AE, Ferreira LB, Batoreu NM, de Freitas PP, Bonamino MH and Gimba ER: PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells. Tumour Biol. 37:11339–11348. 2016.PubMed/NCBI View Article : Google Scholar

57 

Sung YY and Cheung E: Androgen receptor co-regulatory networks in castration-resistant prostate cancer. Endocr Relat Cancer. 21:R1–R11. 2013.PubMed/NCBI View Article : Google Scholar

58 

Lui GY, Kovacevic Z, Richardson V, Merlot AM, Kalinowski DS and Richardson DR: Targeting cancer by binding iron: Dissecting cellular signaling pathways. Oncotarget. 6:18748–18779. 2015.PubMed/NCBI View Article : Google Scholar

59 

Chen H, Zhou L, Wu X, Li R, Wen J, Sha J and Wen X: The PI3K/AKT pathway in the pathogenesis of prostate cancer. Front Biosci (Landmark Ed). 21:1084–1091. 2016.PubMed/NCBI View Article : Google Scholar

60 

Morgan TM, Koreckij TD and Corey E: Targeted therapy for advanced prostate cancer: Inhibition of the PI3K/Akt/mTOR pathway. Curr Cancer Drug Targets. 9:237–249. 2009.PubMed/NCBI View Article : Google Scholar

61 

Gao N, Zhang Z, Jiang BH and Shi X: Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 310:1124–1132. 2003.PubMed/NCBI View Article : Google Scholar

62 

Kim SM, Park JH, Kim KD, Nam D, Shim BS, Kim SH and Ahn KS, Choi SH and Ahn KS: Brassinin induces apoptosis in PC-3 human prostate cancer cells through the suppression of PI3K/Akt/mTOR/S6K1 signaling cascades. Phytother Res. 28:423–431. 2014.PubMed/NCBI View Article : Google Scholar

63 

Vo BT, Morton D Jr, Komaragiri S, Millena AC, Leath C and Khan SA: TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway. Endocrinology. 154:1768–1779. 2013.PubMed/NCBI View Article : Google Scholar

64 

Yuan JH, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014.PubMed/NCBI View Article : Google Scholar

65 

Xu S, Yi XM, Tang CP, Ge JP, Zhang ZY and Zhou WQ: Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. Oncol Rep. 36:10–22. 2016.PubMed/NCBI View Article : Google Scholar

66 

Xue M, Chen W and Li X: Urothelial cancer associated 1: A long noncoding RNA with a crucial role in cancer. J Cancer Res Clin Oncol. 142:1407–1419. 2016.PubMed/NCBI View Article : Google Scholar

67 

Ghiam AF, Taeb S, Huang X, Huang V, Ray J, Scarcello S, Hoey C, Jahangiri S, Fokas E, Loblaw A, et al: Long non-coding RNA urothelial carcinoma associated 1 (UCA1) mediates radiation response in prostate cancer. Oncotarget. 8:4668–4689. 2017.PubMed/NCBI View Article : Google Scholar

68 

Wu J, Cheng G, Zhang C, Zheng Y, Xu H, Yang H and Hua L: Long noncoding RNA LINC01296 is associated with poor prognosis in prostate cancer and promotes cancer-cell proliferation and metastasis. Onco Targets Ther. 10:1843–1852. 2017.PubMed/NCBI View Article : Google Scholar

69 

Wang J, Cheng G, Li X, Pan Y, Qin C, Yang H, Hua L and Wang Z: Overexpression of long non-coding RNA LOC400891 promotes tumor progression and poor prognosis in prostate cancer. Tumour Biol. 37:9603–9613. 2016.PubMed/NCBI View Article : Google Scholar

70 

Thorne H, Mitchell G and Fox S: kConFab: A familial breast cancer consortium facilitating research and translational oncology. J Natl Cancer Inst Monogr. 2011:79–81. 2011.PubMed/NCBI View Article : Google Scholar

71 

Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y and Liu XS: Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 20:908–913. 2013.PubMed/NCBI View Article : Google Scholar

72 

Prensner JR, Chen W, Han S, Iyer MK, Cao Q, Kothari V, Evans JR, Knudsen KE, Paulsen MT, Ljungman M, et al: The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc. Neoplasia. 16:900–908. 2014.PubMed/NCBI View Article : Google Scholar

73 

Prensner JR, Zhao S, Erho N, Schipper M, Iyer MK, Dhanasekaran SM, Magi-Galluzzi C, Mehra R, Sahu A, Siddiqui J, et al: RNA biomarkers associated with metastatic progression in prostate cancer: A multi-institutional high-throughput analysis of SChLAP1. Lancet Oncol. 15:1469–1480. 2014.PubMed/NCBI View Article : Google Scholar

74 

Mehra R, Udager AM, Ahearn TU, Cao X, Feng FY, Loda M, Petimar JS, Kantoff P, Mucci LA and Chinnaiyan AM: Overexpression of the long Non-coding RNA SChLAP1 independently predicts lethal prostate cancer. Eur Urol. 70:549–552. 2016.PubMed/NCBI View Article : Google Scholar

75 

Mehra R, Shi Y, Udager AM, Prensner JR, Sahu A, Iyer MK, Siddiqui J, Cao X, Wei J, Jiang H, et al: A novel RNA in situ hybridization assay for the long noncoding RNA SChLAP1 predicts poor clinical outcome after radical prostatectomy in clinically localized prostate cancer. Neoplasia. 16:1121–1127. 2014.PubMed/NCBI View Article : Google Scholar

76 

Prensner JR, Iyer MK, Sahu A, Asangani IA, Cao Q, Patel L, Vergara IA, Davicioni E, Erho N, Ghadessi M, et al: The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet. 45:1392–1398. 2013.PubMed/NCBI View Article : Google Scholar

77 

Ren S, Liu Y, Xu W, Sun Y, Lu J, Wang F, Wei M, Shen J, Hou J, Gao X, et al: Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. J Urol. 190:2278–2287. 2013.PubMed/NCBI View Article : Google Scholar

78 

Viazzi F, Bonino B, Ratto E, Desideri G and Pontremoli R: Hyperuricemia, diabetes and hypertension. G Ital Nefrol. 32 (Suppl 62)(gin/32.S62.10)2015.PubMed/NCBI(In Italian).

79 

Mei YH, Yu JP and Li G: An extramedullary plasmacytoma in the kidney of a 14-year-old girl: Case report and review of the literature. Medicine (Baltimore). 96(e6092)2017.PubMed/NCBI View Article : Google Scholar

80 

Zhao Z, Chen C, Liu Y and Wu C: 17β-Estradiol treatment inhibits breast cell proliferation, migration and invasion by decreasing MALAT-1 RNA level. Biochem Biophys Res Commun. 445:388–393. 2014.PubMed/NCBI View Article : Google Scholar

81 

Ying L, Chen Q, Wang Y, Zhou Z, Huang Y and Qiu F: Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst. 8:2289–2294. 2012.PubMed/NCBI View Article : Google Scholar

82 

Hu L, Wu Y, Tan D, Meng H, Wang K, Bai Y and Yang K: Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma. J Exp Clin Cancer Res. 34(7)2015.PubMed/NCBI View Article : Google Scholar

83 

Wang X, Li M, Wang Z, Han S, Tang X, Ge Y, Zhou L, Zhou C, Yuan Q and Yang M: Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells. J Biol Chem. 290:3925–3935. 2015.PubMed/NCBI View Article : Google Scholar

84 

Hirata H, Hinoda Y, Shahryari V, Deng G, Nakajima K, Tabatabai ZL, Ishii N and Dahiya R: Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205. Cancer Res. 75:1322–1331. 2015.PubMed/NCBI View Article : Google Scholar

85 

Joaquin M and Watson RJ: Cell cycle regulation by the B-Myb transcription factor. Cell Mol Life Sci. 60:2389–2401. 2003.PubMed/NCBI View Article : Google Scholar

86 

Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J and Yu J: lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J. 281:3766–3775. 2014.PubMed/NCBI View Article : Google Scholar

87 

Prensner JR, Chen W, Iyer MK, Cao Q, Ma T, Han S, Sahu A, Malik R, Wilder-Romans K, Navone N, et al: PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 74:1651–1660. 2014.PubMed/NCBI View Article : Google Scholar

88 

Gazy I, Zeevi DA, Renbaum P, Zeligson S, Eini L, Bashari D, Smith Y, Lahad A, Goldberg M, Ginsberg D and Levy-Lahad E: TODRA, a lncRNA at the RAD51 locus, is oppositely regulated to RAD51, and enhances RAD51-dependent DSB (Double Strand Break) repair. PLoS One. 10(e0134120)2015.PubMed/NCBI View Article : Google Scholar

89 

Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014.PubMed/NCBI View Article : Google Scholar

90 

Jalali S, Bhartiya D, Lalwani MK, Sivasubbu S and Scaria V: Systematic transcriptome wide analysis of lncRNA-miRNA interactions. PLoS One. 8(e53823)2013.PubMed/NCBI View Article : Google Scholar

91 

Chiyomaru T, Yamamura S, Fukuhara S, Yoshino H, Kinoshita T, Majid S, Saini S, Chang I, Tanaka Y, Enokida H, et al: Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR. PLoS One. 8(e70372)2013.PubMed/NCBI View Article : Google Scholar

92 

Salehi S, Taheri MN, Azarpira N, Zare A and Behzad-Behbahani A: State of the art technologies to explore long non-coding RNAs in cancer. J Cell Mol Med. 21:3120–3140. 2017.PubMed/NCBI View Article : Google Scholar

93 

Tsai MC, Spitale RC and Chang HY: Long intergenic noncoding RNAs: New links in cancer progression. Cancer Res. 71:3–7. 2011.PubMed/NCBI View Article : Google Scholar

94 

Shechner DM, Hacisuleyman E, Younger ST and Rinn JL: Multiplexable, locus-specific targeting of long RNAs with CRISPR-display. Nat Methods. 12:664–670. 2015.PubMed/NCBI View Article : Google Scholar

95 

St Laurent G, Wahlestedt C and Kapranov P: The Landscape of long noncoding RNA classification. Trends Genet. 31:239–251. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jiang G, Su Z, Liang X, Huang Y, Lan Z and Jiang X: Long non‑coding RNAs in prostate tumorigenesis and therapy (Review). Mol Clin Oncol 13: 76, 2020.
APA
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., & Jiang, X. (2020). Long non‑coding RNAs in prostate tumorigenesis and therapy (Review). Molecular and Clinical Oncology, 13, 76. https://doi.org/10.3892/mco.2020.2146
MLA
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., Jiang, X."Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)". Molecular and Clinical Oncology 13.6 (2020): 76.
Chicago
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., Jiang, X."Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)". Molecular and Clinical Oncology 13, no. 6 (2020): 76. https://doi.org/10.3892/mco.2020.2146
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang G, Su Z, Liang X, Huang Y, Lan Z and Jiang X: Long non‑coding RNAs in prostate tumorigenesis and therapy (Review). Mol Clin Oncol 13: 76, 2020.
APA
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., & Jiang, X. (2020). Long non‑coding RNAs in prostate tumorigenesis and therapy (Review). Molecular and Clinical Oncology, 13, 76. https://doi.org/10.3892/mco.2020.2146
MLA
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., Jiang, X."Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)". Molecular and Clinical Oncology 13.6 (2020): 76.
Chicago
Jiang, G., Su, Z., Liang, X., Huang, Y., Lan, Z., Jiang, X."Long non‑coding RNAs in prostate tumorigenesis and therapy (Review)". Molecular and Clinical Oncology 13, no. 6 (2020): 76. https://doi.org/10.3892/mco.2020.2146
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