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Article

Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors

  • Authors:
    • Toshiki Yajima
    • Akira Mogi
    • Ei Yamaki
    • Ryouichi Onozato
    • Takayuki  Kosaka
    • Ken Shirabe
    • Hiroyuki Kuwano
  • View Affiliations / Copyright

    Affiliations: Department of General Surgical Science, Gunma University Graduate School of Medicine, Maebashi‑shi, Gunma 371‑8511, Japan
  • Article Number: 85
    |
    Published online on: October 16, 2020
       https://doi.org/10.3892/mco.2020.2155
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Abstract

The present study retrospectively examined the diagnostic utility of adding positron emission tomography (PET) or magnetic resonance imaging (MRI) to computed tomography (CT) alone for preoperative diagnosis of anterior mediastinal tumors. A total of 104 consecutive patients who had undergone surgical resection of anterior mediastinal tumors were divided into two groups: Additional PET to another modality and no additional PET to another modality, and further subdivided into three groups: CT alone, additional MRI to CT and additional PET to CT. The sensitivity, specificity, and accuracy for diagnosing malignant tumors in each subgroup was calculated. Comparing the two groups, the diagnostic sensitivity was similar for additional PET (98.0%) and no additional PET (95.2%) groups; however, the specificity and accuracy for additional PET (75.0 and 92.2%, respectively) were significantly improved compared with no additional PET (31.6 and 65.0%, respectively). In the subgroup analysis, adding PET to CT showed an improvement in specificity and positive predictive value for detecting malignant tumors, compared with either additional MRI to CT or CT alone. Additional PET, but not MRI, has advantages over CT alone in clinically distinguishing benign from malignant tumors of the mediastinum.
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1 

Duwe BV, Sterman DH and Musani AI: Tumors of the mediastinum. Chest. 128:2893–2909. 2005.PubMed/NCBI View Article : Google Scholar

2 

Yoneda KY, Louie S and Shelton DK: Mediastinal tumors. Curr Opin Pulm Med. 7:226–233. 2001.

3 

Kern JA, Deniel TN, Trible CG, Silen ML and Rodgers BM: Thoracoscopic diagnosis and treatment of mediastinal masses. Ann Thorac Surg. 56:92–96. 1993.PubMed/NCBI View Article : Google Scholar

4 

Rendina EA, Venuta F, De Giacomo T, Ciriaco PP, Pescarmona EO, Francioni F, Pulsoni A, Malagnino F and Ricci C: Comparative merits of thoracoscopy, mediastinoscopy, and mediastinotomy for mediastinal biopsy. Ann Thorac Surg. 57:992–995. 1994.PubMed/NCBI View Article : Google Scholar

5 

David SE, Gregory JR and Wallace A: NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Thymomas and Thymic Carcinomas. J Natl Compr Cancer Netw. 11:562–576. 2013.

6 

Tomiyama N, Honda O, Tsubamoto M, Inoue A, Sumikawa H, Kuriyama K, Kusumoto M, Johkoh T and Nakamura H: Anterior mediastinal tumors: Diagnostic accuracy of CT and MRI. Eur J Radiol. 69:280–288. 2009.PubMed/NCBI View Article : Google Scholar

7 

Sakai S, Murayama S, Soeda H, Matsuo Y, Ono M and Masuda K: Differential diagnosis between thymoma and non-thymoma by dynamic MR imaging. Acta Radiol. 43:262–268. 2002.PubMed/NCBI View Article : Google Scholar

8 

Endo M, Nakagawa K, Ohde Y, Okumura T, Kondo H, Igawa S, Nakamura Y, Tsuya A, Murakami H, Takahashi T, et al: Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors. Lung Cancer. 61:350–355. 2008.PubMed/NCBI View Article : Google Scholar

9 

Terzi A, Bertolaccini L, Rizzardi G, Luzzi L, Bianchi A, Campione A, Comino A and Biggi A: Usefulness of 18-F FDG PET/CT in the pre-treatment evaluation of thymic epithelial neoplasms. Lung Cancer. 74:239–243. 2011.PubMed/NCBI View Article : Google Scholar

10 

Lococo F, Cesario A, Okami J, Cardillo G, Cavuto S, Tokunaga T, Apolone G, Margaritora S and Granone P: Role of combined18F-FDG-PET/CT for predicting the WHO malignancy grade of thymic epithelial tumors: A multicenter analysis. Lung Cancer. 82:245–251. 2013.PubMed/NCBI View Article : Google Scholar

11 

Igai H, Matsuura N, Tarumi S, Chang SS, Misaki N, Go T, Ishikawa S and Yokomise H: Usefulness of [18F]fluoro-2-deoxy-D-glucose positron emission tomography for predicting the world health organization malignancy grade of thymic epithelial tumors. Eur J Cardiothorac Surg. 40:143–145. 2011.PubMed/NCBI View Article : Google Scholar

12 

Otsuka H: The utility of FDG-PET in the diagnosis of thymic epithelial tumors. J Med Invest. 59:225–234. 2012.PubMed/NCBI View Article : Google Scholar

13 

Luzzi L, Campione A, Gorla A, Vassallo G, Bianchi A, Biggi A and Terzi A: Role of fluorine-flurodeoxyglucose positron emission tomography/computed tomography in preoperative assessment of anterior mediastinal masses. Eur J Cardiothorac Surg. 36:475–479. 2009.PubMed/NCBI View Article : Google Scholar

14 

Shibata H, Nomori H, Uno K, Sakaguchi K, Nakashima R, Iyama K, Tomiyoshi K, Kaji M, Goya T, Suzuki T and Horio H: 18F-fluorodeoxyglucose and 11C-acetate positron emission tomography are useful modalities for diagnosing the histologic type of thymoma. Cancer. 115:2531–2538. 2009.PubMed/NCBI View Article : Google Scholar

15 

Kaira K, Sunaga N, Ishizuka T, Shimizu K and Yamamoto N: The role of [18F]fluorodeoxyglucose positron emission tomography in thymic epithelial tumors. Cancer Imaging. 11:195–201. 2011.PubMed/NCBI View Article : Google Scholar

16 

Toba H, Kondo K, Sadohara Y, Otsuka H, Morimoto M, Kajiura K, Nakagawa Y, Yoshida M, Kawakami Y, Takizawa H, et al: 18F-fluorodeoxyglucose positron emission tomography/computed tomography and the relationship between fluorodeoxyglucose uptake and the expression of hypoxia-inducible factor-1α, glucose transporter-1 and vascular endothelial growth factor in thymic epithelial tumours. Eur J Cardiothorac Surg. 44:e105–e112. 2013.PubMed/NCBI View Article : Google Scholar

17 

Fukumoto K, Taniguchi T, Ishikawa Y, Kawaguchi K, Fukui T, Kato K, Matsuo K and Yokoi K: The utility of [18F]-fluorodeoxyglucose positron emission tomography-computed tomography in thymic epithelial tumours. Eur J Cardiothorac Surg. 42:e152–e156. 2012.PubMed/NCBI View Article : Google Scholar

18 

Sung YM, Lee KS, Kim BT, Choi JY, Shim YM and Yi CA: 18F-FDG PET/CT of thymic epithelial tumors: Usefulness for distinguishing and staging tumor subgroups. J Nucl Med. 47:1628–1634. 2006.PubMed/NCBI

19 

Seki N, Sakamoto S, Karube Y, Oyaizu T, Ishihama H and Chida M: 18F-fluorodeoxyglucose positron emission tomography for evaluation of thymic epithelial tumors: Utility for world health organization classification and predicting recurrence-free survival. Ann Nucl Med. 28:257–262. 2014.PubMed/NCBI View Article : Google Scholar

20 

Yajima T, Mogi A, Shimizu K, Kosaka T, Ohtaki Y, Obayashi K, Nakazawa S, Nakajima T, Tsushima Y and Shirabe K: Quantitative analysis of metabolic parameters at 18F-fluorodeoxyglucose positron emission tomography in predicting malignant potential of anterior mediastinal tumors. Oncol Lett. 19:1865–1871. 2020.PubMed/NCBI View Article : Google Scholar

21 

Kitami A, Sano F, Ohashi S, Suzuki K, Uematsu S, Suzuki T and Kadokura M: The usefulness of positron-emission tomography findings in the management of anterior mediastinal tumors. Ann Thorac Cardiovasc Surg. 23:26–30. 2017.PubMed/NCBI View Article : Google Scholar

22 

McErlean A, Huang J, Zabor EC, Moskowitz CS and Ginsberg MS: Distinguishing benign thymic lesions from early-stage thymic malignancies on computed tomography. J Thorac Oncol. 8:967–973. 2013.PubMed/NCBI View Article : Google Scholar

23 

Priola SM, Priola AM, Cardinale L, Perotto F and Fava C: The anterior mediastinum: Anatomy and imaging procedures. Radiol Med. 111:295–311. 2006.PubMed/NCBI View Article : Google Scholar

24 

Priola AM, Priola SM, Giraudo MT, Gned D, Fornari A, Ferrero B, Ducco L and Veltri A: Diffusion-weighted magnetic resonance imaging of thymoma: Ability of the apparent diffusion coefficient in predicting the world health organization (WHO) classification and the Masaoka-Koga staging system and its prognostic significance on disease-free survival. Eur Radiol. 26:2126–2138. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yajima T, Mogi A, Yamaki E, Onozato R, Kosaka T, Shirabe K and Kuwano H: Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors. Mol Clin Oncol 13: 85, 2020.
APA
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., & Kuwano, H. (2020). Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors. Molecular and Clinical Oncology, 13, 85. https://doi.org/10.3892/mco.2020.2155
MLA
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., Kuwano, H."Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors". Molecular and Clinical Oncology 13.6 (2020): 85.
Chicago
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., Kuwano, H."Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors". Molecular and Clinical Oncology 13, no. 6 (2020): 85. https://doi.org/10.3892/mco.2020.2155
Copy and paste a formatted citation
x
Spandidos Publications style
Yajima T, Mogi A, Yamaki E, Onozato R, Kosaka T, Shirabe K and Kuwano H: Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors. Mol Clin Oncol 13: 85, 2020.
APA
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., & Kuwano, H. (2020). Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors. Molecular and Clinical Oncology, 13, 85. https://doi.org/10.3892/mco.2020.2155
MLA
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., Kuwano, H."Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors". Molecular and Clinical Oncology 13.6 (2020): 85.
Chicago
Yajima, T., Mogi, A., Yamaki, E., Onozato, R., Kosaka, T., Shirabe, K., Kuwano, H."Advantages of additional PET vs. MRI in the clinical diagnosis of anterior mediastinal tumors". Molecular and Clinical Oncology 13, no. 6 (2020): 85. https://doi.org/10.3892/mco.2020.2155
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