Open Access

Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study

  • Authors:
    • Matthias Kappler
    • Kevin Dauter
    • Waldemar Reich
    • Daniel Bethmann
    • Michael Schwabe
    • Swetlana Rot
    • Claudia Wickenhauser
    • Bilal Al‑Nawas
    • Alexander W. Eckert
  • View Affiliations

  • Published online on: October 21, 2020     https://doi.org/10.3892/mco.2020.2158
  • Article Number: 88
  • Copyright: © Kappler et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In various tumors, epidermal growth factor‑receptor (EGFR) serves a role in tumorigenesis and has an impact on survival. Usually the EGF‑receptor is located on the surface of the cell membrane and is involved in various signaling pathways. The dimerization of EGFR with other ErbB family proteins, such as HER2, is important for the tumor progression. Nevertheless, a second EGFR‑associated signaling pathway appears to be important for tumor cells, which is cytoplasmic/nuclear EGFR. The present study examined the influence of membranous or cytoplasmic localized EGFR on the prognosis of patients with oral squamous cell carcinoma (OSCC). Slides from 45 OSCC tumor samples were stained against EGFR using immunohistochemistry and analysed by the Remmele score system. The association with histopathological parameters and survival data was analyzed. Cytoplasmatic EGFR localization was identified as an independent predictive biomarker for overall survival in the examined OSCC cohort according to multivariate Cox regression analysis. Positive cytoplasmatic EGFR staining was correlated with a higher risk of early death (RR=3.0; P=0.035), while membranous EGFR localization did not affect patient survival. To the best of our knowledge, the present study is the first study to demonstrate that cytoplasmatic‑localized EGFR is an independent prognostic biomarker for the overall survival of patients with OSCC.
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December-2020
Volume 13 Issue 6

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Spandidos Publications style
Kappler M, Dauter K, Reich W, Bethmann D, Schwabe M, Rot S, Wickenhauser C, Al‑Nawas B and Eckert AW: Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study. Mol Clin Oncol 13: 88, 2020
APA
Kappler, M., Dauter, K., Reich, W., Bethmann, D., Schwabe, M., Rot, S. ... Eckert, A.W. (2020). Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study. Molecular and Clinical Oncology, 13, 88. https://doi.org/10.3892/mco.2020.2158
MLA
Kappler, M., Dauter, K., Reich, W., Bethmann, D., Schwabe, M., Rot, S., Wickenhauser, C., Al‑Nawas, B., Eckert, A. W."Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study". Molecular and Clinical Oncology 13.6 (2020): 88.
Chicago
Kappler, M., Dauter, K., Reich, W., Bethmann, D., Schwabe, M., Rot, S., Wickenhauser, C., Al‑Nawas, B., Eckert, A. W."Prognostic impact of cytoplasmatic EGFR upregulation in patients with oral squamous cell carcinoma: A pilot study". Molecular and Clinical Oncology 13, no. 6 (2020): 88. https://doi.org/10.3892/mco.2020.2158