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Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer

  • Authors:
    • Nobuhiro Kanaji
    • Tomoya Ishii
    • Yutaka Ueda
    • Hirohisa Ichikawa
    • Nobuhito Kishimoto
    • Norimitsu Kadowaki
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa 761‑0793, Japan, Department of Respiratory Medicine, Kagawa Prefectural Central Hospital, Takamatsu, Kagawa 760‑8557, Japan, Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations Takamatsu Hospital, Takamatsu, Kagawa 760‑0018, Japan, Department of Pulmonary Medicine, Takamatsu Municipal Hospital, Takamatsu, Kagawa 761‑8538, Japan
    Copyright: © Kanaji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 90
    |
    Published online on: October 23, 2020
       https://doi.org/10.3892/mco.2020.2159
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Abstract

The platinum doublet is considered to be the standard cytotoxic chemotherapy for advanced lung cancer. It has been previously reported that nedaplatin and S‑1 have clinical efficacy against squamous cell lung cancer. As the combination of nedaplatin and S‑1 has never been studied for advanced squamous cell lung cancer, a phase I trial of this combination in the first‑line setting was conducted. Patients who had not received chemotherapy previously, aged ≤75 years and with advanced squamous cell lung cancer were recruited. Nedaplatin was administered intravenously (day 1), and S‑1 was orally administered (days 1‑14) at a fixed dose based on the body surface area (BSA) <1.25 m2, 80 mg/day; BSA=1.25‑1.5 m2, 100 mg/day; and BSA ≥1.5 m2, 120 mg/day. A total of 9 patients were enrolled. The maximum tolerated dose was 80 mg/m2 for nedaplatin. At this dosage, dose‑limiting toxicity was observed in 2 of the 6 patients. A total of one patient experienced grade 3 thrombocytopenia, and the other patient experienced grade 3 anorexia and grade 3 nausea. The recommended dose for phase II studies was determined as being 70 mg/m2 for nedaplatin (clinical trial registration no. UMIN‑CTR UMIN000036387).
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1 

Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J and Johnson DH: Eastern Cooperative Oncology Group. Comparison of four chemotherapy regimens for advanced Non-small-cell lung cancer. N Engl J Med. 346:92–98. 2002.PubMed/NCBI View Article : Google Scholar

2 

Ohe Y, Ohashi Y, Kubota K, Tamura T, Nakagawa K, Negoro S, Nishiwaki Y, Saijo N, Ariyoshi Y and Fukuoka M: Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced Non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol. 18:317–323. 2007.PubMed/NCBI View Article : Google Scholar

3 

Kanaji N, Mizoguchi H, Inoue T, Tadokoro A, Watanabe N, Ishii T, Tojo Y, Yamaguchi M and Kadowaki N: Clinical features of patients with lung cancer accompanied by thromboembolism or disseminated intravascular coagulation. Ther Clin Risk Manag. 14:1361–1368. 2018.PubMed/NCBI View Article : Google Scholar

4 

Van de Ven M, Retèl VP, Koffijberg H, van Harten WH and IJzerman MJ: Variation in the time to treatment for stage III and IV non-small cell lung cancer patients for hospitals in the Netherlands. Lung Cancer. 134:34–41. 2019.PubMed/NCBI View Article : Google Scholar

5 

Kawahara M, Furuse K, Segawa Y, Yoshimori K, Matsui K, Kudoh S, Hasegawa K and Niitani H: S-1 Cooperative Study Group (Lung Cancer Working Group). Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer. Br J Cancer. 85:939–943. 2001.PubMed/NCBI View Article : Google Scholar

6 

Yoshioka H, Okamoto I, Morita S, Ando M, Takeda K, Seto T, Yamamoto N, Saka H, Atagi S, Hirashima T, et al: Efficacy and safety analysis according to histology for S-1 in combination with carboplatin as First-line chemotherapy in patients with advanced Non-small-cell lung cancer: Updated results of the West Japan Oncology Group LETS study. Ann Oncol. 24:1326–1331. 2013.PubMed/NCBI View Article : Google Scholar

7 

Yamamoto N, Tamura T, Kurata T, Yamamoto N, Sekine I, Kunitoh H, Ohe Y and Saijo N: A dose-finding and pharmacokinetic study of nedaplatin in elderly patients with advanced non-small cell lung cancer. Cancer Chemother Pharmacol. 65:79–88. 2009.PubMed/NCBI View Article : Google Scholar

8 

Kodaira T, Fuwa N, Tachibana H and Hidano S: Phase I study of S-1 and nedaplatin for patients with recurrence of head and neck cancer. Anticancer Res. 26:2265–2268. 2006.PubMed/NCBI

9 

Kogashiwa Y, Yamauchi K, Nagafuji H, Matsuda T, Tsubosaka T, Karaho T, Maruyama T and Kohno N: Phase I study of S-1 plus nedaplatin in patients with advanced/recurrent head and neck cancer. Chemotherapy. 56:453–458. 2010.PubMed/NCBI View Article : Google Scholar

10 

Yokoi T, Minami S, Shiroyama T, Koba T, Torii Y, Sugimoto H, Niki M, Mori M, Morimura O, Hirashima T, et al: A Phase II study of Tailored-dose S-1 plus carboplatin followed by maintenance S-1 for advanced squamous cell lung cancer: OSAKA-LCSG 1102. Intern Med. 58:1405–1410. 2019.PubMed/NCBI View Article : Google Scholar

11 

Shukuya T, Yamanaka T, Seto T, Daga H, Goto K, Saka H, Sugawara S, Takahashi T, Yokota S, Kaneda H, et al: Nedaplatin plus docetaxel versus cisplatin plus docetaxel for advanced or relapsed squamous cell carcinoma of the lung (WJOG5208L): A randomised, open-label, phase 3 trial. Lancet Oncol. 16:1630–1638. 2015.PubMed/NCBI View Article : Google Scholar

12 

Tang Y, Wang W, Teng XZ and Shi L: Efficacy of S-1 plus nedaplatin compared to standard second-line chemotherapy in EGFR-negative lung adenocarcinoma after failure of first-line chemotherapy. Tumour Biol. 35:8945–8951. 2014.PubMed/NCBI View Article : Google Scholar

13 

Thatcher N, Hirsch FR, Luft AV, Szczesna A, Ciuleanu TE, Dediu M, Ramlau R, Galiulin RK, Bálint B, Losonczy G, et al: Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): An open-label, randomised, controlled phase 3 trial. Lancet Oncol. 16:763–774. 2015.PubMed/NCBI View Article : Google Scholar

14 

Watanabe S, Yoshioka H, Sakai H, Hotta K, Takenoyama M, Yamada K, Sugawara S, Takiguchi Y, Hosomi Y, Tomii K, et al: Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line treatment for stage IV squamous non-small cell lung cancer: A phase 1b and randomized, open-label, multicenter, phase 2 trial in Japan. Lung Cancer. 129:55–62. 2019.PubMed/NCBI View Article : Google Scholar

15 

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al: Nivolumab versus Docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 373:123–135. 2015.PubMed/NCBI View Article : Google Scholar

16 

Reck M, Rodríguez-Abreu D, Robinson AG, Hui R, Csőszi T, Fülöp A, Gottfried M, Peled N, Tafreshi A, Cuffe S, et al: Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med. 375:1823–1833. 2016.PubMed/NCBI View Article : Google Scholar

17 

Mok TSK, Wu YL, Kudaba I, Kowalski DM, Cho BC, Turna HZ, Castro G Jr, Srimuninnimit V, Laktionov KK, Bondarenko I, et al: Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): A randomised, open-label, controlled, phase 3 trial. Lancet. 393:1819–1830. 2019.PubMed/NCBI View Article : Google Scholar

18 

Paz-Ares L, Luft A, Vicente D, Tafreshi A, Gümüş M, Mazières J, Hermes B, Çay Şenler F, Csőszi T, Fülöp A, et al: Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med. 379:2040–2051. 2018.PubMed/NCBI View Article : Google Scholar

19 

Mazieres J, Kowalski D, Luft A, Vicente D, Tafreshi A, Gümüş M, Laktionov K, Hermes B, Cicin I, Rodríguez-Cid J, et al: Health-related quality of life with carboplatin-paclitaxel or nab-Paclitaxel with or without pembrolizumab in patients with metastatic squamous non-small-cell lung cancer. J Clin Oncol. 38:271–280. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Kanaji N, Ishii T, Ueda Y, Ichikawa H, Kishimoto N and Kadowaki N: Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer. Mol Clin Oncol 13: 90, 2020.
APA
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., & Kadowaki, N. (2020). Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer. Molecular and Clinical Oncology, 13, 90. https://doi.org/10.3892/mco.2020.2159
MLA
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., Kadowaki, N."Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer". Molecular and Clinical Oncology 13.6 (2020): 90.
Chicago
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., Kadowaki, N."Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer". Molecular and Clinical Oncology 13, no. 6 (2020): 90. https://doi.org/10.3892/mco.2020.2159
Copy and paste a formatted citation
x
Spandidos Publications style
Kanaji N, Ishii T, Ueda Y, Ichikawa H, Kishimoto N and Kadowaki N: Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer. Mol Clin Oncol 13: 90, 2020.
APA
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., & Kadowaki, N. (2020). Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer. Molecular and Clinical Oncology, 13, 90. https://doi.org/10.3892/mco.2020.2159
MLA
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., Kadowaki, N."Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer". Molecular and Clinical Oncology 13.6 (2020): 90.
Chicago
Kanaji, N., Ishii, T., Ueda, Y., Ichikawa, H., Kishimoto, N., Kadowaki, N."Phase I trial of nedaplatin and S‑1 in patients with advanced squamous cell lung cancer". Molecular and Clinical Oncology 13, no. 6 (2020): 90. https://doi.org/10.3892/mco.2020.2159
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