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Article

Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma

  • Authors:
    • Elen Cristiane Augusto Souza
    • Daniel Zaidan Santos
    • Jose Carlos Campos Torres
    • Diama Bhadra Vale
    • Joana Froes Bragança
    • Julio Cesar Teixeira
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University of Campinas (UNICAMP), Campinas (SP) 13083‑881, Brazil
  • Article Number: 92
    |
    Published online on: October 26, 2020
       https://doi.org/10.3892/mco.2020.2162
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Abstract

Cervical adenocarcinoma is associated with a poor prognosis, which may be caused by the infiltrative growth pattern and metastasis of tumor cells. There is a lack of consensus on hysterectomy after radiotherapy for the improvement of selected cases. The present study aimed to assess the oncological outcome of post‑radiotherapy hysterectomy in females with cervical adenocarcinoma. A total of 39 females with cervical adenocarcinoma at stages IB1 to IIIB, managed primarily with radiotherapy with complete response, and underwent extrafascial hysterectomy as consolidation therapy between 1988 to 2015 were studied. Surgery complications and residual disease were evaluated. A comparison group was constructed, comprising 41 females with cervical adenocarcinoma managed with exclusive radiotherapy or chemoradiotherapy demonstrating complete response, without surgery. Descriptive and survival analysis was performed. The groups were comparable in terms of age, cancer stage, radiotherapy (dose and duration) and follow‑up, although 67% of hysterectomies were performed prior to 2002 and 46% of the radiotherapy group received chemoradiation. Late complications were similar. There were nine recurrences (23%) in the case series and 10 recurrences (24%) in the radiotherapy group. Residual disease was detected in 56% (22/39) of uterine specimens, of which 12 were up to 10 mm. Residual disease was associated with recurrence (31% vs. 6%, P=0.028). The overall survival rate was 75% for the case series vs. 88% for the radiotherapy group (P=0.579), and the disease‑free survival rate was 79‑80% for both. Removal of residual disease by hysterectomy did not improve the overall survival rate (P=0.283) and disease‑free survival rate (P=0.072). Post‑radiotherapy hysterectomy in cervical adenocarcinoma is a feasible procedure with acceptable complications, however, it did not bring relevant benefits in recurrences, disease‑free survival, and overall survival rates.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

2 

Castellsagué X, Díaz M, de Sanjosé S, Muñoz N, Herrero R, Franceschi S, Peeling RW, Ashley R, Smith JS, Snijders PJ, et al: Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: Implications for screening and prevention. J Natl Cancer Inst. 98:303–315. 2006.PubMed/NCBI View Article : Google Scholar

3 

Teixeira JC, Maestri CA, Machado HDC, Zeferino LC and Carvalho NS: Cervical cancer registered in two developed regions from Brazil: Upper limit of reachable results from opportunistic screening. Rev Bras Ginecol Obstet. 40:347–353. 2018.PubMed/NCBI View Article : Google Scholar

4 

Keys HM, Bundy BN, Stehman FB, Okagaki T, Gallup DG, Burnett AF, Rotman MZ and Fowler WC Jr: Gynecologic Oncology Group. Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: A randomized trial of the gynecologic oncology group. Gynecol Oncol. 89:343–353. 2003.PubMed/NCBI View Article : Google Scholar

5 

Zhou J, Wu SG, Sun JY, Li FY, Lin HX, Chen QH and He ZY: Comparison of clinical outcomes of squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma of the uterine cervix after definitive radiotherapy: A population-based analysis. J Cancer Res Clin Oncol. 143:115–122. 2017.PubMed/NCBI View Article : Google Scholar

6 

Lèguevaque P, Motton S, Delannes M, Querleu D, Soulé-Tholy M, Tap G and Houvenaeghel G: Completion surgery or not after concurrent chemoradiotherapy for locally advanced cervical cancer? Eur J Obstet Gynecol Reprod Biol. 155:188–192. 2011.PubMed/NCBI View Article : Google Scholar

7 

Kaidar-Person O, Yosefia S and Abdah-Bortnyak R: Response of adenocarcinoma of the uterine cervix to chemoradiotherapy. Oncol Lett. 9:2791–2794. 2015.PubMed/NCBI View Article : Google Scholar

8 

Gadducci A, Guerrieri ME and Cosio S: Adenocarcinoma of the uterine cervix: Pathologic features, treatment options, clinical outcome and prognostic variables. Crit Rev Oncol Hematol. 135:103–114. 2019.PubMed/NCBI View Article : Google Scholar

9 

Jonska-Gmyrek J, Gmyrek L, Zolciak-Siwinska A, Kowalska M and Kotowicz B: Adenocarcinoma histology is a poor prognostic factor in locally advanced cervical cancer. Curr Med Res Opin. 35:595–601. 2019.PubMed/NCBI View Article : Google Scholar

10 

Huang YT, Wang CC, Tsai CS, Lai CH, Chang TC, Chou HH, Hsueh S, Chen CK, Lee SP and Hong JH: Long-term outcome and prognostic factors for adenocarcinoma/adenosquamous carcinoma of cervix after definitive radiotherapy. Int J Radiat Oncol Biol Phys. 80:429–436. 2011.PubMed/NCBI View Article : Google Scholar

11 

FIGO Committee on Gynecologic Oncology. FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet. 125:97–98. 2014.PubMed/NCBI View Article : Google Scholar

12 

Odicino F, Pecorelli S, Zigliani L and Creasman WT: History of the FIGO cancer staging system. Int J Gynaecol Obstet. 101:205–210. 2008.PubMed/NCBI View Article : Google Scholar

13 

Mazeron R, Gouy S, Chargari C, Rivin Del Campo E, Dumas I, Mervoyer A, Genestie C, Bentivegna E, Balleyguier C, Pautier P, et al: Post radiation hysterectomy in locally advanced cervical cancer: Outcomes and dosimetric impact. Radiother Oncol. 120:460–466. 2016.PubMed/NCBI View Article : Google Scholar

14 

Hequet D, Marchand E, Place V, Fourchotte V, De La Rochefordière A, Dridi S, Coutant C, Lecuru F, Bats AS, Koskas M, et al: Evaluation and impact of residual disease in locally advanced cervical cancer after concurrent chemoradiation therapy: Results of a multicenter study. Eur J Surg Oncol. 39:1428–1434. 2013.PubMed/NCBI View Article : Google Scholar

15 

Yang J, Shen K, Wang J, Yang J and Cao D: Extrafascial hysterectomy after concurrent chemoradiotherapy in locally advanced cervical adenocarcinoma. J Gynecol Oncol. 27(e40)2016.PubMed/NCBI View Article : Google Scholar

16 

Shi D, Liang Z, Zhang C, Zhang H and Liu X: The effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy: A meta-analysis. BMC Cancer. 18(308)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Souza EC, Santos DZ, Torres JC, Vale DB, Bragança JF and Teixeira JC: Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma. Mol Clin Oncol 13: 92, 2020.
APA
Souza, E.C., Santos, D.Z., Torres, J.C., Vale, D.B., Bragança, J.F., & Teixeira, J.C. (2020). Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma. Molecular and Clinical Oncology, 13, 92. https://doi.org/10.3892/mco.2020.2162
MLA
Souza, E. C., Santos, D. Z., Torres, J. C., Vale, D. B., Bragança, J. F., Teixeira, J. C."Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma". Molecular and Clinical Oncology 13.6 (2020): 92.
Chicago
Souza, E. C., Santos, D. Z., Torres, J. C., Vale, D. B., Bragança, J. F., Teixeira, J. C."Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma". Molecular and Clinical Oncology 13, no. 6 (2020): 92. https://doi.org/10.3892/mco.2020.2162
Copy and paste a formatted citation
x
Spandidos Publications style
Souza EC, Santos DZ, Torres JC, Vale DB, Bragança JF and Teixeira JC: Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma. Mol Clin Oncol 13: 92, 2020.
APA
Souza, E.C., Santos, D.Z., Torres, J.C., Vale, D.B., Bragança, J.F., & Teixeira, J.C. (2020). Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma. Molecular and Clinical Oncology, 13, 92. https://doi.org/10.3892/mco.2020.2162
MLA
Souza, E. C., Santos, D. Z., Torres, J. C., Vale, D. B., Bragança, J. F., Teixeira, J. C."Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma". Molecular and Clinical Oncology 13.6 (2020): 92.
Chicago
Souza, E. C., Santos, D. Z., Torres, J. C., Vale, D. B., Bragança, J. F., Teixeira, J. C."Post‑radiotherapy hysterectomy does not benefit females with cervical adenocarcinoma". Molecular and Clinical Oncology 13, no. 6 (2020): 92. https://doi.org/10.3892/mco.2020.2162
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