A study of 17&nbsp;cases for the identification of prognostic factors for anaplastic thyroid carcinoma

Masui,Takashi; Uemura,Hirokazu; Ota,Ichiro; Kimura,Takahiro; Nishikawa,Daisuke; Yamanaka,Toshiaki; Yane,Katsunari; Kitahara,Tadashi

doi:10.3892/mco.2020.2163

January-2021 Volume 14 Issue 1

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January-2021 Volume 14 Issue 1

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Article

A study of 17 cases for the identification of prognostic factors for anaplastic thyroid carcinoma

Authors:
- Takashi Masui
- Hirokazu Uemura
- Ichiro Ota
- Takahiro Kimura
- Daisuke Nishikawa
- Toshiaki Yamanaka
- Katsunari Yane
- Tadashi Kitahara
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Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Otolaryngology, Kinki University School of Medicine, Nara Hospital, Ikoma, Nara 630‑0293, Japan
Article Number: 1
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Published online on: October 30, 2020

https://doi.org/10.3892/mco.2020.2163
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Abstract

Anaplastic thyroid cancer (ATC) has a poor prognosis. ATC accounts for only 1‑2% of all thyroid carcinomas, yet it is one of the most lethal neoplasms in humans. Notably, there are no established treatment protocols for ATC. The present study investigated the prognostic and predictive factors of ATC. A retrospective analysis was conducted on 17 patients with histologically confirmed ATC. The median overall survival of all patients was 3.8 months. In patients under the age of 70 years, the statistically significant prognostic factors indicating longer survival were the absence of distant metastasis and treatment by radical resection. Furthermore, in contrast to previous findings, tumor size and white blood cell count were not associated with ATC prognosis in the present cohort. Importantly, tracheostomy did not contribute to improvement of prognosis and should perhaps not be considered, when unnecessary, to preserve the patient's quality of life. Prognostic factors for ATC are critical to clinicians to enable them to determine which patients will benefit from aggressive treatment strategies, as opposed to supportive care.

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