Open Access

Impact of postoperative reduced skeletal muscle on prognosis after recurrence in gastric cancer

  • Authors:
    • Keita Kouzu
    • Hironori Tsujimoto
    • Hidekazu Sugasawa
    • Yusuke Ishibashi
    • Yujiro Itazaki
    • Satoshi Tsuchiya
    • Yoji Kishi
    • Hideki Ueno
  • View Affiliations

  • Published online on: October 30, 2020     https://doi.org/10.3892/mco.2020.2165
  • Article Number: 3
  • Copyright: © Kouzu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Little is known about the association between sarcopenia development after gastrectomy and gastric cancer prognosis after recurrence. The present study retrospectively examined the effects of decreased psoas muscle index (PMI) on post‑recurrence prognosis after gastrectomy. A total of 67 patients with gastric cancer recurrence were included in the present study. PMI at pre‑operation and recurrence were calculated, and 25 patients whose PMI reduction rate value was lower than the cutoff values (male=0.766 and female=0.704) were classified into the sarcopenia group and 42 patients into the non‑sarcopenia group. There were no significant differences between the groups regarding age, sex, pathological stage, and nutrition and inflammation indices at the time of recurrence. Post‑recurrence overall survival (OS) was significantly shorter in the sarcopenia group compared with the non‑sarcopenia group (P<0.001). The post‑recurrence survival rate was significantly worse in the sarcopenia group compared with the non‑sarcopenia group (P<0.001). In multivariate analysis, sarcopenia (HR=5.04) and the total courses of chemotherapy after recurrence (HR=3.88) were independent unfavorable prognostic factors. In conclusion, sarcopenia and fewer total courses of post‑recurrence chemotherapy were poor prognostic factors after gastric cancer recurrence. To improve prognosis, preventing sarcopenia development after gastrectomy is required.
View Figures
View References

Related Articles

Journal Cover

January-2021
Volume 14 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kouzu K, Tsujimoto H, Sugasawa H, Ishibashi Y, Itazaki Y, Tsuchiya S, Kishi Y and Ueno H: Impact of postoperative reduced skeletal muscle on prognosis after recurrence in gastric cancer. Mol Clin Oncol 14: 3, 2021
APA
Kouzu, K., Tsujimoto, H., Sugasawa, H., Ishibashi, Y., Itazaki, Y., Tsuchiya, S. ... Ueno, H. (2021). Impact of postoperative reduced skeletal muscle on prognosis after recurrence in gastric cancer. Molecular and Clinical Oncology, 14, 3. https://doi.org/10.3892/mco.2020.2165
MLA
Kouzu, K., Tsujimoto, H., Sugasawa, H., Ishibashi, Y., Itazaki, Y., Tsuchiya, S., Kishi, Y., Ueno, H."Impact of postoperative reduced skeletal muscle on prognosis after recurrence in gastric cancer". Molecular and Clinical Oncology 14.1 (2021): 3.
Chicago
Kouzu, K., Tsujimoto, H., Sugasawa, H., Ishibashi, Y., Itazaki, Y., Tsuchiya, S., Kishi, Y., Ueno, H."Impact of postoperative reduced skeletal muscle on prognosis after recurrence in gastric cancer". Molecular and Clinical Oncology 14, no. 1 (2021): 3. https://doi.org/10.3892/mco.2020.2165