Short‑term outcomes of preoperative chemoradiotherapy with S‑1 for locally advanced rectal cancer

  • Authors:
    • Masatsugu Hiraki
    • Toshiya Tanaka
    • Yoshiki Hiraki
    • Tetsuo Watanabe
    • Hirofumi Sato
    • Hitoshi Aibe
    • Kenji Kitahara
  • View Affiliations

  • Published online on: November 3, 2020     https://doi.org/10.3892/mco.2020.2166
  • Article Number: 4
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Abstract

The purpose of the present study was to evaluate the short‑term results of preoperative chemoradiation therapy with S‑1 for locally advanced rectal cancer. A total of 32 patients with advanced rectal cancer who had been treated with preoperative chemoradiotherapy with S‑1 and underwent surgical resection between May 2012 and December 2019 were analyzed. Advanced rectal cancer of clinical stage II and III was diagnosed in 13 (41%) and 19 (59%) patients, respectively. Therapeutic toxicities of anemia (24 patients; 75%), anal pain (22 patients; 69%) and skin and subcutaneous tissue disorders (19 patients; 59%) were frequently observed in all grades. Grade ≥3 leukopenia, anemia, neutrophil count reduction, platelet count reduction and diarrhea were identified in 2 (6%), 1 (3%), 1 (3%), 1 (3%) and 1 (3%) patients, respectively. A total of 29 patients (91%) completed this therapy without any change to the protocol or dosage. R0 resection was performed in 100% of the patients, and no postoperative mortality was observed. Pathological complete response was observed in 9 cases (28.1%). This therapy can be considered for cases of locally advanced rectal cancer due to its acceptable toxicity and relatively high antitumor effect.
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January-2021
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Spandidos Publications style
Hiraki M, Tanaka T, Hiraki Y, Watanabe T, Sato H, Aibe H and Kitahara K: Short‑term outcomes of preoperative chemoradiotherapy with S‑1 for locally advanced rectal cancer. Mol Clin Oncol 14: 4, 2021
APA
Hiraki, M., Tanaka, T., Hiraki, Y., Watanabe, T., Sato, H., Aibe, H., & Kitahara, K. (2021). Short‑term outcomes of preoperative chemoradiotherapy with S‑1 for locally advanced rectal cancer. Molecular and Clinical Oncology, 14, 4. https://doi.org/10.3892/mco.2020.2166
MLA
Hiraki, M., Tanaka, T., Hiraki, Y., Watanabe, T., Sato, H., Aibe, H., Kitahara, K."Short‑term outcomes of preoperative chemoradiotherapy with S‑1 for locally advanced rectal cancer". Molecular and Clinical Oncology 14.1 (2021): 4.
Chicago
Hiraki, M., Tanaka, T., Hiraki, Y., Watanabe, T., Sato, H., Aibe, H., Kitahara, K."Short‑term outcomes of preoperative chemoradiotherapy with S‑1 for locally advanced rectal cancer". Molecular and Clinical Oncology 14, no. 1 (2021): 4. https://doi.org/10.3892/mco.2020.2166