An aggressive nodular fasciitis lesion protruding from the palm (USP6 gene fusion helps differentiate from sarcomas): A case report

Sawamura,Chigusa; Gokita,Tabu; Ishikawa,Ayataka; Manabe,Jun; Kanda,Hiroaki

doi:10.3892/mco.2020.2172

January-2021 Volume 14 Issue 1

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January-2021 Volume 14 Issue 1

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Case Report

An aggressive nodular fasciitis lesion protruding from the palm (USP6 gene fusion helps differentiate from sarcomas): A case report

Authors:
- Chigusa Sawamura
- Tabu Gokita
- Ayataka Ishikawa
- Jun Manabe
- Hiroaki Kanda
View Affiliations / Copyright

Affiliations: Department of Orthopaedic Surgery, Saitama Cancer Center, Saitama 362‑0806, Japan, Department of Pathology, Saitama Cancer Center, Saitama 362‑0806, Japan
Article Number: 10
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Published online on: November 18, 2020

https://doi.org/10.3892/mco.2020.2172
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Abstract

Nodular fasciitis is a mesenchymal lesion, which has been viewed as a reactive process. The MYH9‑USP6 fusion gene was recently detected in nodular fasciitis, and nodular fasciitis is now considered to be a self‑limiting neoplastic process. Recently, a case of nodular fasciitis that recurred a number of times and metastasized to soft tissues was reported, and the features of aggressive cases of nodular fasciitis are currently under investigation. Here, a case of locally aggressive nodular fasciitis is presented, in which the lesion grew rapidly and caused ulnar nerve palsy. The lesion was locally controlled via marginal excision, and no metastasis was identified at 24 months post‑operation. Histologically, the lesion was consistent with nodular fasciitis, and the detection of the MYH9‑USP6 fusion gene supported the diagnosis. Although most nodular fasciitis lesions are benign, some may be locally aggressive or even metastasize. In the case outlined in the present study, marginal excision was sufficient to locally control the lesion.

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1	Oliveira AM and Chou MM: USP6-induced neoplasms: The biologic spectrum of aneurysmal bone cyst and nodular fasciitis. Hum Pathol. 45:1–11. 2014.PubMed/NCBI View Article : Google Scholar
2	Erickson-Johnson MR, Chou MM, Evers BR, Roth CW, Seys AR, Jin L, Ye Y, Lau AW, Wang X and Oliveira AM: Nodular fasciitis: A novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 91:1427–1433. 2011.PubMed/NCBI View Article : Google Scholar
3	Goldblum JR, Weiss SW and Folpe AL (eds): Benign fibroblastic/myofibroblastic proliferations, including superficial fibromatoses. In: Enzinger and Weiss's Soft Tissue Tumors. 6th edition. Elsevier Health Sciences, Philadelphia, pp188-255, 2013.
4	Guo R, Wang X, Chou MM, Asmann Y, Wenger DE, Al-Ibraheemi A, Molavi DW, Aboulafia A, Jin L, Fritchie K, et al: PPP6R3-USP6 amplification: Novel oncogenic mechanism in malignant nodular fasciitis. Genes Chromosomes Cancer. 55:640–649. 2016.PubMed/NCBI View Article : Google Scholar
5	Kanaya K, Iba K, Yamashita T, Wada T and Hasegawa T: Intraneural nodular fasciitis in a child: A case report and review of the literature. J Hand Surg Am. 41:e299–e302. 2016.PubMed/NCBI View Article : Google Scholar
6	Sevilla JJ, Ares-Rodriguez O, Seijas R and Perez-Dominguez M: Unusual presentation of nodular fasciitis of the hand. A case report. Acta Orthop Belg. 75:141–144. 2009.PubMed/NCBI
7	Al-Qattan MM and Arafah MM: Nodular fasciitis of the hand: Excision preserving ‘vital’ structures. J Hand Surg Eur Vol. 39:881–884. 2014.PubMed/NCBI View Article : Google Scholar
8	Nishida Y, Tsukushi S, Wasa J, Iwata Y, Kozawa E and Ishiguro N: Nodular fasciitis of the finger and hand: Case report. J Hand Surg Am. 35:1184–1186. 2010.PubMed/NCBI View Article : Google Scholar
9	Shin C, Low I, Ng D, Oei P, Miles C and Symmans P: USP6 gene rearrangement in nodular fasciitis and histological mimics. Histopathology. 69:784–791. 2016.PubMed/NCBI View Article : Google Scholar

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

An aggressive nodular fasciitis lesion protruding from the palm (USP6 gene fusion helps differentiate from sarcomas): A case report

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