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Article

Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study

  • Authors:
    • Kenji Kawasumi
    • Azusa Kujirai
    • Reiko Matsui
    • Yohei Kawano
    • Masakazu Yamaguchi
    • Takao Aoyama
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, National Cancer Center Hospital East, Kashiwa, Chiba 277‑8577, Japan, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278‑8511, Japan, Department of Pharmacy, National Cancer Center Hospital, Tokyo 104‑0045, Japan
  • Article Number: 12
    |
    Published online on: November 25, 2020
       https://doi.org/10.3892/mco.2020.2174
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Abstract

The present study assessed the safety of outpatient oral anticancer chemotherapeutic drugs by investigating the type and frequency of serious adverse effects (SAEs). Emergency hospitalization, unplanned consultations and telephone calls were investigated in 1,832 patients who received oral anticancer drug treatment at the National Cancer Center Hospital East between December 1, 2014 and November 30, 2015. Oral cytotoxic anticancer and molecular targeted drugs were administrated to 1,140 (62.2%) and 692 (37.8%) patients, respectively. A total of 52 (2.8%) SAEs were reported, with 32 (2.8%) occurring following cytotoxic anticancer drug administration and 20 (2.9%) occurring after molecular targeted drug treatment. The most common SAE was gastrointestinal toxicity. The median time to SAE occurrence was 32 days (range, 5‑1,705 days). The rate of unplanned consultations and telephone calls were 5.5 and 37.9% among all patients, respectively, with skin reactions being the most common reason for unplanned consultations. SAEs often occurred early after treatment initiation. It was concluded that measures against gastrointestinal toxicity are particularly important were administering chemotherapeutic agents.
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Copy and paste a formatted citation
Spandidos Publications style
Kawasumi K, Kujirai A, Matsui R, Kawano Y, Yamaguchi M and Aoyama T: Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study. Mol Clin Oncol 14: 12, 2021.
APA
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., & Aoyama, T. (2021). Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study. Molecular and Clinical Oncology, 14, 12. https://doi.org/10.3892/mco.2020.2174
MLA
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., Aoyama, T."Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study". Molecular and Clinical Oncology 14.1 (2021): 12.
Chicago
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., Aoyama, T."Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study". Molecular and Clinical Oncology 14, no. 1 (2021): 12. https://doi.org/10.3892/mco.2020.2174
Copy and paste a formatted citation
x
Spandidos Publications style
Kawasumi K, Kujirai A, Matsui R, Kawano Y, Yamaguchi M and Aoyama T: Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study. Mol Clin Oncol 14: 12, 2021.
APA
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., & Aoyama, T. (2021). Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study. Molecular and Clinical Oncology, 14, 12. https://doi.org/10.3892/mco.2020.2174
MLA
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., Aoyama, T."Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study". Molecular and Clinical Oncology 14.1 (2021): 12.
Chicago
Kawasumi, K., Kujirai, A., Matsui, R., Kawano, Y., Yamaguchi, M., Aoyama, T."Survey of serious adverse events and safety evaluation of oral anticancer drug treatment in Japan: A retrospective study". Molecular and Clinical Oncology 14, no. 1 (2021): 12. https://doi.org/10.3892/mco.2020.2174
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