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Molecular and Clinical Oncology
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Case Report Open Access

Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature

  • Authors:
    • Rui Bai
    • Zhen-Qun Zhao
    • Yu-Xin Wang
    • Wei Zhao
    • Li-Shuan Wu
    • Shu-Xia Cui
    • Shi-Bing Guo
    • Chen-Liang Liang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010030, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 17
    |
    Published online on: November 26, 2020
       https://doi.org/10.3892/mco.2020.2179
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Abstract

Chordoma is a sporadic type of cancer that affects the spine and is particularly challenging to treat due to the paucity of reported cases and scientific literature. In particular, primary chordomas affecting both the sacral and thoracic vertebrae are extremely rare. We herein report a rare case of chordoma in the sacral and thoracic vertebrae with pulmonary metastasis, along with a literature review. The objective of the present study was to explore treatment options and long‑term outcomes in patients with metastatic chordoma. Posterior decompression was performed for the thoracic tumor, followed by extended resection of the sacral tumor. The symptoms of the patient were relieved after surgery, and the postoperative Nurick score decreased from grade 3 to grade 2, while the postoperative McCormick score was I. Therefore, complete chordoma excision and internal spinal fixation may effectively reduce tumor recurrence and metastasis.
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1 

Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT and Ferreira MJ: Chordoma: Current concepts, management, and future directions. Lancet Oncol. 13:e69–e76. 2012.PubMed/NCBI View Article : Google Scholar

2 

Ropper AE, Cahill KS, Hanna JW, McCarthy EF, Gokaslan ZL and Chi JH: Primary vertebral tumors: A review of epidemiologic, histological and imaging findings, part II: Locally aggressive and malignant tumors. Neurosurgery. 70:211–219. 2012.PubMed/NCBI View Article : Google Scholar

3 

Chambers KJ, Lin DT, Meier J, Remenschneider A, Herr M and Gray ST: Incidence and survival patterns of cranial chordoma in the United States. Laryngoscope. 124:1097–1102. 2014.PubMed/NCBI View Article : Google Scholar

4 

McMaster ML, Goldstein AM, Bromley CM, Ishibe N and Parry DM: Chordoma: Incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control. 12:1–11. 2001.PubMed/NCBI View Article : Google Scholar

5 

Sciubba DM, Chi JH, Rhines LD and Gokaslan ZL: Chordoma of the spinal column. Neurosurg Clin N Am. 19:5–15. 2008.PubMed/NCBI View Article : Google Scholar

6 

Jahangiri A, Jian B, Miller L, El-Sayed IH and Aghi MK: Skull base chordomas: Clinical features, prognostic factors, and therapeutics. Neurosurg Clin N Am. 24:79–88. 2013.PubMed/NCBI View Article : Google Scholar

7 

Chugh R, Tawbi H, Lucas DR, Biermann JS, Schuetze SM and Baker LH: Chordoma: The non sarcoma primary bone tumor. Oncologist. 12:1344–1350. 2007.PubMed/NCBI View Article : Google Scholar

8 

Fuchs B, Dickey ID, Yaszemski MJ, Inwards CY and Sim FH: Operative management of sacral chordoma. J Bone Joint Surg Am. 87:2211–2216. 2005.PubMed/NCBI View Article : Google Scholar

9 

Bongers MER, Dea N, Ames CP and Schwab JH: Surgical strategies for chordoma. Neurosurg Clin N Am. 31:251–261. 2020.PubMed/NCBI View Article : Google Scholar

10 

D'Amore T, Boyce B and Mesfin A: Chordoma of the mobile spine and sacrum: Clinical management and prognosis. J Spine Surg. 4:546–552. 2018.PubMed/NCBI View Article : Google Scholar

11 

Alan O, Akin Telli T, Ercelep O, Tanrikulu Simsek E, Basoglu Tuylu T, Mutis A, Hasanov R, Kaya S, Akgül Babacan N, Dane F and Yumuk PF: Chordoma: A case series and review of the literature. J Med Case Rep. 12(239)2018.PubMed/NCBI View Article : Google Scholar

12 

Vellutini EAS, Brock RS, Martins HO, Taricco MA and de Oliveira MF: Diffuse spinal spreading following previous intracranial intradural chordoma resection: A rare case report. J Clin Neurosci. 64:44–46. 2019.PubMed/NCBI View Article : Google Scholar

13 

Akmansu M, Kurt G, Demircan V and Senturk E: Results of chordoma patients treated by different approaches in a single institution. Turk Neurosurg. 30:366–370. 2020.PubMed/NCBI View Article : Google Scholar

14 

Ahmed R, Sheybani A, Menezes AH, Buatti JM and Hitchon PW: Disease outcomes for skull base and spinal chordomas: A single center experience. Clin Neurol Neurosurg. 130:67–73. 2015.PubMed/NCBI View Article : Google Scholar

15 

Pu F, Wang B, Liu J, Chen F and Shao Z: Giant chordoma in the thoracolumbar spine: A case report and literature review. Eur Spine J. 26 (Suppl 1):S95–S99. 2017.PubMed/NCBI View Article : Google Scholar

16 

Colangeli S, Muratori F, Bettini L, Frenos F, Totti F, D'Arienzo A, Campo FR, Scoccianti G, Beltrami G, Campanacci DA and Capanna R: Surgical treatment of sacral chordoma: En bloc resection with negative margins is a determinant of the long-term outcome. Surg Technol Int. 33:343–348. 2018.PubMed/NCBI

17 

Niu XH: Interpretation of 2020 NCCN clinical practice guidelines in oncology-bone cancer. Zhonghua Wai Ke Za Zhi. 58:430–434. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).

18 

Ruggieri P, Angelini A, Ussia G, Montalti M and Mercuri M: Surgical margins and local control in resection of sacral chordomas. Clin Orthop Relat Res. 468:2939–2947. 2010.PubMed/NCBI View Article : Google Scholar

19 

Mohanty S, Pai Kanhangad M and Kundangar R: The extended posterior approach for resection of sacral tumours. Eur Spine J. 28:1461–1467. 2019.PubMed/NCBI View Article : Google Scholar

20 

Yang Y, Li Y, Liu W, Xu H and Niu X: The clinical outcome of recurrent sacral chordoma with further surgical treatment. Medicine (Baltimore). 97(e13730)2018.PubMed/NCBI View Article : Google Scholar

21 

Kabolizadeh P, Chen YL, Liebsch N, Hornicek FJ, Schwab JH, Choy E, Rosenthal DI, Niemierko A and DeLaney TF: Updated outcome and analysis of tumor response in mobile spine and sacral chordoma treated with definitive high-dose photon/proton radiation therapy. Int J Radiat Oncol Biol Phys. 97:254–262. 2017.PubMed/NCBI View Article : Google Scholar

22 

Imai R, Kamada T, Tsuji H, Sugawara S, Serizawa I, Tsujii H and Tatezaki S: Working Group for Bone and Soft Tissue Sarcomas. Effect of carbon ion radiotherapy for sacral chordoma: Results of Phase I-II and Phase II clinical trials. Int J Radiat Oncol Biol Phys. 77:1470–1476. 2010.PubMed/NCBI View Article : Google Scholar

23 

Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, Rosenberg AE, Rosenthal DI and Suit HD: Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 65:1514–1521. 2006.PubMed/NCBI View Article : Google Scholar

24 

Chen YL, Liebsch N, Kobayashi W, Goldberg S, Kirsch D, Calkins G, Childs S, Schwab J, Hornicek F and DeLaney T: Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine (Phila Pa 1976). 38:E930–E936. 2013.PubMed/NCBI View Article : Google Scholar

25 

Bompas E, Le Cesne A, Tresch-Bruneel E, Lebellec L, Laurence V, Collard O, Saada-Bouzid E, Isambert N, Blay JY, Amela EY, et al: Sorafenib in patients with locally advanced and metastatic chordomas: a phase II trial of the French Sarcoma Group (GSF/GETO). Ann Oncol. 26:2168–2173. 2015.PubMed/NCBI View Article : Google Scholar

26 

Lebellec L, Bertucci F, Tresch-Bruneel E, Bompas E, Toiron Y, Camoin L, Mir O, Laurence V, Clisant S, Decoupigny E, et al: Circulating vascular endothelial growth factor (VEGF) as predictive factor of progression-free survival in patients with advanced chordoma receiving sorafenib: An analysis from a phase II trial of the French sarcoma group (GSF/GETO). Oncotarget. 7:73984–73994. 2016.PubMed/NCBI View Article : Google Scholar

27 

Stacchiotti S, Longhi A, Ferraresi V, Grignani G, Comandone A, Stupp R, Bertuzzi A, Tamborini E, Pilotti S, Messina A, et al: Phase II study of imatinib in advanced chordoma. J Clin Oncol. 30:914–920. 2012.PubMed/NCBI View Article : Google Scholar

28 

George S, Merriam P, Maki RG, Van den Abbeele AD, Yap JT, Akhurst T, Harmon DC, Bhuchar G, O'Mara MM, D'Adamo DR, et al: Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol. 27:3154–3160. 2009.PubMed/NCBI View Article : Google Scholar

29 

Stacchiotti S, Marrari A, Tamborini E, Palassini E, Virdis E, Messina A, Crippa F, Morosi C, Gronchi A, Pilotti S and Casali PG: Response to imatinib plus sirolimus in advanced chordoma. Ann Oncol. 20:1886–1894. 2009.PubMed/NCBI View Article : Google Scholar

30 

Meng T, Jin J, Jiang C, Huang R, Yin H, Song D and Cheng L: Molecular targeted therapy in the treatment of chordoma: A systematic review. Front Oncol. 9(30)2019.PubMed/NCBI View Article : Google Scholar

31 

Liu C, Jia Q, Wei H, Yang X, Liu T, Zhao J, Ling Y, Wang C, Yu H, Li Z, et al: Apatinib in patients with advanced chordoma: A single-arm, single-centre, phase 2 study. Lancet Oncol. 21:1244–1252. 2020.PubMed/NCBI View Article : Google Scholar

32 

Stacchiotti S and Sommer J: Chordoma Global Consensus Group. Building a global consensus approach to chordoma: A position paper from the medical and patient community. Lancet Oncol. 16:e71–e83. 2015.PubMed/NCBI View Article : Google Scholar

33 

Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, et al: Best practices for the management of local-regional recurrent chordoma: A position paper by the chordoma global consensus group. Ann Oncol. 28:1230–1242. 2017.PubMed/NCBI View Article : Google Scholar

34 

Colia V and Stacchiotti S: Medical treatment of advanced chordomas. Eur J Cancer. 83:220–228. 2017.PubMed/NCBI View Article : Google Scholar

35 

Ji T, Guo W, Yang R, Tang X, Wang Y and Huang L: What are the conditional survival and functional outcomes after surgical treatment of 115 patients with sacral chordoma? Clin Orthop Relat Res. 475:620–630. 2017.PubMed/NCBI View Article : Google Scholar

36 

Yang Y, Niu X, Li Y, Liu W and Xu H: Recurrence and survival factors analysis of 171 cases of sacral chordoma in a single institute. Eur Spine J. 26:1910–1916. 2017.PubMed/NCBI View Article : Google Scholar

37 

Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, et al: Prognostic factors in patients with spinal chordoma: An integrative analysis of 682 patients. Neurosurgery. 81:812–823. 2017.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Bai R, Zhao Z, Wang Y, Zhao W, Wu L, Cui S, Guo S and Liang C: Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature. Mol Clin Oncol 14: 17, 2021.
APA
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S. ... Liang, C. (2021). Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature. Molecular and Clinical Oncology, 14, 17. https://doi.org/10.3892/mco.2020.2179
MLA
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S., Guo, S., Liang, C."Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature". Molecular and Clinical Oncology 14.1 (2021): 17.
Chicago
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S., Guo, S., Liang, C."Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature". Molecular and Clinical Oncology 14, no. 1 (2021): 17. https://doi.org/10.3892/mco.2020.2179
Copy and paste a formatted citation
x
Spandidos Publications style
Bai R, Zhao Z, Wang Y, Zhao W, Wu L, Cui S, Guo S and Liang C: Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature. Mol Clin Oncol 14: 17, 2021.
APA
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S. ... Liang, C. (2021). Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature. Molecular and Clinical Oncology, 14, 17. https://doi.org/10.3892/mco.2020.2179
MLA
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S., Guo, S., Liang, C."Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature". Molecular and Clinical Oncology 14.1 (2021): 17.
Chicago
Bai, R., Zhao, Z., Wang, Y., Zhao, W., Wu, L., Cui, S., Guo, S., Liang, C."Sacral and thoracic chordoma with pulmonary metastases: A case report and review of the literature". Molecular and Clinical Oncology 14, no. 1 (2021): 17. https://doi.org/10.3892/mco.2020.2179
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