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VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma

  • Authors:
    • Yinhai Xu
    • Zhao Liu
    • Ham Li
    • Shoujie Feng
    • Qingpeng Li
    • Junfeng Li
    • Shibao Li
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Thyroid and Breast Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, School of Foreign Studies, Jiangsu Normal University, Xuzhou, Jiangsu 221116, P.R. China, Department of Thoracic Cardiovascular Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China, Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
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    Published online on: December 9, 2020
       https://doi.org/10.3892/mco.2020.2187
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Abstract

Although the incidence of lung cancer is increasing worldwide, the molecular mechanisms for its tumorigenesis, progression and prognosis remain unknown. As a member of the tumor necrosis factor superfamily, vascular endothelial growth inhibitor (VEGI) is involved in the development and progression of many malignant diseases. In the present study, the expression of VEGI and CD31 was examined via immunohistochemistry in non‑small cell lung cancer (NSCLC) tissues obtained from 150 patients with NSCLC. The inhibitory effect of VEGI on tumor‑associated blood vessel formation and growth was investigated by determining the relationship between VEGI protein expression and microvascular density (MVD). Prognostic significance was evaluated using the Kaplan‑Meier method. VEGI expression was downregulated or lost in 68.7% (103/150) of patients with NSCLC, an effect that was more prevalent in adenocarcinoma (AC), 76.0% (57/75), than in squamous cell carcinoma, 61.3% (46/75). A significant negative correlation was indentified between VEGI expression and lymphovascular invasion (P=0.039) and lymph node metastasis (P=0.017) in AC tissue. Additionally, MVD was significantly lower in the VEGI‑rich group compared with the VEGI‑poor group. The downregulation of VEGI expression was also associated with poorer overall survival (P=0.011) in patients with AC. The present study therefore provides evidence that VEGI may be a new and effective prognostic marker of lung AC.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Liu Z, Li H, Feng S, Li Q, Li J and Li S: VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma. Mol Clin Oncol 14: 25, 2021.
APA
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., & Li, S. (2021). VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma. Molecular and Clinical Oncology, 14, 25. https://doi.org/10.3892/mco.2020.2187
MLA
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., Li, S."VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma". Molecular and Clinical Oncology 14.2 (2021): 25.
Chicago
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., Li, S."VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma". Molecular and Clinical Oncology 14, no. 2 (2021): 25. https://doi.org/10.3892/mco.2020.2187
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Liu Z, Li H, Feng S, Li Q, Li J and Li S: VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma. Mol Clin Oncol 14: 25, 2021.
APA
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., & Li, S. (2021). VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma. Molecular and Clinical Oncology, 14, 25. https://doi.org/10.3892/mco.2020.2187
MLA
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., Li, S."VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma". Molecular and Clinical Oncology 14.2 (2021): 25.
Chicago
Xu, Y., Liu, Z., Li, H., Feng, S., Li, Q., Li, J., Li, S."VEGI downregulation is correlated with nodal metastasis and poor prognosis in lung adenocarcinoma". Molecular and Clinical Oncology 14, no. 2 (2021): 25. https://doi.org/10.3892/mco.2020.2187
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