Open Access

Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations

  • Authors:
    • Masaru Fukahori
    • Ken Kato
    • Hirokazu Taniguchi
    • Rie Ohtomo
    • Naoki Takahashi
    • Hirokazu Shoji
    • Satoru Iwasa
    • Yoshitaka Honma
    • Atsuo Takashima
    • Tetsuya Hamaguchi
    • Yasuhide Yamada
    • Yasuhiro Shimada
    • Yoshinori Ito
    • Jun Itami
    • Nobukazu Hokamura
    • Hiroyasu Igaki
    • Yuji Tachimori
    • Keisuke Miwa
    • Takuji Torimura
    • Narikazu Boku
  • View Affiliations

  • Published online on: December 30, 2020     https://doi.org/10.3892/mco.2020.2205
  • Article Number: 41
  • Copyright: © Fukahori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cervical esophageal squamous cell carcinoma (CESCC) is rare, accounting for 5% of all esophageal carcinomas. Several diagnostic and predictive markers have been studied. However, to the best of our knowledge, no biomarker is known to determine patient management except the clinical stage. The present study aimed to evaluate whether human papilloma virus (HPV) infection, epidermal growth factor receptor (EGFR) and its pathway‑related gene mutations, known to be sensitive biomarkers of oropharyngeal carcinomas, could be used as biomarkers for the prediction of the prognosis of patients with CESCC. The present retrospective study included patients with CESCC who received chemoradiotherapy or surgery. HPV infection and the genomic status of EGFR, KRAS, BRAF, NRAS and PIK3CA of each tumor sample from patients with CESCC were analyzed by in situ hybridizations (ISH) and PCR methods, respectively. The present study included 33 patients with CESCC (male/female, 29/4; median age, 62 years; age range, 41‑86 years; clinical stage I/II/III/IV, 2/6/10/15). The present study detected HPV in one patient (3.0%) by ISH and PCR. Concerning the investigation of EGFR and its pathway‑related gene mutations, the present study detected 15.1% of EGFR, 6.0% of NRAS, 3.5% of BRAF, 3.0% of KRAS and 3.0% for PIK3CA mutations, with no significant relationship between any gene mutations and the clinical prognostic factors. The HPV‑infected patient did not exhibit any gene mutations. The present study indicated that HPV infection, EGFR and its pathway‑related gene mutations rarely exist in patients with CESCC. The relationship between these biomarkers and the prognosis in patients with CESCC is still unclear.
View Figures
View References

Related Articles

Journal Cover

February-2021
Volume 14 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fukahori M, Kato K, Taniguchi H, Ohtomo R, Takahashi N, Shoji H, Iwasa S, Honma Y, Takashima A, Hamaguchi T, Hamaguchi T, et al: Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations. Mol Clin Oncol 14: 41, 2021
APA
Fukahori, M., Kato, K., Taniguchi, H., Ohtomo, R., Takahashi, N., Shoji, H. ... Boku, N. (2021). Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations. Molecular and Clinical Oncology, 14, 41. https://doi.org/10.3892/mco.2020.2205
MLA
Fukahori, M., Kato, K., Taniguchi, H., Ohtomo, R., Takahashi, N., Shoji, H., Iwasa, S., Honma, Y., Takashima, A., Hamaguchi, T., Yamada, Y., Shimada, Y., Ito, Y., Itami, J., Hokamura, N., Igaki, H., Tachimori, Y., Miwa, K., Torimura, T., Boku, N."Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations". Molecular and Clinical Oncology 14.2 (2021): 41.
Chicago
Fukahori, M., Kato, K., Taniguchi, H., Ohtomo, R., Takahashi, N., Shoji, H., Iwasa, S., Honma, Y., Takashima, A., Hamaguchi, T., Yamada, Y., Shimada, Y., Ito, Y., Itami, J., Hokamura, N., Igaki, H., Tachimori, Y., Miwa, K., Torimura, T., Boku, N."Relationship between cervical esophageal squamous cell carcinoma and human papilloma virus infection and gene mutations". Molecular and Clinical Oncology 14, no. 2 (2021): 41. https://doi.org/10.3892/mco.2020.2205