Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors

  • Authors:
    • Shigeo Takahashi
    • Masahide Anada
    • Toshifumi Kinoshita
    • Takamasa Nishide
    • Shohei Kozai
    • Toru Shibata
  • View Affiliations

  • Published online on: January 21, 2021     https://doi.org/10.3892/mco.2021.2215
  • Article Number: 53
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Abstract

The purpose of the present retrospective study was to evaluate the feasibility of hippocampal dose‑volume parameters associated with memory decline for intensity‑modulated radiotherapy (IMRT). In total, 18 patients who underwent IMRT for supratentorial tumors were analyzed. Prescribed doses of IMRT in 30 fractions were 60 Gy to planning target volume (PTV) 1 of the local area and 48‑51 Gy to PTV2 of the extended local area. Based on previous literature, the present study investigated dose‑volume parameters of the bilateral hippocampi: D40% of 13.1 Gy, D50% of 29.6 Gy, and V55Gy of 5.0%. It was evaluated which of the parameters was most achievable, and unfavorable factors that interfere with reaching these parameters were identified. As a result, D40% of 13.1 Gy, D50% of 29.6 Gy and V55Gy of 5.0% were achieved in 17, 67 and 33% of patients, respectively. For D50% of 29.6 Gy, PTV2 ≥500 cc (P=0.004) and tumor in temporal/corpus callosum/basal ganglia (P=0.009) were significant unfavorable factors. In conclusion, D50% of 29.6 Gy was most achievable. In daily clinical practice, it should be primarily attempted to achieve D50% of 29.6 Gy of the bilateral hippocampi.
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March-2021
Volume 14 Issue 3

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Spandidos Publications style
Takahashi S, Anada M, Kinoshita T, Nishide T, Kozai S and Shibata T: Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors. Mol Clin Oncol 14: 53, 2021
APA
Takahashi, S., Anada, M., Kinoshita, T., Nishide, T., Kozai, S., & Shibata, T. (2021). Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors. Molecular and Clinical Oncology, 14, 53. https://doi.org/10.3892/mco.2021.2215
MLA
Takahashi, S., Anada, M., Kinoshita, T., Nishide, T., Kozai, S., Shibata, T."Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors". Molecular and Clinical Oncology 14.3 (2021): 53.
Chicago
Takahashi, S., Anada, M., Kinoshita, T., Nishide, T., Kozai, S., Shibata, T."Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors". Molecular and Clinical Oncology 14, no. 3 (2021): 53. https://doi.org/10.3892/mco.2021.2215