Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors

Takahashi,Shigeo; Anada,Masahide; Kinoshita,Toshifumi; Nishide,Takamasa; Kozai,Shohei; Shibata,Toru

doi:10.3892/mco.2021.2215

March-2021 Volume 14 Issue 3

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March-2021 Volume 14 Issue 3

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Article

Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors

Authors:
- Shigeo Takahashi
- Masahide Anada
- Toshifumi Kinoshita
- Takamasa Nishide
- Shohei Kozai
- Toru Shibata
View Affiliations / Copyright

Affiliations: Department of Radiation Oncology, Kagawa University Hospital, Kita, Kagawa 761‑0793, Japan
Article Number: 53
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Published online on: January 21, 2021

https://doi.org/10.3892/mco.2021.2215
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Abstract

The purpose of the present retrospective study was to evaluate the feasibility of hippocampal dose‑volume parameters associated with memory decline for intensity‑modulated radiotherapy (IMRT). In total, 18 patients who underwent IMRT for supratentorial tumors were analyzed. Prescribed doses of IMRT in 30 fractions were 60 Gy to planning target volume (PTV) 1 of the local area and 48‑51 Gy to PTV2 of the extended local area. Based on previous literature, the present study investigated dose‑volume parameters of the bilateral hippocampi: D_40% of 13.1 Gy, D_50% of 29.6 Gy, and V_55Gy of 5.0%. It was evaluated which of the parameters was most achievable, and unfavorable factors that interfere with reaching these parameters were identified. As a result, D_40% of 13.1 Gy, D_50% of 29.6 Gy and V_55Gy of 5.0% were achieved in 17, 67 and 33% of patients, respectively. For D_50% of 29.6 Gy, PTV2 ≥500 cc (P=0.004) and tumor in temporal/corpus callosum/basal ganglia (P=0.009) were significant unfavorable factors. In conclusion, D_50% of 29.6 Gy was most achievable. In daily clinical practice, it should be primarily attempted to achieve D50% of 29.6 Gy of the bilateral hippocampi.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Feasibility of hippocampal dose‑volume parameters associated with memory decline in intensity‑modulated radiotherapy for supratentorial tumors

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