Open Access

Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report

  • Authors:
    • Minjie Zhu
    • Jianchang Shu
    • Xuyou Liu
    • Lei Leng
    • Qi Wen
  • View Affiliations

  • Published online on: January 25, 2021     https://doi.org/10.3892/mco.2021.2224
  • Article Number: 62
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present case study reported a rare case of duodenal metastasis from a lung adenocarcinoma. A 62‑year‑old male, who underwent radical lung cancer surgery two years ago, was readmitted to Guangzhou Red Cross Hospital complaining of epigastric pain. The esophagogastroduodenoscopy identified a 2.5x3.5 cm ulcerative lesion at the duodenum. Histopathological and immunohistochemical staining results confirmed that the lung adenocarcinoma had metastasized to the duodenum. The tumor cells were positive for cytokeratin‑7, thyroid transcription factor‑1 and napsin‑A expression, but negative for caudal‑related homeobox 2 expression. Prior to the second cycle of targeted treatment with anlotinib, the patient reported severe hematochezia. Therefore, an angiography and artery embolization were subsequently performed. However, the patient succumbed to acute kidney injury three days after the operation. The metastasis of lung cancer to the gastrointestinal tract is extremely rare and usually asymptomatic. However, when treating patients with lung cancer presenting with digestive symptoms or other distant metastatic sites, clinicians should consider the possibility of gastrointestinal metastasis so that it can be identified in a timely manner. If lesions exist, doctors should locate these and perform biopsies to conduct histopathological and immunohistochemical examinations to make a clear diagnosis.
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March-2021
Volume 14 Issue 3

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Spandidos Publications style
Zhu M, Shu J, Liu X, Leng L and Wen Q: Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report. Mol Clin Oncol 14: 62, 2021
APA
Zhu, M., Shu, J., Liu, X., Leng, L., & Wen, Q. (2021). Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report. Molecular and Clinical Oncology, 14, 62. https://doi.org/10.3892/mco.2021.2224
MLA
Zhu, M., Shu, J., Liu, X., Leng, L., Wen, Q."Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report". Molecular and Clinical Oncology 14.3 (2021): 62.
Chicago
Zhu, M., Shu, J., Liu, X., Leng, L., Wen, Q."Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report". Molecular and Clinical Oncology 14, no. 3 (2021): 62. https://doi.org/10.3892/mco.2021.2224