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Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition

  • Authors:
    • Kenzo Sonoda
    • Tatsuhiro Ohgami
    • Masahiro Hachisuga
    • Yasuyuki Fujita
    • Kaoru Okugawa
    • Hideaki Yahata
    • Kiyoko Kato
  • View Affiliations / Copyright

    Affiliations: Gynecology Service, National Hospital Organization Kyushu Cancer Center, Fukuoka 811‑1395, Japan, Department of Obstetrics and Gynecology, Graduate School of Medical Sciences and University Hospital, Fukuoka 812‑8582, Japan
    Copyright: © Sonoda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 67
    |
    Published online on: February 8, 2021
       https://doi.org/10.3892/mco.2021.2229
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Abstract

Due to the recent trend of women having children at an older age, the number of pregnancies complicated by cervical cancer has increased. In the present study, the clinical characteristics of patients with cervical cancer complicated by pregnancy were analyzed. The clinicopathological characteristics and prognosis of patients with cervical cancer during pregnancy who underwent treatment at Kyushu University Hospital from January 2008 to December 2017 were assessed retrospectively from their medical records. The medical information of patients diagnosed within 6 months after parturition was also evaluated as these patients were considered to be affected by cervical cancer during pregnancy. A total of 19 women were diagnosed with cervical cancer during pregnancy (median age, 33 years), three of whom were diagnosed as negative for intraepithelial lesion or malignancy at the initial visit to a previous clinic after pregnancy. The tumor stage was IA1 in one patient, IB1 in 16 patients, IB2 in one patient and IVB in one patient. The median gestational age at the time of cervical cancer diagnosis was 13 weeks. One patient died of cervical cancer during the follow‑up period. An additional 12 patients were diagnosed within 6 months after parturition. The median age of these patients was 35.5 years. Cancer screening was performed in 10 patients during pregnancy, none of whom were diagnosed with cervical cancer, including three patients who were negative for intraepithelial lesion or malignancy. Of the 12 patients, one had tumor stage IA1, eight had IB1, two had IB2 and one had IIB. Three patients experienced recurrence, of whom one died of cervical cancer. Advanced cervical cancer was diagnosed both during pregnancy and within 6 months after parturition. Diagnosis of cervical cancer during pregnancy is difficult even at an advanced stage; however, rapid diagnosis and prompt multidisciplinary treatment are critical. Therefore, it is necessary to improve the accuracy of cervical cancer diagnosis, and to characterize tumor cells and their microenvironment, during pregnancy.
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Copy and paste a formatted citation
Spandidos Publications style
Sonoda K, Ohgami T, Hachisuga M, Fujita Y, Okugawa K, Yahata H and Kato K: Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition. Mol Clin Oncol 14: 67, 2021.
APA
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., & Kato, K. (2021). Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition. Molecular and Clinical Oncology, 14, 67. https://doi.org/10.3892/mco.2021.2229
MLA
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., Kato, K."Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition". Molecular and Clinical Oncology 14.4 (2021): 67.
Chicago
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., Kato, K."Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition". Molecular and Clinical Oncology 14, no. 4 (2021): 67. https://doi.org/10.3892/mco.2021.2229
Copy and paste a formatted citation
x
Spandidos Publications style
Sonoda K, Ohgami T, Hachisuga M, Fujita Y, Okugawa K, Yahata H and Kato K: Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition. Mol Clin Oncol 14: 67, 2021.
APA
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., & Kato, K. (2021). Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition. Molecular and Clinical Oncology, 14, 67. https://doi.org/10.3892/mco.2021.2229
MLA
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., Kato, K."Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition". Molecular and Clinical Oncology 14.4 (2021): 67.
Chicago
Sonoda, K., Ohgami, T., Hachisuga, M., Fujita, Y., Okugawa, K., Yahata, H., Kato, K."Difficulty of cervical cancer diagnosis during pregnancy: A case series analysis of the clinicopathological characteristics and prognosis of cervical cancer diagnosed during pregnancy or within 6 months after parturition". Molecular and Clinical Oncology 14, no. 4 (2021): 67. https://doi.org/10.3892/mco.2021.2229
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