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Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma

  • Authors:
    • Shigeo Maruyama
    • Masahiko Koda
    • Tomomitsu Matono
    • Hajime Isomoto
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Maruyama Medical Clinic, Hamada, Shimane 697‑0034, Japan, Department of Internal Medicine, Hino Hospital, Hino, Tottori 689‑4504, Japan, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8504, Japan
    Copyright: © Maruyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 83
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    Published online on: February 26, 2021
       https://doi.org/10.3892/mco.2021.2245
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Abstract

Little is known concerning causal factors associated with the size and echogenicity of hepatic hemangiomas. The aim of the present study was to investigate the associations between tumor size and echo pattern and coagulation factors, and to elucidate the growth pattern of hemangiomas. In 214 consecutive patients with hepatic hemangiomas, ultrasonography was performed to determine total tumor number, size, echogenicity and location, and serum laboratory tests for liver function and coagulation factors were carried out. The ultrasonographic appearance of hemangiomas was homogeneous in 75.7% of cases and mixed in 24.3% of cases. A mixed echo pattern was seen in 1 out of 145 masses (0.7%) with a diameter <20 mm, in 30 out of 48 (62.5%) with a diameter of 20‑40 mm, and in all of the 21 (100%) with a diameter >40 mm. Platelet counts (P<0.0001) and fibrinogen levels (P<0.01) were lower in patients with larger and mixed tumors. Levels of thrombin‑antithrombin III complex (TAT), D‑dimer, and fibrin and fibrinogen degradation products (FDP) were significantly elevated along with an increase in tumor size (all P<0.0001), and the number of patients with the abnormal values of TAT, D‑dimer, and FDP was significantly higher in the mixed group than in the homogeneous group (all P<0.0001). Fibrinogen (P<0.01), platelet count (P<0.001), portal vein diameter (P<0.0001), splenic index (P<0.01), and levels of TAT, D‑dimer and FDP (all P<0.0001) were significantly associated with tumor size. Multivariate analysis revealed TAT, D‑dimer and FDP as independent predictors of tumor size. The internal echo pattern became mixed as size increased. The size and echogenicity of hemangiomas were closely associated with coagulation factors. Therefore, it was speculated that differences in size and echogenicity were caused by intratumoral thrombosis and subsequent hemorrhage.
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Copy and paste a formatted citation
Spandidos Publications style
Maruyama S, Koda M, Matono T and Isomoto H: Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma. Mol Clin Oncol 14: 83, 2021.
APA
Maruyama, S., Koda, M., Matono, T., & Isomoto, H. (2021). Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma. Molecular and Clinical Oncology, 14, 83. https://doi.org/10.3892/mco.2021.2245
MLA
Maruyama, S., Koda, M., Matono, T., Isomoto, H."Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma". Molecular and Clinical Oncology 14.4 (2021): 83.
Chicago
Maruyama, S., Koda, M., Matono, T., Isomoto, H."Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma". Molecular and Clinical Oncology 14, no. 4 (2021): 83. https://doi.org/10.3892/mco.2021.2245
Copy and paste a formatted citation
x
Spandidos Publications style
Maruyama S, Koda M, Matono T and Isomoto H: Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma. Mol Clin Oncol 14: 83, 2021.
APA
Maruyama, S., Koda, M., Matono, T., & Isomoto, H. (2021). Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma. Molecular and Clinical Oncology, 14, 83. https://doi.org/10.3892/mco.2021.2245
MLA
Maruyama, S., Koda, M., Matono, T., Isomoto, H."Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma". Molecular and Clinical Oncology 14.4 (2021): 83.
Chicago
Maruyama, S., Koda, M., Matono, T., Isomoto, H."Association of tumor size and internal echo pattern with coagulopathy associated with hepatic hemangioma". Molecular and Clinical Oncology 14, no. 4 (2021): 83. https://doi.org/10.3892/mco.2021.2245
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