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Article

VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates

  • Authors:
    • Michalis Mazonakis
    • Stefanos Kachris
    • John Damilakis
  • View Affiliations / Copyright

    Affiliations: Department of Medical Physics, Faculty of Medicine, University of Crete, 71003 Iraklion, Greece, Department of Radiotherapy and Oncology, University Hospital of Iraklion, 71110 Iraklion, Greece
  • Article Number: 89
    |
    Published online on: March 5, 2021
       https://doi.org/10.3892/mco.2021.2251
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Abstract

The aim of the present study was to examine the effect of the photon beam energy on the volumetric modulated arc therapy (VMAT) plan quality for prostate cancer and on the risk of secondary carcinogenesis. Separate VMAT plans with 6‑MV and 10‑MV photons were created for 11 low‑risk patients with prostate cancer. The prescribed tumor dose was 70 Gy delivered in 28 fractions. The normal tissue integral dose and parameters associated with planning target volume and organs at risk were determined by the treatment planning data. A non‑linear mechanistic model considering the effects of tumor dose fractionation and cell proliferation was employed for estimating the patient‑specific lifetime attributable risk (LAR) for bladder and rectal cancer induction. Data from differential dose‑volume histograms were used for these risk assessments. The mean values of the planning parameters from 6‑MV treatment plans differed by 0.2‑3.4% from those associated with irradiation using 10‑MV photons. The LAR range for developing secondary bladder malignancies varied between 0.041 and 0.129% by the patient under investigation and the beam energy used. The corresponding range for the appearance of rectal malignant diseases was 0.047‑0.153%. The mean percentage difference between the bladder cancer risks from VMAT with 6‑MV and 10‑MV photons was 2.6±2.3%. The corresponding difference for secondary rectal malignancies was 0.7±0.6%. Therefore, VMAT for prostate cancer with both 6‑MV and 10‑MV photons leads to clinically equivalent treatment plans and to similar secondary bladder and rectal cancer risks.
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Copy and paste a formatted citation
Spandidos Publications style
Mazonakis M, Kachris S and Damilakis J: VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates. Mol Clin Oncol 14: 89, 2021.
APA
Mazonakis, M., Kachris, S., & Damilakis, J. (2021). VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates. Molecular and Clinical Oncology, 14, 89. https://doi.org/10.3892/mco.2021.2251
MLA
Mazonakis, M., Kachris, S., Damilakis, J."VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates". Molecular and Clinical Oncology 14.5 (2021): 89.
Chicago
Mazonakis, M., Kachris, S., Damilakis, J."VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates". Molecular and Clinical Oncology 14, no. 5 (2021): 89. https://doi.org/10.3892/mco.2021.2251
Copy and paste a formatted citation
x
Spandidos Publications style
Mazonakis M, Kachris S and Damilakis J: VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates. Mol Clin Oncol 14: 89, 2021.
APA
Mazonakis, M., Kachris, S., & Damilakis, J. (2021). VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates. Molecular and Clinical Oncology, 14, 89. https://doi.org/10.3892/mco.2021.2251
MLA
Mazonakis, M., Kachris, S., Damilakis, J."VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates". Molecular and Clinical Oncology 14.5 (2021): 89.
Chicago
Mazonakis, M., Kachris, S., Damilakis, J."VMAT for prostate cancer with 6‑MV and 10‑MV photons: Impact of beam energy on treatment plan quality and model‑based secondary cancer risk estimates". Molecular and Clinical Oncology 14, no. 5 (2021): 89. https://doi.org/10.3892/mco.2021.2251
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