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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2021 Volume 14 Issue 5

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Case Report

Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review

  • Authors:
    • Rintaro Okano
    • Kohei Suzuki
    • Yoshiteru Nakano
    • Junkoh Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807‑8555, Japan
  • Article Number: 95
    |
    Published online on: March 12, 2021
       https://doi.org/10.3892/mco.2021.2257
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Abstract

Primary central nervous system lymphoma (PCNSL) is a rare intracranial neoplasm in older adults. Tumor‑associated parkinsonism (TAP) in PCNSL is extremely rare, and its clinical features are unclear. The present report describes the case of a 75‑year‑old man who presented with parkinsonism due to multiple hyperintense lesions in the thalamus and periventricular white matter as visualized by magnetic resonance imaging (MRI). Due to the rapid progression of parkinsonism and lesion enlargement, the patient underwent stereotaxic biopsy. Subsequently, his condition was diagnosed as TAP in PCNSL at 2 months after onset. The patient completely recovered after treatment and experienced no recurrence of TAP for 8 months. Although it is difficult to distinguish TAP from vascular parkinsonism (VP) at initial consultation, the early diagnosis of PCNSL is important for improving prognosis. In the case of rapidly progressing parkinsonism, one should suspect the possibility of TAP associated with early‑stage PCNSL. Early treatment improves the chances of remission and decreases the possibility of recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Okano R, Suzuki K, Nakano Y and Yamamoto J: Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review. Mol Clin Oncol 14: 95, 2021.
APA
Okano, R., Suzuki, K., Nakano, Y., & Yamamoto, J. (2021). Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review. Molecular and Clinical Oncology, 14, 95. https://doi.org/10.3892/mco.2021.2257
MLA
Okano, R., Suzuki, K., Nakano, Y., Yamamoto, J."Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review". Molecular and Clinical Oncology 14.5 (2021): 95.
Chicago
Okano, R., Suzuki, K., Nakano, Y., Yamamoto, J."Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review". Molecular and Clinical Oncology 14, no. 5 (2021): 95. https://doi.org/10.3892/mco.2021.2257
Copy and paste a formatted citation
x
Spandidos Publications style
Okano R, Suzuki K, Nakano Y and Yamamoto J: Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review. Mol Clin Oncol 14: 95, 2021.
APA
Okano, R., Suzuki, K., Nakano, Y., & Yamamoto, J. (2021). Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review. Molecular and Clinical Oncology, 14, 95. https://doi.org/10.3892/mco.2021.2257
MLA
Okano, R., Suzuki, K., Nakano, Y., Yamamoto, J."Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review". Molecular and Clinical Oncology 14.5 (2021): 95.
Chicago
Okano, R., Suzuki, K., Nakano, Y., Yamamoto, J."Primary central nervous system lymphoma presenting with Parkinsonism as an initial manifestation: A case report and literature review". Molecular and Clinical Oncology 14, no. 5 (2021): 95. https://doi.org/10.3892/mco.2021.2257
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