Open Access

Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer

  • Authors:
    • Takuya Nagata
    • Masahiko Kanamori
    • Shinichi Sekine
    • Mie Arai
    • Makoto Moriyama
    • Tsutomu Fujii
  • View Affiliations

  • Published online on: March 17, 2021     https://doi.org/10.3892/mco.2021.2265
  • Article Number: 103
  • Copyright: © Nagata et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Modulated electro‑hyperthermia (mEHT) is a new treatment modality developed to overcome the problems associated with traditional hyperthermia; mEHT uses a precise impedance‑matched system and modulated radiofrequency current flow to malignant tumors. It selects the malignant cells based on their biophysical differences, due to their high metabolic rate, individual (autonomic) behavior and membrane status. The aim of the present study was to report the outcomes of mEHT in the treatment of advanced breast cancer. mEHT was examined in 10 patients with advanced metastatic breast cancer and recurrent disease, who were considered incurable by standard therapy protocols. Of the 10 patients, partial response was achieved in 3, disease stability in 3, and progressive disease in 4; however, their quality of life was improved based on their subjective reports. No adverse effects were observed in any of the 10 patients. The present study demonstrated the feasibility of mEHT as a possible therapy for advanced breast cancer cases when standard therapies fail. Moreover, mEHT had no side effects and may be combined with various treatments for long‑term therapy.
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May-2021
Volume 14 Issue 5

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Nagata T, Kanamori M, Sekine S, Arai M, Moriyama M and Fujii T: Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer. Mol Clin Oncol 14: 103, 2021.
APA
Nagata, T., Kanamori, M., Sekine, S., Arai, M., Moriyama, M., & Fujii, T. (2021). Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer. Molecular and Clinical Oncology, 14, 103. https://doi.org/10.3892/mco.2021.2265
MLA
Nagata, T., Kanamori, M., Sekine, S., Arai, M., Moriyama, M., Fujii, T."Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer". Molecular and Clinical Oncology 14.5 (2021): 103.
Chicago
Nagata, T., Kanamori, M., Sekine, S., Arai, M., Moriyama, M., Fujii, T."Clinical study of modulated electro‑hyperthermia for advanced metastatic breast cancer". Molecular and Clinical Oncology 14, no. 5 (2021): 103. https://doi.org/10.3892/mco.2021.2265