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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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June-2021 Volume 14 Issue 6

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Case Report Open Access

COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report

  • Authors:
    • Rinat Yerushalmi
    • Moshe Sagi
    • Hadar Goldvaser
    • Jonathan Daliot
    • Raz Mutai
    • Ilan Krause
  • View Affiliations / Copyright

    Affiliations: Institute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Petach Tikva 49100, Israel, Department of Internal Medicine F, Rabin Medical Center‑Beilinson Hospital, Petach Tikva 49100, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Copyright: © Yerushalmi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 117
    |
    Published online on: April 8, 2021
       https://doi.org/10.3892/mco.2021.2279
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Abstract

Patients receiving chemotherapy are at high risk for severe infections and complications such as acute respiratory syndrome. The most commonly used adjuvant chemotherapy protocols (docetaxel‑cyclophosphamide every 3 weeks or the dose‑dense regimen, doxorubicin‑cyclophosphamide every 2 weeks followed by paclitaxel) incorporate granulocyte‑colony stimulating factor (G‑CSF). G‑CSF is routinely administered to prevent chemotherapy‑associated neutropenia but often results in significant neutrophilia. The present case describes a patient with breast cancer who was successfully treated for severe COVID‑19 respiratory syndrome while under adjuvant chemotherapy (docetaxel‑cyclophosphamide) treatment and long‑term G‑CSF support. In addition, the potential effect of G‑CSF on the respiratory deterioration of the patient given its cardinal role in innate inflammation and, accordingly, the cytokine storm associated with COVID‑19 was described. The case described in the present study indicated how solutions to the immunity challenges faced when treating a patient with chemotherapy may be the source of a larger problem within the coronavirus COVID‑19 pandemic.
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Copy and paste a formatted citation
Spandidos Publications style
Yerushalmi R, Sagi M, Goldvaser H, Daliot J, Mutai R and Krause I: COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Mol Clin Oncol 14: 117, 2021.
APA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., & Krause, I. (2021). COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Molecular and Clinical Oncology, 14, 117. https://doi.org/10.3892/mco.2021.2279
MLA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14.6 (2021): 117.
Chicago
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14, no. 6 (2021): 117. https://doi.org/10.3892/mco.2021.2279
Copy and paste a formatted citation
x
Spandidos Publications style
Yerushalmi R, Sagi M, Goldvaser H, Daliot J, Mutai R and Krause I: COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Mol Clin Oncol 14: 117, 2021.
APA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., & Krause, I. (2021). COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Molecular and Clinical Oncology, 14, 117. https://doi.org/10.3892/mco.2021.2279
MLA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14.6 (2021): 117.
Chicago
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14, no. 6 (2021): 117. https://doi.org/10.3892/mco.2021.2279
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