Open Access

COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report

  • Authors:
    • Rinat Yerushalmi
    • Moshe Sagi
    • Hadar Goldvaser
    • Jonathan Daliot
    • Raz Mutai
    • Ilan Krause
  • View Affiliations

  • Published online on: April 8, 2021     https://doi.org/10.3892/mco.2021.2279
  • Article Number: 117
  • Copyright: © Yerushalmi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Patients receiving chemotherapy are at high risk for severe infections and complications such as acute respiratory syndrome. The most commonly used adjuvant chemotherapy protocols (docetaxel‑cyclophosphamide every 3 weeks or the dose‑dense regimen, doxorubicin‑cyclophosphamide every 2 weeks followed by paclitaxel) incorporate granulocyte‑colony stimulating factor (G‑CSF). G‑CSF is routinely administered to prevent chemotherapy‑associated neutropenia but often results in significant neutrophilia. The present case describes a patient with breast cancer who was successfully treated for severe COVID‑19 respiratory syndrome while under adjuvant chemotherapy (docetaxel‑cyclophosphamide) treatment and long‑term G‑CSF support. In addition, the potential effect of G‑CSF on the respiratory deterioration of the patient given its cardinal role in innate inflammation and, accordingly, the cytokine storm associated with COVID‑19 was described. The case described in the present study indicated how solutions to the immunity challenges faced when treating a patient with chemotherapy may be the source of a larger problem within the coronavirus COVID‑19 pandemic.
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June-2021
Volume 14 Issue 6

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Spandidos Publications style
Yerushalmi R, Sagi M, Goldvaser H, Daliot J, Mutai R and Krause I: COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Mol Clin Oncol 14: 117, 2021
APA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., & Krause, I. (2021). COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report. Molecular and Clinical Oncology, 14, 117. https://doi.org/10.3892/mco.2021.2279
MLA
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14.6 (2021): 117.
Chicago
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., Krause, I."COVID‑19 in a patient receiving adjuvant breast cancer chemotherapy with granulocyte olony‑stimulating factor (G‑CSF) support: A case report". Molecular and Clinical Oncology 14, no. 6 (2021): 117. https://doi.org/10.3892/mco.2021.2279