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Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma

  • Authors:
    • Taito Fukushima
    • Manabu Morimoto
    • Satoshi Kobayashi
    • Makoto Ueno
    • Yusuke Sano
    • Kuniyuki Kawano
    • Hiroyuki Asama
    • Shuhei Nagashima
    • Shin Maeda
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, Yokohama, Kanagawa 241‑8515, Japan, Department of Gastroenterology, Yokohama City University Hospital, Yokohama, Kanagawa 236-0004, Japan
    Copyright: © Fukushima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 119
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    Published online on: April 12, 2021
       https://doi.org/10.3892/mco.2021.2281
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Abstract

The aim of the present study was to evaluate the long‑term outcomes and the impact of repeated conventional transarterial chemoembolization (C‑TACE) and transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer embolics (SAP‑TACE) on liver function in TACE‑naïve patients with unresectable hepatocellular carcinoma (HCC). Overall, 155 consecutive patients with HCC received either C‑TACE or SAP‑TACE. The first cohort (n=71), treated between 2011 and 2014, received C‑TACE; the second cohort (n=84), treated between 2014 and 2016, received SAP‑TACE. Overall survival and deterioration of liver function were compared between the two cohorts. The 1‑, 2‑ and 3‑year overall survival rates and median survival times were 74, 50, 35% and 26 months in the C‑TACE cohort and 75, 60, 39% and 28 months in the SAP‑TACE cohort, respectively. There were no significant differences between the two groups (P=0.289). Age <70 years, Child‑Pugh class A, alpha‑fetoprotein <400 ng/ml and des‑gamma‑carboxy prothrombin <1,000 mAU/ml were identified as favorable prognostic factors in multivariate analysis. In the subgroup of patients with a Child‑Pugh score of 5, survival was 29 months for C‑TACE vs. 55 months for SAP‑TACE (P<0.05). In the C‑TACE cohort, the median Child‑Pugh score was 6 after 3 cycles and 7 after 5 cycles of TACE, and the score worsened significantly (before vs. 3 cycles, P<0.05; before vs. 5 cycles, P<0.05). In the SAP‑TACE cohort, the median Child‑Pugh score was 6 after 3 and 5 cycles of TACE, and the score did not worsen during the treatment cycles. There were no differences in overall survival between repeated C‑TACE and SAP‑TACE in TACE‑naïve patients with HCC. However, liver function deterioration was more evident in patients treated with C‑TACE than in those treated with SAP‑TACE.
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1 

Forner A, Reig M and Bruix J: Hepatocellular carcinoma. Lancet. 391:1301–1314. 2018.PubMed/NCBI View Article : Google Scholar

2 

Vauthey JN, Dixon E, Abdalla EK, Helton WS, Pawlik TM, Taouli B, Brouquet A and Adams RB: American Hepato-Pancreato-Biliary Association; Society of Surgical Oncology; Society for Surgery of the Alimentary Tract. Pretreatment assessment of hepatocellular carcinoma: Expert consensus statement. HPB (Oxford). 12:289–299. 2010.PubMed/NCBI View Article : Google Scholar

3 

European Association for the Study of the Liver. Electronic address: simpleeasloffice@easloffice.eu; European Association for the Study of the Liver. EASL clinical practice guidelines: Management of hepatocellular carcinoma. J Hepatol. 69:182–236. 2018.PubMed/NCBI View Article : Google Scholar

4 

Heimbach JK, Kulik LM, Finn RS, Sirlin CB, Abecassis MM, Roberts LR, Zhu AX, Murad MH and Marrero JA: AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 67:358–380. 2018.PubMed/NCBI View Article : Google Scholar

5 

Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, Tateishi R, Han KH, Chawla YK, Shiina S, et al: Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: A 2017 update. Hepatol Int. 11:317–370. 2017.PubMed/NCBI View Article : Google Scholar

6 

Facciorusso A, Serviddio G and Muscatiello N: Transarterial radioembolization vs. chemoembolization for hepatocarcinoma patients: A systematic review and meta-analysis. World J Hepatol. 8:770–778. 2016.PubMed/NCBI View Article : Google Scholar

7 

Facciorusso A, Di Maso M and Muscatiello N: Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma: A meta-analysis. Dig Liver Dis. 48:571–577. 2016.PubMed/NCBI View Article : Google Scholar

8 

Facciorusso A, Mariani L, Sposito C, Spreafico C, Bongini M, Morosi C, Cascella T, Marchianò A, Camerini T, Bhoori S, et al: Drug-eluting beads versus conventional chemoembolization for the treatment of unresectable hepatocellular carcinoma. J Gastroenterol Hepatol. 31:645–653. 2016.PubMed/NCBI View Article : Google Scholar

9 

Golfieri R, Giampalma E, Renzulli M, Cioni R, Bargellini I, Bartolozzi C, Breatta AD, Gandini G, Nani R, Gasparini D, et al: Randomised controlled trial of doxorubicin-eluting beads vs. conventional chemoembolisation for hepatocellular carcinoma. Br J Cancer. 111:255–264. 2014.PubMed/NCBI View Article : Google Scholar

10 

Osuga K, Khankan AA, Hori S, Okada A, Sugiura T, Maeda M, Nagano H, Yamada A, Murakami T and Nakamura H: Transarterial embolization for large hepatocellular carcinoma with use of superabsorbent polymer microspheres: Initial experience. J Vasc Interv Radiol. 13:929–934. 2002.PubMed/NCBI View Article : Google Scholar

11 

Grosso M, Vignali C, Quaretti P, Nicolini A, Melchiorre F, Gallarato G, Bargellini I, Petruzzi P, Massa Saluzzo C, Crespi S and Sarti I: Transarterial chemoembolization for hepatocellular carcinoma with drug-eluting microspheres: Preliminary results from an Italian multicentre study. Cardiovasc Intervent Radiol. 31:1141–1149. 2008.PubMed/NCBI View Article : Google Scholar

12 

Seki A, Hori S, Kobayashi K and Narumiya S: Transcatheter arterial chemoembolization with epirubicin-loaded superabsorbent polymer microspheres for 135 hepatocellular carcinoma patients: Single-center experience. Cardiovasc Intervent Radiol. 34:557–565. 2011.PubMed/NCBI View Article : Google Scholar

13 

van Malenstein H, Maleux G, Vandecaveye V, Heye S, Laleman W, van Pelt J, Vaninbroukx J, Nevens F and Verslype C: A randomized phase II study of drug-eluting beads versus transarterial chemoembolization for unresectable hepatocellular carcinoma. Onkologie. 34:368–376. 2011.PubMed/NCBI View Article : Google Scholar

14 

Duan F, Wang EQ, Lam MG, Abdelmaksoud MH, Louie JD, Hwang GL, Kothary N, Kuo WT, Hofmann LV and Sze DY: Superselective chemoembolization of HCC: Comparison of short-term safety and efficacy between drug-eluting LC beads, quadraspheres, and conventional ethiodized oil emulsion. Radiology. 278:612–621. 2016.PubMed/NCBI View Article : Google Scholar

15 

Kucukay F, Badem S, Karan A, Ozdemir M, Okten RS, Ozbulbul NI, Kucukay MB, Unlu I, Bostanci EB and Akdogan M: A single-center retrospective comparison of doxorubicin-loaded hepasphere transarterial chemoembolization with conventional transarterial chemoembolization for patients with unresectable hepatocellular carcinoma. J Vasc Interv Radiol. 26:1622–1629. 2015.PubMed/NCBI View Article : Google Scholar

16 

Morimoto M, Kobayashi S, Moriya S, Ueno M, Tezuka S, Irie K, Goda Y and Ohkawa S: Short-term efficacy of transarterial chemoembolization with epirubicin-loaded superabsorbent polymer microspheres for hepatocellular carcinoma: Comparison with conventional transarterial chemoembolization. Abdom Radiol (NY). 42:612–619. 2017.PubMed/NCBI View Article : Google Scholar

17 

Facciorusso A: Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: Current state of the art. World J Gastroenterol. 24:161–169. 2018.PubMed/NCBI View Article : Google Scholar

18 

Bruix J, Qin S, Merle P, Granito A, Huang YH, Bodoky G, Pracht M, Yokosuka O, Rosmorduc O, Breder V, et al: Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 389:56–66. 2017.PubMed/NCBI View Article : Google Scholar

19 

Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, et al: Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: A randomised phase 3 non-inferiority trial. Lancet. 391:1163–1173. 2018.PubMed/NCBI View Article : Google Scholar

20 

Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, et al: Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 359:378–390. 2008.PubMed/NCBI View Article : Google Scholar

21 

Hiraoka A, Kumada T, Kudo M, Hirooka M, Koizumi Y, Hiasa Y, Tajiri K, Toyoda H, Tada T, Ochi H, et al: Hepatic function during repeated TACE procedures and prognosis after introducing sorafenib in patients with unresectable hepatocellular carcinoma: Multicenter analysis. Dig Dis. 35:602–610. 2017.PubMed/NCBI View Article : Google Scholar

22 

Miksad RA, Ogasawara S, Xia F, Fellous M and Piscaglia F: Liver function changes after transarterial chemoembolization in US hepatocellular carcinoma patients: The LiverT study. BMC Cancer. 19(795)2019.PubMed/NCBI View Article : Google Scholar

23 

Lencioni R, de Baere T, Burrel M, Caridi JG, Lammer J, Malagari K, Martin RC, O'Grady E, Real MI, Vogl TJ, et al: Transcatheter treatment of hepatocellular carcinoma with doxorubicin-loaded DC Bead (DEBDOX): Technical recommendations. Cardiovasc Intervent Radiol. 35:980–985. 2012.PubMed/NCBI View Article : Google Scholar

24 

Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, et al: Assessment of liver function in patients with hepatocellular carcinoma: A new evidence-based approach-the ALBI grade. J Clin Oncol. 33:550–558. 2015.PubMed/NCBI View Article : Google Scholar

25 

Idee JM and Guiu B: Use of Lipiodol as a drug-delivery system for transcatheter arterial chemoembolization of hepatocellular carcinoma: A review. Crit Rev Oncol Hematol. 88:530–549. 2013.PubMed/NCBI View Article : Google Scholar

26 

Pinato DJ, Yen C, Bettinger D, Ramaswami R, Arizumi T, Ward C, Pirisi M, Burlone ME, Thimme R, Kudo M and Sharma R: The albumin-bilirubin grade improves hepatic reserve estimation post-sorafenib failure: Implications for drug development. Aliment Pharmacol Ther. 45:714–722. 2017.PubMed/NCBI View Article : Google Scholar

27 

Ueshima K, Nishida N, Hagiwara S, Aoki T, Minami T, Chishina H, Takita M, Minami Y, Ida H, Takenaka M, et al: Impact of baseline ALBI grade on the outcomes of hepatocellular carcinoma patients treated with lenvatinib: A multicenter study. Cancers (Basel). 11(952)2019.PubMed/NCBI View Article : Google Scholar

28 

El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH Rd, et al: Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): An open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 389:2492–2502. 2017.PubMed/NCBI View Article : Google Scholar

29 

Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, et al: Cabozantinib in patients with advanced and progressing hepatocellular carcinoma. N Engl J Med. 379:54–63. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, Palmer D, Verslype C, Zagonel V, Fartoux L, Vogel A, et al: Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): A non-randomised, open-label phase 2 trial. Lancet Oncol. 19:940–952. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Fukushima T, Morimoto M, Kobayashi S, Ueno M, Sano Y, Kawano K, Asama H, Nagashima S and Maeda S: Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma. Mol Clin Oncol 14: 119, 2021.
APA
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K. ... Maeda, S. (2021). Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma. Molecular and Clinical Oncology, 14, 119. https://doi.org/10.3892/mco.2021.2281
MLA
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K., Asama, H., Nagashima, S., Maeda, S."Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma". Molecular and Clinical Oncology 14.6 (2021): 119.
Chicago
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K., Asama, H., Nagashima, S., Maeda, S."Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma". Molecular and Clinical Oncology 14, no. 6 (2021): 119. https://doi.org/10.3892/mco.2021.2281
Copy and paste a formatted citation
x
Spandidos Publications style
Fukushima T, Morimoto M, Kobayashi S, Ueno M, Sano Y, Kawano K, Asama H, Nagashima S and Maeda S: Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma. Mol Clin Oncol 14: 119, 2021.
APA
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K. ... Maeda, S. (2021). Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma. Molecular and Clinical Oncology, 14, 119. https://doi.org/10.3892/mco.2021.2281
MLA
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K., Asama, H., Nagashima, S., Maeda, S."Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma". Molecular and Clinical Oncology 14.6 (2021): 119.
Chicago
Fukushima, T., Morimoto, M., Kobayashi, S., Ueno, M., Sano, Y., Kawano, K., Asama, H., Nagashima, S., Maeda, S."Repeated transarterial chemoembolization with epirubicin‑loaded superabsorbent polymer microspheres vs. conventional transarterial chemoembolization for hepatocellular carcinoma". Molecular and Clinical Oncology 14, no. 6 (2021): 119. https://doi.org/10.3892/mco.2021.2281
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