A preliminary study identifies early postoperative lung volume changes in patients with non‑small cell lung cancer following video‑assisted thoracic surgery using CT volumetry

Du,Xiaojun; Li,Haojun; Liu,Langbo; Zhang,Min; Tang,Zhongben; Zhang,Jian; Lin,Peng; Xie,Hong; Chen,Cheng

doi:10.3892/mco.2021.2286

A preliminary study identifies early postoperative lung volume changes in patients with non‑small cell lung cancer following video‑assisted thoracic surgery using CT volumetry

Authors:
- Xiaojun Du
- Haojun Li
- Langbo Liu
- Min Zhang
- Zhongben Tang
- Jian Zhang
- Peng Lin
- Hong Xie
- Cheng Chen
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Affiliations: Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Radiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563099, P.R. China
Published online on: April 22, 2021 https://doi.org/10.3892/mco.2021.2286
Article Number: 124
Copyright: © Du et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the changes in early postoperative lung volume in patients with non‑small cell lung cancer (NSCLC) following video‑assisted thoracic surgery (VATS) and to analyze the effects of the clinical characteristics on the lung volume of the patients. Therefore, 38 patients with NSCLC, who planned to undergo VATS at the Department of Thoracic Surgery, The Affiliated Hospital of Guizhou Medical University in June 2019, were enrolled into the present study. The clinical and computed tomography (CT) scan data from the patients was prospectively collected within 1 week preoperatively, and at 1, 3 and 6 months following surgery, then subsequently analyzed. A total of 34 patients successfully completed follow‑up and were included in the datasets. The results showed that the volume of the right lung was larger compared with that in the left one, at each observational time point. The whole, right and left lung held the same trendline of volume changes, which was sharply decreased during the first postoperative month, increased quickly over the next 3 months, and slowly increased from months 3 to 6. There were 7 patients, whose whole lung volume was increased at 6 months following surgery compared with that preoperatively. In addition, significant differences were observed between males and females in the whole, right and left lung volume. However, the differences on the postoperative net expansion volume of the whole lung were not significant among sex, age, body mass index (BMI), smoking status and surgical side subgroups. The early changes of the postoperative lung volume were not linear, since the lung volume was significantly reduced during the first postoperative month, quickly increased in the next 3 months, and slowly increased from months 3 to 6. Sex, age, BMI, smoking status and surgical sides was not found to affect the postoperative volume and net expansion of the whole lung following VATS lobectomy.

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1	Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019.PubMed/NCBI View Article : Google Scholar
2	Selzer A and Sarkiss M: Preoperative pulmonary evaluation. Med Clin North Am. 103:585–599. 2019.PubMed/NCBI View Article : Google Scholar
3	Lee H, Kim HK, Kang D, Kong S, Lee JK, Lee G, Shin S, Cho J, Zo JI, Shim YM and Park HY: Prognostic value of 6-Min walk test to predict postoperative cardiopulmonary complications in patients with non-small cell lung cancer. Chest. 157:1665–1673. 2020.PubMed/NCBI View Article : Google Scholar
4	Lakshminarasimhachar A and Smetana GW: Preoperative evaluation: Estimation of pulmonary risk. Anesthesiol Clin. 34:71–88. 2016.PubMed/NCBI View Article : Google Scholar
5	Ferguson MK, Watson S, Johnson E and Vigneswaran WT: Predicted postoperative lung function is associated with all-cause long-term mortality after major lung resection for cancer. Eur J Cardiothorac Surg. 45:660–664. 2014.PubMed/NCBI View Article : Google Scholar
6	Juhl B and Frost N: A comparison between measured and calculated changes in the lung function after operation for pulmonary cancer. Acta Anaesthesiol Scand Suppl. 57:39–45. 1975.PubMed/NCBI View Article : Google Scholar
7	Egeblad K, Aunsholt NA, Funder V and Nielsen PH: A simple method for predicting pulmonary function after lung resection. Scand J Thorac Cardiovasc Surg. 20:103–107. 1986.PubMed/NCBI View Article : Google Scholar
8	Nakahara K, Monden Y, Ohno K, Miyoshi S, Maeda H and Kawashima Y: A method for predicting postoperative lung function and its relation to postoperative complications in patients with lung cancer. Ann Thorac Surg. 39:260–265. 1985.PubMed/NCBI View Article : Google Scholar
9	Ontiveros N, Eapen-John D, Song J, Li L, Sheshadri A, Tian X, Ghosh N, Vaporciyan AA, Correa M, Walsh G, et al: Predicting postoperative lung function following lobectomy. Chest. 152(A640)2017.
10	Varela G, Brunelli A, Rocco G, Marasco R, Jiménez MF, Sciarra V, Aranda JL and Gatani T: Predicted versus observed FEV1 in the immediate postoperative period after pulmonary lobectomy. Eur J Cardiothorac Surg. 30:644–648. 2006.PubMed/NCBI View Article : Google Scholar
11	Brunelli A, Refai M, Salati M, Xiumé F and Sabbatini A: Predicted versus observed FEV1 and DLCO after major lung resection: A prospective evaluation at different postoperative periods. Ann Thorac Surg. 83:1134–1139. 2007.PubMed/NCBI View Article : Google Scholar
12	Bremer JL: The fate of the remaining lung tissue after lobectomy or pneumonectomy. J Thorac Surg. 6:336–343. 1937.
13	Wakamatsu I, Matsuguma H, Nakahara R and Chida M: Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: An analysis of lung weight and lung volume changes based on computed tomography findings. Surg Today. 50:144–152. 2020.PubMed/NCBI View Article : Google Scholar
14	Vinogradskiy Y, Jackson M, Schubert L, Jones B, Castillo R, Castillo E, Guerrero T, Mitchell J, Rusthoven C, Miften M and Kavanagh B: Assessing the use of 4DCT-ventilation in pre-operative surgical lung cancer evaluation. Med Phys. 44:200–208. 2017.PubMed/NCBI View Article : Google Scholar
15	Suzuki H, Oishi H, Noda M, Watanabe T, Matsuda Y, Tominaga J, Sado T, Sakurada A, Kurosawa H, Takase K and Okada Y: Correlation between the native lung volume change and postoperative pulmonary function after single lung transplantation for lymphangioleiomyomatosis: Evaluation of lung volume by three-dimensional computed tomography volumetry. PLoS One. 14(e0210975)2019.PubMed/NCBI View Article : Google Scholar
16	Gu S, Leader J, Zheng B, Chen Q, Sciurba F, Kminski N, Gur D and Pu J: Direct assessment of lung function in COPD using CT densitometric measures. Physiol Meas. 35:833–845. 2014.PubMed/NCBI View Article : Google Scholar
17	Choe J, Lee SM, Chae EJ, Kim YH, Kim N and Seo JB: Evaluation of postoperative lung volume and perfusion changes by dual-energy computed tomography in patients with lung cancer. Eur J Radiol. 90:166–173. 2017.PubMed/NCBI View Article : Google Scholar
18	Fourdrain A, De Dominicis F, Lafitte S, Iquille J, Prevot F, Lorne E, Monconduit J, Bagan P and Berna P: Quantitative computed tomography to predict postoperative FEV1 after lung cancer surgery. J Thorac Dis. 9:2413–2418. 2017.PubMed/NCBI View Article : Google Scholar
19	Kobayashi K, Saeki Y, Kitazawa S, Kobayashi N, Kikuchi S, Goto Y, Sakai M and Sato Y: Three-dimensional computed tomographic volumetry precisely predicts the postoperative pulmonary function. Surg Today. 47:1303–1311. 2017.PubMed/NCBI View Article : Google Scholar
20	Oswald NK, Halle-Smith J, Mehdi R, Nightingale P, Naidu B and Turner AM: Predicting postoperative lung function following lung cancer resection: A systematic review and meta-analysis. EClinicalMedicine. 15:7–13. 2019.PubMed/NCBI View Article : Google Scholar
21	Sihoe ADL: The evolution of minimally invasive thoracic surgery: Implications for the practice of uniportal thoracoscopic surgery. J Thorac Dis. 6 (Suppl 6):S604–S617. 2014.PubMed/NCBI View Article : Google Scholar
22	Nagamatsu Y, Maeshiro K, Kimura NY, Nishi T, Shima I, Yamana H and Shirouzu K: Long-term recovery of exercise capacity and pulmonary function after lobectomy. J Thorac Cardiovasc Surg. 134:1273–1278. 2007.PubMed/NCBI View Article : Google Scholar
23	Kim HK, Lee YJ, Han KN and Choi YH: Pulmonary function changes over 1 year after lobectomy in lung cancer. Respir Care. 61:376–382. 2016.PubMed/NCBI View Article : Google Scholar
24	Yokoba M, Ichikawa T, Harada S, Naito M, Sato Y and Katagiri M: Postoperative pulmonary function changes according to the resected lobe: A 1-year follow-up study of lobectomized patients. J Thorac Dis. 10:6891–6902. 2018.PubMed/NCBI View Article : Google Scholar
25	Kim SJ, Lee YJ, Park JS, Cho YJ, Cho S, Yoon HI, Kim K, Lee JH, Jheon S and Lee CT: Changes in pulmonary function in lung cancer patients after video-assisted thoracic surgery. Ann Thorac Surg. 99:210–217. 2015.PubMed/NCBI View Article : Google Scholar
26	Ueda K, Tanaka T, Hayashi M, Li TS, Tanaka N and Hamano K: Computed tomography-defined functional lung volume after segmentectomy versus lobectomy. Eur J Cardiothorac Surg. 37:1433–1437. 2010.PubMed/NCBI View Article : Google Scholar
27	Khieya T: An Evaluation of the pulmonary function tests and their association with age and body mass index (BMI) in the southern angami population. J North East Indian Cult. 3:82–91. 2017.
28	Kim SJ, Ahn S, Lee YJ, Park JS, Cho YJ, Cho S, Yoon HI, Kim K, Lee JH, Jheon S and Lee CT: Factors associated with preserved pulmonary function in non-small-cell lung cancer patients after video-assisted thoracic surgery. Eur J Cardiothorac Surg. 49:1084–1090. 2016.PubMed/NCBI View Article : Google Scholar
29	Takahashi Y, Matsutani N, Morita S, Dejima H, Nakayama T, Uehara H and Kawamura M: Predictors of long-term compensatory response of pulmonary function following major lung resection for non-small cell lung cancer: Long-term lung function after lobectomy. Respirology. 22:364–371. 2017.PubMed/NCBI View Article : Google Scholar
30	Smetana GW: Preoperative pulmonary evaluation. N Engl J Med. 340:937–944. 1999.PubMed/NCBI View Article : Google Scholar
31	Matsumoto R, Takamori S, Yokoyama S, Hashiguchi T, Murakami D, Yoshiyama K, Nishi T, Kashihara M, Mitsuoka M, Hayashida R, et al: Lung function in the late postoperative phase and influencing factors in patients undergoing pulmonary lobectomy. J Thorac Dis. 10:2916–2923. 2018.PubMed/NCBI View Article : Google Scholar
32	Kobayashi N, Kobayashi K, Kikuchi S, Goto Y, Ichimura H, Endo K and Sato Y: Long-term pulmonary function after surgery for lung cancer. Interact Cardiovasc Thorac Surg. 24:727–732. 2017.PubMed/NCBI View Article : Google Scholar
33	Behera A, Behera BK, Dash S and Mishra S: Variation of pulmonary function tests with relation to increasing age in healthy adults. Int J Health Sci Res. 4:136–141. 2014.
34	Britto RR, Zampa CC, Oliveira TA, de Oliveira TA, Prado LF and Parreira VF: Effects of the aging process on respiratory function. Gerontology. 55:505–510. 2009.PubMed/NCBI View Article : Google Scholar