Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai

Xie,Li; Li,Qian; Dong,Xiangrong; Kong,Qi; Duan,Yuping; Chen,Xiong; Li,Xiaoqiang; Hong,Mao; Liu,Tao

doi:10.3892/mco.2021.2294

Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai

Authors:
- Li Xie
- Qian Li
- Xiangrong Dong
- Qi Kong
- Yuping Duan
- Xiong Chen
- Xiaoqiang Li
- Mao Hong
- Tao Liu
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Affiliations: Clinical Laboratory, Zhongshan Hospital Affiliated to Fudan University Wusong Hospital, Shanghai 200940, P.R. China, Ear, Nose and Throat Department, Shanghai Gongli Hospital, Shanghai 200940, P.R. China, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510641, P.R. China
Published online on: May 9, 2021 https://doi.org/10.3892/mco.2021.2294
Article Number: 132
Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cervical cancer, one of the high‑incidence female malignant tumors, has predominated in recent years. Persistent infection with high‑risk human papillomavirus (HR‑HPV) is the main cause of cervical cancer. Studies have shown that infection with certain sexually transmitted disease (STD) pathogens increases the risk of persistent infection with HR‑HPV and is a high‑risk factor for cervical cancer. In the present study, cervical specimens were collected for Thinprep cytology test detection, while DNA of cervical cells was extracted for HPV genotyping and detection of 10 STD pathogens, including Neisseria gonorrhoeae, Chlamydia trachomatis (CT), Ureaplasma urealyticum, Ureaplasma urealyticum parvum (Uup)1, Uup3, Uup6, Uup14, Mycoplasma hominis (Mh), Mycoplasma genitalium (Mg) and herpes simplex virus II. Significant differences were observed between CT, Mh and Mg infections and HR‑HPV infection (P<0.05). In addition, CT, Uup3, Uup6 and Mh infections were associated with HR‑HPV infection (odds ratio >1; P<0.05). In the comparison of Uup3, Uup6 and Mg infections between the cervical intraepithelial neoplasia (CIN) group and the control group, statistically significant differences were observed (P<0.05). In conclusion, the incidences of CT, Mh and Mg infections were similar with HR‑HPV infection. CT, Uup6, Mh and Mg infections were risk factors for HR‑HPV infection. Finally, Uup3, Uup6 and Mg were risk factors of CIN.

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