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Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai

  • Authors:
    • Li Xie
    • Qian Li
    • Xiangrong Dong
    • Qi Kong
    • Yuping Duan
    • Xiong Chen
    • Xiaoqiang Li
    • Mao Hong
    • Tao Liu
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, Zhongshan Hospital Affiliated to Fudan University Wusong Hospital, Shanghai 200940, P.R. China, Ear, Nose and Throat Department, Shanghai Gongli Hospital, Shanghai 200940, P.R. China, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510641, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 132
    |
    Published online on: May 9, 2021
       https://doi.org/10.3892/mco.2021.2294
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Abstract

Cervical cancer, one of the high‑incidence female malignant tumors, has predominated in recent years. Persistent infection with high‑risk human papillomavirus (HR‑HPV) is the main cause of cervical cancer. Studies have shown that infection with certain sexually transmitted disease (STD) pathogens increases the risk of persistent infection with HR‑HPV and is a high‑risk factor for cervical cancer. In the present study, cervical specimens were collected for Thinprep cytology test detection, while DNA of cervical cells was extracted for HPV genotyping and detection of 10 STD pathogens, including Neisseria gonorrhoeae, Chlamydia trachomatis (CT), Ureaplasma urealyticum, Ureaplasma urealyticum parvum (Uup)1, Uup3, Uup6, Uup14, Mycoplasma hominis (Mh), Mycoplasma genitalium (Mg) and herpes simplex virus II. Significant differences were observed between CT, Mh and Mg infections and HR‑HPV infection (P<0.05). In addition, CT, Uup3, Uup6 and Mh infections were associated with HR‑HPV infection (odds ratio >1; P<0.05). In the comparison of Uup3, Uup6 and Mg infections between the cervical intraepithelial neoplasia (CIN) group and the control group, statistically significant differences were observed (P<0.05). In conclusion, the incidences of CT, Mh and Mg infections were similar with HR‑HPV infection. CT, Uup6, Mh and Mg infections were risk factors for HR‑HPV infection. Finally, Uup3, Uup6 and Mg were risk factors of CIN.
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1 

Venkatas J and Singh M: Cervical cancer: A meta-analysis, therapy and future of nanomedicine. Ecancermedicalscience. 14(1111)2020.PubMed/NCBI View Article : Google Scholar

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018.PubMed/NCBI View Article : Google Scholar

3 

Zhang J, Cheng K and Wang Z: Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: A meta-analysis. Arch Gynecol Obstet. 302:1329–1337. 2020.PubMed/NCBI View Article : Google Scholar

4 

Chesson HW, Meites E, Ekwueme DU, Saraiya M and Markowitz LE: Updated medical care cost estimates for HPV-associated cancers: Implications for cost-effectiveness analyses of HPV vaccination in the United States. Hum Vaccin Immunother. 15:1942–1948. 2019.PubMed/NCBI View Article : Google Scholar

5 

Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, Stremlau A and zur Hausen H: Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature. 314:111–114. 1985.PubMed/NCBI View Article : Google Scholar

6 

Galliverti G, Wullschleger S, Tichet M, Murugan D, Zangger N, Horton W, Korman AJ, Coussens LM, Swartz MA and Hanahan D: Myeloid cells orchestrate systemic immunosuppression, impairing the efficacy of immunotherapy against HPV+ cancers. Cancer Immunol Res. 8:131–145. 2020.PubMed/NCBI View Article : Google Scholar

7 

Hajia M and Sohrabi A: Possible synergistic interactions among multiple HPV genotypes in women suffering from genital neoplasia. Asian Pac J Cancer Prev. 19:785–789. 2018.PubMed/NCBI View Article : Google Scholar

8 

Looker KJ, Rönn MM, Brock PM, Brisson M, Drolet M, Mayaud P and Boily MC: Evidence of synergistic relationships between HIV and human papillomavirus (HPV): Systematic reviews and meta-analyses of longitudinal studies of HPV acquisition and clearance by HIV status, and of HIV acquisition by HPV status. J Int AIDS Soc. 21(e25110)2018.PubMed/NCBI View Article : Google Scholar

9 

Senba M and Mori N: Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection. Oncol Rev. 6(e17)2012.PubMed/NCBI View Article : Google Scholar

10 

Liang Y, Chen M, Qin L, Wan B and Wang H: A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia. Infect Agent Cancer. 14(29)2019.PubMed/NCBI View Article : Google Scholar

11 

Kamminga T, Koehorst JJ, Vermeij P, Slagman SJ, Martins Dos Santos VA, Bijlsma JJ and Schaap PJ: Persistence of functional protein domains in mycoplasma species and their role in host specificity and synthetic minimal life. Front Cell Infect Microbiol. 7(31)2017.PubMed/NCBI View Article : Google Scholar

12 

Schnee C, Schulsse S, Hotzel H, Ayling RD, Nicholas RA, Schubert E, Heller M, Ehricht R and Sachse K: A novel rapid DNA microarray assay enables identification of 37 mycoplasma species and highlights multiple mycoplasma infections. PLoS One. 7(e33237)2012.PubMed/NCBI View Article : Google Scholar

13 

Nelson S, Matlow A, Johnson G, Th'ng C, Dunn M and Quinn P: Detection of Ureaplasma urealyticum in endotracheal tube aspirates from neonates by PCR. J Clin Microbiol. 36:1236–1239. 1998.PubMed/NCBI View Article : Google Scholar

14 

Grattard F, Pozzetto B, de Barbeyrac B, Renaudin H, Clerc M, Gaudin OG and Bébéar C: Arbitrarily-primed PCR confirms the differentiation of strains of Ureaplasma urealyticum into two biovars. Mol Cell Probes. 9:383–389. 1995.PubMed/NCBI View Article : Google Scholar

15 

Kong F, Zhu X, Wang W, Zhou X, Gordon S and Gilbert GL: Comparative analysis and serovar-specific identification of multiple-banded antigen genes of Ureaplasma urealyticum biovar 1. J Clin Microbiol. 37:538–543. 1999.PubMed/NCBI View Article : Google Scholar

16 

Ruifu Y, Minli Z, Guo Z and Wang X: Biovar diversity is reflected by variations of genes encoding urease of Ureaplasma urealyticum. Microbiol Immunol. 41:625–627. 1997.PubMed/NCBI View Article : Google Scholar

17 

Deguchi T, Yasuda M and Maeda S: Non-chlamydial non-gonococcal urethritis. Nihon Rinsho. 67:167–171. 2009.PubMed/NCBI(In Japanese).

18 

Worboys M: In The Hidden Affliction: Sexually Transmitted Infections and Infertility in History. Szreter S (ed). University of Rochester Press, Rochester, NY, 2019.

19 

Kit S, Hazen M, Otsuka H, Qavi H, Trkula D and Dubbs DR: The site of integration of the herpes simplex virus type 1 thymidine kinase gene in human cells transformed by an HSV-1 DNA fragment. Int J Cancer. 28:767–776. 1981.PubMed/NCBI View Article : Google Scholar

20 

Horner P, Donders G, Cusini M, Gomberg M, Jensen JS and Unemo M: Should we be testing for urogenital Mycoplasma hominis, Ureaplasma parvum and Ureaplasma urealyticum in men and women?-a position statement from the European STI Guidelines Editorial Board. J Eur Acad Dermatol Venereol. 32:1845–1851. 2018.PubMed/NCBI View Article : Google Scholar

21 

Hlatshwayo M, Reno HEL and Yarbrough ML: STI update: Testing, treatment, and emerging threats. Cleve Clin J Med. 86:733–740. 2019.PubMed/NCBI View Article : Google Scholar

22 

Oh HY, Kim BS, Seo SS, Kong JS, Lee JK, Park SY, Hong KM, Kim HK and Kim MK: The association of uterine cervical microbiota with an increased risk for cervical intraepithelial neoplasia in Korea. Clin Microbiol Infect. 21:674.e1–9. 2015.PubMed/NCBI View Article : Google Scholar

23 

Hakama M, Luostarinen T, Hallmans G, Jellum E, Koskela P, Lehtinen M, Thoresen S, Youngman L and Hakulinen T: Joint effect of HPV16 with Chlamydia trachomatis and smoking on risk of cervical cancer: Antagonism or misclassification (Nordic countries). Cancer Causes Control. 11:783–790. 2000.PubMed/NCBI View Article : Google Scholar

24 

Kletzel HH, Rotem R, Barg M, Michaeli J and Reichman O: Ureaplasma urealyticum: The role as a pathogen in women's health, a systematic review. Curr Infect Dis Rep. 20(33)2018.PubMed/NCBI View Article : Google Scholar

25 

Wang L, Zhu L, Li H, Ma N, Huang H, Zhang X, Li Y and Fang J: Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions. J Int Med Res. 47:5548–5559. 2019.PubMed/NCBI View Article : Google Scholar

26 

Verteramo R, Pierangeli A, Mancini E, Calzolari E, Bucci M, Osborn J, Nicosia R, Chiarini F, Antonelli G and Degener AM: Human Papillomaviruses and genital co-infections in gynaecological outpatients. BMC Infect Dis. 9(16)2009.PubMed/NCBI View Article : Google Scholar

27 

Lukic A, Canzio C, Patella A, Giovagnoli M, Cipriani P, Frega A and Moscarini M: Determination of cervicovaginal microorganisms in women with abnormal cervical cytology: The role of ureaplasma urealyticum. Anticancer Res. 26:4843–4849. 2006.PubMed/NCBI

28 

Biernat-Sudolska M, Szostek S, Rojek-Zakrzewska D, Klimek M and Kosz-Vnenchak M: Concomitant infections with human papillomavirus and various mycoplasma and ureaplasma species in women with abnormal cervical cytology. Adv Med Sci. 56:299–303. 2011.PubMed/NCBI View Article : Google Scholar

29 

Smith JS, Herrero R, Bosetti C, Muñoz N, Bosch FX, Eluf-Neto J, Castellsagué X, Meijer CJ, Van den Brule AJ, Franceschi S, et al: Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst. 94:1604–1613. 2002.PubMed/NCBI View Article : Google Scholar

30 

Li L, Zhu Q and Zheng S: Detection of human papillomavirus and herpesvirus genotypes in biopsy specimens from cervical carcinoma by PCR-endonuclease cleavage. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 13:235–238. 1999.PubMed/NCBI(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Xie L, Li Q, Dong X, Kong Q, Duan Y, Chen X, Li X, Hong M and Liu T: Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai. Mol Clin Oncol 15: 132, 2021.
APA
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X. ... Liu, T. (2021). Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai. Molecular and Clinical Oncology, 15, 132. https://doi.org/10.3892/mco.2021.2294
MLA
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X., Li, X., Hong, M., Liu, T."Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai". Molecular and Clinical Oncology 15.1 (2021): 132.
Chicago
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X., Li, X., Hong, M., Liu, T."Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai". Molecular and Clinical Oncology 15, no. 1 (2021): 132. https://doi.org/10.3892/mco.2021.2294
Copy and paste a formatted citation
x
Spandidos Publications style
Xie L, Li Q, Dong X, Kong Q, Duan Y, Chen X, Li X, Hong M and Liu T: Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai. Mol Clin Oncol 15: 132, 2021.
APA
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X. ... Liu, T. (2021). Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai. Molecular and Clinical Oncology, 15, 132. https://doi.org/10.3892/mco.2021.2294
MLA
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X., Li, X., Hong, M., Liu, T."Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai". Molecular and Clinical Oncology 15.1 (2021): 132.
Chicago
Xie, L., Li, Q., Dong, X., Kong, Q., Duan, Y., Chen, X., Li, X., Hong, M., Liu, T."Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai". Molecular and Clinical Oncology 15, no. 1 (2021): 132. https://doi.org/10.3892/mco.2021.2294
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