Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
August-2021 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2021 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia

  • Authors:
    • Alinne Ayulieth Rivas‑Alarcón
    • Yazmin Gómez‑Gómez
    • Jorge Organista‑Nava
    • Marco Antonio Jiménez‑López
    • Ana Berta Rivera‑Ramírez
    • Eloisa Ibarra‑Sierra
    • Mónica Virginia Saavedra‑Herrera
    • Berenice Illades‑Aguiar
    • Marco Antonio Leyva‑Vázquez
  • View Affiliations / Copyright

    Affiliations: Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39070, México, Departamento de Investigación, Instituto Estatal de Cancerología ‘Arturo Beltrán Ortega’, Acapulco, Guerrero 39570, México
    Copyright: © Rivas‑Alarcón et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 168
    |
    Published online on: June 18, 2021
       https://doi.org/10.3892/mco.2021.2330
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Abstract. YKL‑40, also known as chitinase‑3‑like protein 1 (CHI3L1), is an inflammatory glycoprotein secreted by different types of cells, such as inflammatory cells. The levels of this protein are elevated in the serum or plasma of patients with different types of cancer, and high concentrations are associated with poor prognosis and short survival in patients with liver, breast, lung, bladder and endometrial cancers. In Mexico, acute lymphoblastic leukemia (ALL) is the most common type of cancer affecting the pediatric population. The prognosis of patients with ALL is difficult to establish. Hence, the objective of the present study was to analyze the plasma levels of YKL‑40 in Mexican children with ALL and investigate its role as a prognostic factor. A case‑control study was performed in a population of 90 children aged 1‑18 years, among whom 45 had ALL and 45 were hematologically healthy. The levels of YKL‑40 in plasma samples were measured using ELISA and were found to be significantly higher in children with ALL compared with those in controls (P<0.0001). Children with ALL who had high plasma levels of YKL‑40 (≥36.34 ng/ml) had shorter survival compared with those with low levels (<36.34 ng/ml; P<0.05). The findings of the present study revealed that the YKL‑40 plasma level, age/initial leukocyte count and central nervous system invasion were associated with the prognosis of children with ALL [odds ratio (OR)=6.06, 95% confidence interval (CI): 1.1‑31.6, P=0.03; OR=8.53, 95% CI: 1.2‑58.2, P=0.03; and OR=6.45, 95% CI: 1.01‑41.2, P=0.04, respectively]. Therefore, YKL‑40 plasma levels may serve as a prognostic biomarker in pediatric patients with ALL.
View Figures

Figure 1

Figure 2

View References

1 

Centro Nacional para la Salud de la Infancia y la Adolescencia. (CENSIA): Comportamiento epidemiológico del cáncer en menores de 18 años. México 2008-2014. Secretaria de Salud, 2014. http://censia.salud.gob.mx/contenidos/descargas/cancer/20160601_Boletin2014_SEDP12sep16_4.pdf.

2 

Smith MA, Seibel NL, Altekruse SF, Ries LA, Melbert DL, O'Leary M, Smith FO and Reamen GH: Outcomes for children and adolescents with cancer: Challenges for the twenty-first century. Int J Clin Oncol. 28:2625–2634. 2010.PubMed/NCBI View Article : Google Scholar

3 

Rendón-Macías ME, Reyes-Zepeda NC, Villasís-Keever MÁ, Meneses SJ and Núñez AE: Tendencia mundial de la supervivencia en pacientes pediátricos con leucemia linfoblástica aguda. Revisión de las últimas cuatro décadas. Bol Med Hosp Infant Mex. 69:153–163. 2012.

4 

Layton-Tovar C: Factores de pronóstico en leucemia linfoblástica aguda pediátrica: Posibles marcadores moleculares. Rev Med Investig. 3:85–91. 2015.

5 

Terwilliger T and Abdul-Hay M: Acute lymphoblastic leukemia: A comprehensive review and update. Blood Cancer J. 7(e577)2017.PubMed/NCBI View Article : Google Scholar

6 

Johansen JS, Hoyer PE, Larsen LA, Price PA and Møllgård K: YKL-40 protein expression in the early developing human musculoskeletal system. J Histochem Cytochem. 55:1213–1228. 2007.PubMed/NCBI View Article : Google Scholar

7 

Johansen JS, Jensen BV, Roslind A, Nielsen D and Price P: Serum YKL-40, a new prognostic biomarker in cancer patients? Cancer Epidemiol Biomarkers Prev. 15:194–202. 2006.PubMed/NCBI View Article : Google Scholar

8 

Prakash M, Bodas M, Prakash D, Nawani N, Khetmalas M, Mandal A and Eriksson C: Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling. Cell Signal. 25:1567–1573. 2013.PubMed/NCBI View Article : Google Scholar

9 

Chen HT, Zheng JM, Zhang YZ, Yang M, Wang YL, Man XH, Chen Y, Cai QC and Li ZS: Overexpression of YKL-40 predicts poor prognosis in patients undergoing curative resection of pancreatic cancer. J Pancreas. 46:323–334. 2017.PubMed/NCBI View Article : Google Scholar

10 

Kang EJ, Jung H, Woo OH, Park KH, Woo SU, Yang DS, Kim AR, Lee JB, Kim YH, Kim JS and Seo JH: YKL-40 expression could be a poor prognostic marker in the breast cancer tissue. Tumor Biol. 35:277–286. 2014.PubMed/NCBI View Article : Google Scholar

11 

Steponaitis G, Skiriutė D, Kazlauskas A, Golubickaitė I, Stakaitis R, Tamašauskas A and Vaitkienė P: High CHI3L1 expression is associated with glioma patient survival. Diagn Pathol. 11(42)2016.PubMed/NCBI View Article : Google Scholar

12 

Erturk K, Tas F, Serilmez M, Bilgin E and Yasasever V: Clinical significance of serum Ykl-40 (chitinase-3-like-1 protein) as a biomarker in melanoma: An analysis of 112 Turkish patients. Asian Pac J Cancer Prev. 18:1383–1387. 2017.PubMed/NCBI View Article : Google Scholar

13 

Schultz NA and Johansen JS: YKL-40-A protein in the field of translational medicine: A role as a biomarker in cancer patients? Cancers (Basel). 2:1453–1491. 2010.PubMed/NCBI View Article : Google Scholar

14 

Volck B, Johansen JS, Stoltenberg M, Garbarsch C, Price PA, Ostergaard M, Ostergaard K, Løvgreen-Nielsen P, Sonne-Holm S and Lorenzen I: Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology. Osteoarthritis Cartilage. 9:203–214. 2001.PubMed/NCBI View Article : Google Scholar

15 

Chupp GL, Lee CG, Jarjour N, Shim YM, Holm CT, He S, Dziura JD, Reed J, Coyle AJ, Kiener P, et al: A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med. 357:2016–2027. 2007.PubMed/NCBI View Article : Google Scholar

16 

Letuve S, Kozhich A, Arouche N, Grandsaigne M, Reed J, Dombret MC, Kiener PA, Aubier M, Coyle AJ and Pretolani M: YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol. 181:5167–5173. 2008.PubMed/NCBI View Article : Google Scholar

17 

Boot RG, Van Achterberg TA, Van Aken BE, Renkema GH, Jacobs MJ, Aerts JM and de Vries CJ: Strong induction of members of the chitinase family of proteins in atherosclerosis. Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler Thromb Vasc Biol. 19:687–694. 1999.PubMed/NCBI View Article : Google Scholar

18 

Rathcke CN, Johansen JS and Vestergaard H: YKL-40, a biomarker of inflammation, is elevated in patients with type 2 diabetes and is related to insulin resistance. Inflamm Re. 55:53–59. 2006.PubMed/NCBI View Article : Google Scholar

19 

Bergmann OJ, Johansen JS, Klausen TW, Mylin AK, Kristensen JS, Kjeldsen E and Johnsen HE: High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia. Clin Can Res. 11:8644–8652. 2005.PubMed/NCBI View Article : Google Scholar

20 

Hurmale AK, Choudhary SK, Bhaskar SK, Jatawa SK, Yadav M and Tiwari A: Overexpression of chitinase like protein YKL-40 in leukemia patients. J BioSci Biotech. 2:215–220. 2013.

21 

Organista-Nava J, Gómez-Gómez Y, Illades-Aguiar B, Del Carmen Alarcón-Romero L, Saavedra-Herrera MV, Rivera-Ramírez AB, Garzón-Barrientos VH and Leyva-Vázquez MA: High miR-24 expression is associated with risk of relapse and poor survival in acute leukemia. Oncol Rep. 33:1639–1649. 2015.PubMed/NCBI View Article : Google Scholar

22 

US Food, Drug Administration: Clinical trial endpoints for the approval of cancer drugs and biologics: Guidance for industry. https://www.fda.gov/media/71195/download. Published December 2018. Accessed August 14, 2019.

23 

Wang D, Zhai B, Hu F, Liu C, Zhao J and Xu J: High YKL-40 serum concentration is correlated with prognosis of Chinese patients with breast cancer. PLoS One. 7(e51127)2012.PubMed/NCBI View Article : Google Scholar

24 

Thongsom S, Chaocharoen W, Silsirivanit A, Wongkham S, Sripa B, Choe H, Suginta W and Talabnin C: YKL-40/chitinase-3-like protein 1 is associated with poor prognosis and promotes cell growth and migration of cholangiocarcinoma. Tumor Biol. 37:9451–9463. 2016.PubMed/NCBI View Article : Google Scholar

25 

Xu CH, Yu LK and Hao KK: Serum YKL-40 level is associated with the chemotherapy response and prognosis of patients with small cell lung cancer. PLoS One. 9(e96384)2014.PubMed/NCBI View Article : Google Scholar

26 

Kotowicz B, Fuksiewicz M, Jonska-Gmyrek J, Wagrodzki M and Kowalska M: Preoperative serum levels of YKL 40 and CA125 as a prognostic indicators in patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol. 215:141–147. 2017.PubMed/NCBI View Article : Google Scholar

27 

Zhang JP, Yuan HX, Kong WT, Liu Y, Lin ZM, Wangs WP and Guo JM: Increased expression of Chitinase 3-like 1 and microvessel density predicts metastasis and poor prognosis in clear cell renal cell carcinoma. Tumour Biol. 35:12131–12137. 2014.PubMed/NCBI View Article : Google Scholar

28 

Ringsholt M, Hogdall EV, Johansen JS, Price PA and Christensen LH: YKL-40 protein expression in normal adult human tissues-an immunohistochemical study. J Mol Histol. 38:33–43. 2007.PubMed/NCBI View Article : Google Scholar

29 

Borowitz MJ, Devidas M, Hunger SP, Bowman WP, Carroll AJ, Carroll WL, Linda S, Martin PL, Pullen DJ, Viswanatha D, et al: Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A children's oncology groups study. Blood. 111:5477–5485. 2008.PubMed/NCBI View Article : Google Scholar

30 

Lenk L, Alsadeq A and Schewe DM: Involvement of the central nervous system in acute lymphoblastic leukemia: Opinions on molecular mechanisms and clinical implications based on recent data. Cancer Metastasis Rev. 39:173–187. 2020.PubMed/NCBI View Article : Google Scholar

31 

Shao R, Hamel K, Petersen L, Cao QJ, Arenas RB, Bigelow C, Bentley B and Yan W: YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene. 28:4456–4468. 2009.PubMed/NCBI View Article : Google Scholar

32 

Recklies AD, White C and Ling H: The chitinase 3-like protein human cartilage glycoprotein 39 (HC-gp39) stimulates proliferation of human connective-tissue cells and activates both extracellular signal regulated kinase- and protein kinase B-mediated signalling pathways. Biochem J. 365:119–126. 2002.PubMed/NCBI View Article : Google Scholar

33 

Johansen JS, Drivsholm L, Price PA and Christensen IJ: High serum YKL-40 level in patients with small cell lung cancer is related to early death. Lung Cancer. 46:333–340. 2004.PubMed/NCBI View Article : Google Scholar

34 

Sanchez VE, Nichols C, Kim HN, Gang EJ and Kim YM: Targeting PI3K signaling in acute lymphoblastic leukemia. Int J Mol Sci. 20(412)2019.PubMed/NCBI View Article : Google Scholar

35 

Hoellenriegel J, Meadows SA, Sivina M, Wierda WG, Kantarjian H, Keating MJ, Giese N, O'Brien S, Yu A, Miller LL, et al: The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood. 118:3603–3612. 2011.PubMed/NCBI View Article : Google Scholar

36 

Billottet C, Grandage VL, Gale RE, Quattropani A, Rommel C, Vanhaesebroeck B and Khwaja A: A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16. Oncogene. 25:6648–6659. 2006.PubMed/NCBI View Article : Google Scholar

37 

Bojesen SE, Johansen JS and Nordestgaard BG: Plasma YKL-40 levels in healthy subjects from the general population. Clin Chim Acta. 412:709–712. 2011.PubMed/NCBI View Article : Google Scholar

38 

Johansen JS: Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull. 53:172–209. 2006.PubMed/NCBI

39 

Recklies AD, Ling H, White C and Bernier SM: Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes. J Biol Chem. 280:41213–41221. 2005.PubMed/NCBI View Article : Google Scholar

40 

Johansen JS, Lottenburger T, Nielsen HJ, Jensen JE, Svendsen MN, Kollerup G and Christensen IJ: Diurnal, weekly, and long-time variation in serum concentrations of YKL-40 in healthy subjects. Cancer Epidemiol Biomarkers Prev. 17:2603–2608. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Rivas‑Alarcón AA, Gómez‑Gómez Y, Organista‑Nava J, Jiménez‑López MA, Rivera‑Ramírez AB, Ibarra‑Sierra E, Saavedra‑Herrera MV, Illades‑Aguiar B and Leyva‑Vázquez MA: Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia. Mol Clin Oncol 15: 168, 2021.
APA
Rivas‑Alarcón, A.A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M.A., Rivera‑Ramírez, A.B., Ibarra‑Sierra, E. ... Leyva‑Vázquez, M.A. (2021). Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia. Molecular and Clinical Oncology, 15, 168. https://doi.org/10.3892/mco.2021.2330
MLA
Rivas‑Alarcón, A. A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M. A., Rivera‑Ramírez, A. B., Ibarra‑Sierra, E., Saavedra‑Herrera, M. V., Illades‑Aguiar, B., Leyva‑Vázquez, M. A."Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia". Molecular and Clinical Oncology 15.2 (2021): 168.
Chicago
Rivas‑Alarcón, A. A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M. A., Rivera‑Ramírez, A. B., Ibarra‑Sierra, E., Saavedra‑Herrera, M. V., Illades‑Aguiar, B., Leyva‑Vázquez, M. A."Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia". Molecular and Clinical Oncology 15, no. 2 (2021): 168. https://doi.org/10.3892/mco.2021.2330
Copy and paste a formatted citation
x
Spandidos Publications style
Rivas‑Alarcón AA, Gómez‑Gómez Y, Organista‑Nava J, Jiménez‑López MA, Rivera‑Ramírez AB, Ibarra‑Sierra E, Saavedra‑Herrera MV, Illades‑Aguiar B and Leyva‑Vázquez MA: Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia. Mol Clin Oncol 15: 168, 2021.
APA
Rivas‑Alarcón, A.A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M.A., Rivera‑Ramírez, A.B., Ibarra‑Sierra, E. ... Leyva‑Vázquez, M.A. (2021). Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia. Molecular and Clinical Oncology, 15, 168. https://doi.org/10.3892/mco.2021.2330
MLA
Rivas‑Alarcón, A. A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M. A., Rivera‑Ramírez, A. B., Ibarra‑Sierra, E., Saavedra‑Herrera, M. V., Illades‑Aguiar, B., Leyva‑Vázquez, M. A."Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia". Molecular and Clinical Oncology 15.2 (2021): 168.
Chicago
Rivas‑Alarcón, A. A., Gómez‑Gómez, Y., Organista‑Nava, J., Jiménez‑López, M. A., Rivera‑Ramírez, A. B., Ibarra‑Sierra, E., Saavedra‑Herrera, M. V., Illades‑Aguiar, B., Leyva‑Vázquez, M. A."Plasma levels of YKL‑40 as a prognostic factor in childhood acute lymphoblastic leukemia". Molecular and Clinical Oncology 15, no. 2 (2021): 168. https://doi.org/10.3892/mco.2021.2330
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team