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Article

Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up

  • Authors:
    • Aron Gortman
    • Noel J. Aherne
    • Justin Westhuyzen
    • Julan V. Amalaseelan
    • Patrick M. Dwyer
    • Matthew Hoffmann
    • Andrew T. Last
    • Thomas P. Shakespeare
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales 2450, Australia, Department of Radiation Oncology, North Coast Cancer Institute, Lismore, New South Wales 2480, Australia, Department of Radiation Oncology, Mid North Coast Cancer Institute, Port Macquarie, New South Wales 2444, Australia
  • Article Number: 178
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    Published online on: July 1, 2021
       https://doi.org/10.3892/mco.2021.2340
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Abstract

Metaplastic breast carcinoma is an uncommon subtype of invasive ductal carcinoma with a tendency towards poorer clinical outcomes. Following ethical approval, the current study reviewed the institutional records of ~2,500 women with breast cancer. A total of 14 cases of metaplastic breast cancer were reviewed for management and treatment outcomes. The results demonstrated that patients had median follow up of 30 months, a 5‑year disease‑free survival of 57.1% and 5‑year overall survival of 57.1%. The majority of patients had at least T2 disease and all tumours were high grade. Additionally, most patients were triple negative and nodal metastases were uncommon. Metaplastic breast cancer is an aggressive variant of invasive breast cancer. Most patients can be treated with breast conservation and survival parameters tend to be worse than more common breast cancer subtypes.
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Copy and paste a formatted citation
Spandidos Publications style
Gortman A, Aherne NJ, Westhuyzen J, Amalaseelan JV, Dwyer PM, Hoffmann M, Last AT and Shakespeare TP: Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up. Mol Clin Oncol 15: 178, 2021.
APA
Gortman, A., Aherne, N.J., Westhuyzen, J., Amalaseelan, J.V., Dwyer, P.M., Hoffmann, M. ... Shakespeare, T.P. (2021). Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up. Molecular and Clinical Oncology, 15, 178. https://doi.org/10.3892/mco.2021.2340
MLA
Gortman, A., Aherne, N. J., Westhuyzen, J., Amalaseelan, J. V., Dwyer, P. M., Hoffmann, M., Last, A. T., Shakespeare, T. P."Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up". Molecular and Clinical Oncology 15.3 (2021): 178.
Chicago
Gortman, A., Aherne, N. J., Westhuyzen, J., Amalaseelan, J. V., Dwyer, P. M., Hoffmann, M., Last, A. T., Shakespeare, T. P."Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up". Molecular and Clinical Oncology 15, no. 3 (2021): 178. https://doi.org/10.3892/mco.2021.2340
Copy and paste a formatted citation
x
Spandidos Publications style
Gortman A, Aherne NJ, Westhuyzen J, Amalaseelan JV, Dwyer PM, Hoffmann M, Last AT and Shakespeare TP: Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up. Mol Clin Oncol 15: 178, 2021.
APA
Gortman, A., Aherne, N.J., Westhuyzen, J., Amalaseelan, J.V., Dwyer, P.M., Hoffmann, M. ... Shakespeare, T.P. (2021). Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up. Molecular and Clinical Oncology, 15, 178. https://doi.org/10.3892/mco.2021.2340
MLA
Gortman, A., Aherne, N. J., Westhuyzen, J., Amalaseelan, J. V., Dwyer, P. M., Hoffmann, M., Last, A. T., Shakespeare, T. P."Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up". Molecular and Clinical Oncology 15.3 (2021): 178.
Chicago
Gortman, A., Aherne, N. J., Westhuyzen, J., Amalaseelan, J. V., Dwyer, P. M., Hoffmann, M., Last, A. T., Shakespeare, T. P."Metaplastic carcinoma of the breast: Clinicopathological features and treatment outcomes with long‑term follow up". Molecular and Clinical Oncology 15, no. 3 (2021): 178. https://doi.org/10.3892/mco.2021.2340
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