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Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker

  • Authors:
    • Tatsuki Nanami
    • Isamu Hoshino
    • Fumiaki Shiratori
    • Satoshi Yajima
    • Yoko Oshima
    • Takashi Suzuki
    • Masaaki Ito
    • Takaki Hiwasa
    • Akiko Kuwajima
    • Hideaki Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Toho University, Tokyo 143‑8541, Japan, Division of Gastroenterological Surgery, Chiba Cancer Center, Chiba 260‑8717, Japan, Department of Clinical Oncology, Graduate School of Medicine, Toho University, Tokyo 143‑8541, Japan, Medical and Biological Laboratories Co., Ltd., Nagoya, Aichi 460‑0008, Japan
    Copyright: © Nanami et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 179
    |
    Published online on: July 1, 2021
       https://doi.org/10.3892/mco.2021.2341
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Abstract

Although serum galectin‑1 antibodies (s‑GAL‑1‑Abs) have been evaluated in a small number of patients with cancer, a large series of patients with different cancer types have not been reported. The current study evaluated 1,833 patients with esophageal cancer (n=172), gastric cancer (n=317), colorectal cancer (n=262), hepatocellular carcinoma (n=91), prostate cancer (n=358), breast cancer (n=364), lung cancer (n=269) and 72 healthy individuals. s‑GAL‑1‑Abs levels were analyzed using an originally developed ELISA system. A cut‑off optical density value was determined as the mean (0.053) + 3 standard deviations (0.105) of sera from healthy controls. The results revealed that the positive rate of s‑GAL‑1‑Abs in patients with hepatocellular carcinoma (16.7%) and lung cancer (13.8%) were significantly higher compared with the other groups: Esophageal cancer (11.6%), colorectal cancer (11.5%), prostate cancer (7.3%), gastric cancer (6.9%), breast cancer (6.9%) and healthy controls (4.2%). Although the positive rates of s‑GAL‑1‑Abs in different cancer types were relatively low, s‑GAL‑1‑Abs may be useful for patients with hepatocellular carcinoma and lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Nanami T, Hoshino I, Shiratori F, Yajima S, Oshima Y, Suzuki T, Ito M, Hiwasa T, Kuwajima A, Shimada H, Shimada H, et al: Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Mol Clin Oncol 15: 179, 2021.
APA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T. ... Shimada, H. (2021). Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Molecular and Clinical Oncology, 15, 179. https://doi.org/10.3892/mco.2021.2341
MLA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15.3 (2021): 179.
Chicago
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15, no. 3 (2021): 179. https://doi.org/10.3892/mco.2021.2341
Copy and paste a formatted citation
x
Spandidos Publications style
Nanami T, Hoshino I, Shiratori F, Yajima S, Oshima Y, Suzuki T, Ito M, Hiwasa T, Kuwajima A, Shimada H, Shimada H, et al: Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Mol Clin Oncol 15: 179, 2021.
APA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T. ... Shimada, H. (2021). Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker. Molecular and Clinical Oncology, 15, 179. https://doi.org/10.3892/mco.2021.2341
MLA
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15.3 (2021): 179.
Chicago
Nanami, T., Hoshino, I., Shiratori, F., Yajima, S., Oshima, Y., Suzuki, T., Ito, M., Hiwasa, T., Kuwajima, A., Shimada, H."Prevalence of serum galectin‑1 autoantibodies in seven types of cancer: A potential biomarker". Molecular and Clinical Oncology 15, no. 3 (2021): 179. https://doi.org/10.3892/mco.2021.2341
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