Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2021 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report

  • Authors:
    • Georgios Boutzios
    • Eleni Papaoiconomou
    • Andreas Pikoulis
    • Konstantinos Nastos
    • Despoina Pouloudi
    • Anastasia Pikouli
    • Eleni Koukoulioti
    • Andreas Lazaris
    • Emmanouil Pikoulis
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, Laiko University Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Third Department of Surgery, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece, First Department of Pathology Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece
  • Article Number: 200
    |
    Published online on: August 8, 2021
       https://doi.org/10.3892/mco.2021.2362
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) have been hypothesized to arise from well‑differentiated thyroid carcinoma (WDTC) due to frequently reported synchronous and metachronous occurrence. Loss of normal p53 function has been implicated in this dedifferentiation process. The current case report presents a 60‑year‑old male with multiple neurofibromas who underwent total thyroidectomy due to multiple palpable thyroid nodules. Histopathological examination revealed three foci of predominantly papillary, but also follicular carcinoma growth pattern, and two lesions with histological features of insular and trabecular variant, with the larger one showing foci of anaplastic transition. Nuclear p53 protein accumulation, corresponding to mutant abnormally stabilized p53, was higher in more aggressive variants compared with WDTC. The somatic molecular events and downstream pathways of this dedifferentiation course have not been unraveled yet. The present case report demonstrated the simultaneous presence of three divergent histological subtypes in a single thyroid gland, with progressive enhancement of nuclear p53 protein expression, associated with mutant p53 protein, in the more aggressive variants. This is a rare case of progressive enhancement of mutant nuclear p53 protein expression in multifocal thyroid tumor areas consisting of WDTC, PDTC and ATC histological types, highlighting the possibility that WDTC can progress to PDTC and then ATC through an intricate procedure, involving loss of normal p53 function.
View Figures

Figure 1

View References

1 

DeLellis RA, Lloyd VR, Heitz PU and Eng C (eds): World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs. IARC Press, Lyon, 2004.

2 

Sadow PM and Faquin WC: Poorly differentiated thyroid carcinoma: An incubating entity. Front Endocrinol (Lausanne). 3(77)2012.PubMed/NCBI View Article : Google Scholar

3 

Tallini G: Poorly differentiated thyroid carcinoma. Are we there yet? Endocr Pathol. 22:190–194. 2011.PubMed/NCBI View Article : Google Scholar

4 

Volante M, Collini P, Nikiforov YE, Sakamoto A, Kakudo K, Katoh R, Lloyd RV, LiVolsi VA, Papotti M, Sobrinho-Simoes M, et al: Poorly differentiated thyroid carcinoma: The turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol. 31:1256–1264. 2007.PubMed/NCBI View Article : Google Scholar

5 

Garcia-Rostan G and Sobrinho-Simões M: Poorly differentiated thyroid carcinoma: An evolving entity. Diagnostic Histopathol. 17:114–123. 2011.

6 

Volante M and Papotti M: Poorly differentiated thyroid carcinoma: 5 years after the 2004 WHO classification of endocrine tumours. Endocr Pathol. 21:1–6. 2010.PubMed/NCBI View Article : Google Scholar

7 

Eloy C, Ferreira L, Salgado C, Soares P and Sobrinho-Simões M: Poorly differentiated and undifferentiated thyroid carcinomas. Turk Patoloji Derg. 31 (Suppl 1):S48–S59. 2015.PubMed/NCBI View Article : Google Scholar

8 

Omur O and Baran Y: An update on molecular biology of thyroid cancers. Crit Rev Oncol Hematol. 90:233–252. 2014.PubMed/NCBI View Article : Google Scholar

9 

Walczyk A, Kowalska A and Sygut J: The clinical course of poorly differentiated thyroid carcinoma (insular carcinoma)-own observations. Endokrynol Pol. 61:467–473. 2010.PubMed/NCBI

10 

Quiros RM, Ding HG, Gattuso P, Prinz RA and Xu X: Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. Cancer. 103:2261–2268. 2005.PubMed/NCBI View Article : Google Scholar

11 

Levine AJ: p53, the cellular gatekeeper for growth and division. Cell. 88:323–331. 1997.PubMed/NCBI View Article : Google Scholar

12 

Midgley CA and Lane DP: p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene. 15:1179–1189. 1997.PubMed/NCBI View Article : Google Scholar

13 

Yemelyanova A, Vang R, Kshirsagar M, Lu D, Marks MA, Shih IM and Kurman RJ: Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: An immunohistochemical and nucleotide sequencing analysis. Mod Pathol. 24:1248–1253. 2011.PubMed/NCBI View Article : Google Scholar

14 

Lam KY, Lo CY, Chan KW and Wan KY: Insular and anaplastic carcinoma of the thyroid: A 45-year comparative study at a single institution and a review of the significance of p53 and p21. Ann Surg. 231(329)2000.PubMed/NCBI View Article : Google Scholar

15 

McIver B, Hay ID, Giuffrida DF, Dvorak CE, Grant CS, Thompson GB, van Heerden JA and Goellner JR: Anaplastic thyroid carcinoma: A 50-year experience at a single institution. Surgery. 130:1028–1034. 2001.PubMed/NCBI View Article : Google Scholar

16 

Penna GC, Vaisman F, Vaisman M, Sobrinho-Simoes M and Soares P: Molecular markers involved in tumorigenesis of thyroid carcinoma: Focus on aggressive histotypes. Cytogenet Genome Res. 150:194–207. 2016.PubMed/NCBI View Article : Google Scholar

17 

Manzella L, Stella S, Pennisi MS, Tirro E, Massimino M, Romano C, Puma A, Tavarelli M and Vigneri P: New insights in thyroid cancer and p53 family proteins. Int J Mol Sci. 18(1325)2017.PubMed/NCBI View Article : Google Scholar

18 

Marcello MA, Morari EC, Cunha LL, De Nadai Silva AC, Carraro DM, Carvalho AL, Soares FA, Vassallo J and Ward LS: P53 and expression of immunological markers may identify early stage thyroid tumors. Clin Dev Immunol. 2013(846584)2013.PubMed/NCBI View Article : Google Scholar

19 

Shin MK, Kim JW, Min SK, Lee DJ, Kim JH, Lee SC, Chung BW and Ju YS: Associations of the BRAF (V600E) mutation and p53 protein expression with clinicopathological features of papillary thyroid carcinomas patients. Oncol Lett. 10:1882–1888. 2015.PubMed/NCBI View Article : Google Scholar

20 

Sanders EM Jr, LiVolsi VA, Brierley J, Shin J and Randolph GW: An evidence-based review of poorly differentiated thyroid cancer. World J Surg. 31:934–945. 2007.PubMed/NCBI View Article : Google Scholar

21 

Collini P, Mattavelli F, Pellegrinelli A, Barisella M, Ferrari A and Massimino M: Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: A clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period. Am J Surg Pathol. 30:1420–1426. 2006.PubMed/NCBI View Article : Google Scholar

22 

Hannallah J, Rose J and Guerrero MA: Comprehensive literature review: Recent advances in diagnosing and managing patients with poorly differentiated thyroid carcinoma. Int J Endocrinol. 2013(317487)2013.PubMed/NCBI View Article : Google Scholar

23 

Hashiba T, Maruno M, Fujimoto Y, Suzuki T, Wada K, Isaka T, Izumoto S and Yoshimine T: Skull metastasis from papillary thyroid carcinoma accompanied by neurofibromatosis type 1 and pheochromocytoma: Report of a case. Brain Tumor Pathol. 23:97–100. 2006.PubMed/NCBI View Article : Google Scholar

24 

Kim BK, Choi YS, Gwoo S, Park YH, Yang SI and Kim JH: Neurofibromatosis type 1 associated with papillary thyroid carcinoma incidentally detected by thyroid ultrasonography: A case report. J Med Case Rep. 6(179)2012.PubMed/NCBI View Article : Google Scholar

25 

Koksal Y, Sahin M, Koksal H, Esen H and Sen M: Neurofibroma adjacent to the thyroid gland and a thyroid papillary carcinoma in a patient with neurofibromatosis type 1: Report of a case. Surg Today. 39:884–887. 2009.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Boutzios G, Papaoiconomou E, Pikoulis A, Nastos K, Pouloudi D, Pikouli A, Koukoulioti E, Lazaris A and Pikoulis E: p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report. Mol Clin Oncol 15: 200, 2021.
APA
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A. ... Pikoulis, E. (2021). p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report. Molecular and Clinical Oncology, 15, 200. https://doi.org/10.3892/mco.2021.2362
MLA
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A., Koukoulioti, E., Lazaris, A., Pikoulis, E."p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report". Molecular and Clinical Oncology 15.4 (2021): 200.
Chicago
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A., Koukoulioti, E., Lazaris, A., Pikoulis, E."p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 200. https://doi.org/10.3892/mco.2021.2362
Copy and paste a formatted citation
x
Spandidos Publications style
Boutzios G, Papaoiconomou E, Pikoulis A, Nastos K, Pouloudi D, Pikouli A, Koukoulioti E, Lazaris A and Pikoulis E: p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report. Mol Clin Oncol 15: 200, 2021.
APA
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A. ... Pikoulis, E. (2021). p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report. Molecular and Clinical Oncology, 15, 200. https://doi.org/10.3892/mco.2021.2362
MLA
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A., Koukoulioti, E., Lazaris, A., Pikoulis, E."p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report". Molecular and Clinical Oncology 15.4 (2021): 200.
Chicago
Boutzios, G., Papaoiconomou, E., Pikoulis, A., Nastos, K., Pouloudi, D., Pikouli, A., Koukoulioti, E., Lazaris, A., Pikoulis, E."p53 protein expression in synchronously occurring dedifferentiating stages of thyroid cancer in a patient with neurofibromas: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 200. https://doi.org/10.3892/mco.2021.2362
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team