Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
October-2021 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor

  • Authors:
    • Naoya Kitamura
    • Shinya Sento
    • Eri Sasabe
    • Katsuhito Kiyasu
    • Kosuke Nakaji
    • Masanori Daibata
    • Tetsuya Yamamoto
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Kochi 783‑8505, Japan, Department of Orthopedic Surgery, Kochi Medical School, Kochi University, Kochi 783‑8505, Japan, Department of Radiology, Kochi Medical School, Kochi University, Kochi 783‑8505, Japan, Department of Microbiology and Infection, Kochi Medical School, Kochi University, Nankoku, Kochi 783‑8505, Japan
    Copyright: © Kitamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 202
    |
    Published online on: August 8, 2021
       https://doi.org/10.3892/mco.2021.2364
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Granulocyte colony‑stimulating factor (G‑CSF)-producing tumors are rare and are associated with a poor prognosis when they occur in the lungs and the head and neck region. Positron emission tomography/computed tomography has been reported to show systemic specific accumulation of fluorodeoxyglucose in these cases, but the systemic complications associated with the cytokines produced are not well known. We herein present the case of a G‑CSF‑producing maxillary sinus squamous cell carcinoma in a 73‑year‑old Japanese woman with a vertebral fracture and splenomegaly. These findings are known severe adverse events of high‑dose recombinant human G‑CSF treatment. The aim of the present study was to further discuss the hypothesis that cytokines produced by solid tumors may induce spinal vertebral fracture and splenomegaly.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Kaneko N, Kawano S, Matsubara R, Goto Y, Jinno T, Maruse Y, Sakamoto T, Hashiguchi Y, Iida M and Nakamura S: Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: A case report and literature review. World J Surg Oncol. 14(161)2018.PubMed/NCBI View Article : Google Scholar

2 

Asano S, Urabe A, Okabe T, Sato N and Kondo Y: Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 49:845–852. 1977.PubMed/NCBI

3 

Yakisan E, Schirg E, Zeidler C, Bishop NJ, Reiter A, Hirt A, Riehm H and Welte K: High incidence of significant bone loss in patients with severe congenital neutropenia (Kostmann's syndrome). J Pediatr. 131:592–597. 1997.PubMed/NCBI View Article : Google Scholar

4 

Takamatsu Y, Simmons PJ, Moore RJ, Morris HA, To LB and Lévesque JP: Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization. Blood. 92:3465–3473. 1998.PubMed/NCBI

5 

Sidan L, Tianshou L, Yongbing C, Yinchao N, Changhong L, Lanting L, Qiaochuan L and Lugui Q: Granulocyte colony-stimulating factor induces osteoblast inhibition by B lymphocytes and osteoclast activation by T lymphocytes during hematopoietic stem/progenitor cell mobilization. Biol Blood Marrow Transplant. 21:1384–1391. 2015.PubMed/NCBI View Article : Google Scholar

6 

Turhan AB, Binay C, Bor O and Simsek E: The effects of short-term use of granulocyte colony-stimulating factor on bone metabolism in child cancer patients. Norh Clin Istanb. 5:277–281. 2018.PubMed/NCBI View Article : Google Scholar

7 

Goshen E, Tima Davidson T, Yeshurun M and Zwas ST: Combined increased and decreased skeletal uptake of F-18 FDG. Clin Nucl Med. 31:520–522. 2006.PubMed/NCBI View Article : Google Scholar

8 

Christopher MJ and Link DC: Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res. 23:1765–1774. 2008.PubMed/NCBI View Article : Google Scholar

9 

Kusumahstuti KP, Watabe T, Kitamura N and Yamamoto T: Diffuse bone marrow uptake related to granulocyte colony-stimulating factor-producing maxillary sinus carcinoma on 4-borono-2-18F-fluoro-L-phenylalanine positron emission tomography/computed tomography. World J Nucl Med. 20:188–191. 2021.PubMed/NCBI View Article : Google Scholar

10 

Morooka M, Kubota K, Murata Y, Shibuya H, Ito K, Mochizuki M, Akashi T, Chiba T, Nomura T, Ito H and Morita T: (18)F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors. Ann Nucl Med. 22:635–639. 2008.PubMed/NCBI View Article : Google Scholar

11 

Kuroshima T, Wada M, Sato T, Takano M and Makino S: G-CSF producing oral carcinoma with diffuse uptake of FDG in the bone marrow: A case report. Oncol Lett. 15:1241–1245. 2018.PubMed/NCBI View Article : Google Scholar

12 

Pfister DG, Spencer S, Adelstein D, Adkins D, Anzai Y, Brizel DM, Bruce JY, Busse PM, Caudell JJ, Cmelak AJ, et al: Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 18:873–898. 2020.PubMed/NCBI View Article : Google Scholar

13 

Picardi M, Rosa GD, Selleri C, Scarpato N, Soscia E, Martinelli V, Ciancia R and Rotoli B: Spleen enlargement following recombinant human granulocyte colony-stimulating factor administration for peripheral blood stem cell mobilization. Haematologica. 88:794–800. 2003.PubMed/NCBI

14 

Al-Khinji A and Linenberger M: Splenic infarction and G-CSF. Transfusion. 55(708)2015.PubMed/NCBI View Article : Google Scholar

15 

Aubrey-Bassler FK and Sowers N: 613 cases of splenic rupture without risk factors or previously diagnosed disease: A systematic review. BMC Emerg Med. 12(11)2012.PubMed/NCBI View Article : Google Scholar

16 

Alshamrani MA, Al-Foheidi M and Abdulrahim AH: Granulocyte colony stimulating factor (G-CSF) induced splenic infarction in breast cancer patient treated with dose-dense chemotherapy regimen. Case Rep Oncol Med. 8174986:2019.PubMed/NCBI View Article : Google Scholar

17 

Stroncek D, Shawker T, Follmann D and Leitman SF: G-CSF-induced spleen size changes in peripheral blood progenitor cell donors. Transfusion. 43:609–613. 2003.PubMed/NCBI View Article : Google Scholar

18 

Pitini V, Ciccolo A, Arrigo C, Aloi G, Micali C and Torre FL: Spontaneous rupture of spleen during periferal blood stem cell mobilization in a patient with breast cancer. Haematologica. 85:559–560. 2000.PubMed/NCBI

19 

Masood N, Shaikh AJ, Memon WA and Idress R: Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: A case report and review of literature. Cases J. 24(418)2008.PubMed/NCBI View Article : Google Scholar

20 

de Wolff JF, Planken EV and den Ottolander GJ: Extreme leucocytosis and splenomegaly in metastasized melanoma. Neth J Med. 62:164–167. 2004.PubMed/NCBI

21 

Tsuruta N, Yatsunami J, Takayama K, Nakanishi Y, Ichinose Y and Hara N: Granulocyte-macrophage-colony stimulating factor stimulates tumor invasiveness in squamous cell lung carcinoma. Cancer. 82:2173–2183. 1998.PubMed/NCBI

22 

Tomita T, Fujii M, Tokumaru Y, Imanishi Y, Kanke M, Yamashita T, Ishiguro R, Kanzaki J, Kameyama K and Otani Y: Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells. Cancer Lett. 156:83–91. 2000.PubMed/NCBI View Article : Google Scholar

23 

Sugimoto C, Fujieda S, Sunaga H, Noda I, Tanaka N, Kimura Y, Saito H and Matsukawa S: Granulocyte colony-stimulating factor (G-CSF)-mediated signaling regulates type IV collagenase activity in human head and neck cancer cells. Int J Cancer. 93:42–46. 2001.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kitamura N, Sento S, Sasabe E, Kiyasu K, Nakaji K, Daibata M and Yamamoto T: Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Mol Clin Oncol 15: 202, 2021.
APA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., & Yamamoto, T. (2021). Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Molecular and Clinical Oncology, 15, 202. https://doi.org/10.3892/mco.2021.2364
MLA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15.4 (2021): 202.
Chicago
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15, no. 4 (2021): 202. https://doi.org/10.3892/mco.2021.2364
Copy and paste a formatted citation
x
Spandidos Publications style
Kitamura N, Sento S, Sasabe E, Kiyasu K, Nakaji K, Daibata M and Yamamoto T: Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Mol Clin Oncol 15: 202, 2021.
APA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., & Yamamoto, T. (2021). Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Molecular and Clinical Oncology, 15, 202. https://doi.org/10.3892/mco.2021.2364
MLA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15.4 (2021): 202.
Chicago
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15, no. 4 (2021): 202. https://doi.org/10.3892/mco.2021.2364
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team