Open Access

Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor

  • Authors:
    • Naoya Kitamura
    • Shinya Sento
    • Eri Sasabe
    • Katsuhito Kiyasu
    • Kosuke Nakaji
    • Masanori Daibata
    • Tetsuya Yamamoto
  • View Affiliations

  • Published online on: August 8, 2021     https://doi.org/10.3892/mco.2021.2364
  • Article Number: 202
  • Copyright: © Kitamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Granulocyte colony‑stimulating factor (G‑CSF)-producing tumors are rare and are associated with a poor prognosis when they occur in the lungs and the head and neck region. Positron emission tomography/computed tomography has been reported to show systemic specific accumulation of fluorodeoxyglucose in these cases, but the systemic complications associated with the cytokines produced are not well known. We herein present the case of a G‑CSF‑producing maxillary sinus squamous cell carcinoma in a 73‑year‑old Japanese woman with a vertebral fracture and splenomegaly. These findings are known severe adverse events of high‑dose recombinant human G‑CSF treatment. The aim of the present study was to further discuss the hypothesis that cytokines produced by solid tumors may induce spinal vertebral fracture and splenomegaly.
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October-2021
Volume 15 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Kitamura N, Sento S, Sasabe E, Kiyasu K, Nakaji K, Daibata M and Yamamoto T: Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Mol Clin Oncol 15: 202, 2021
APA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., & Yamamoto, T. (2021). Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor. Molecular and Clinical Oncology, 15, 202. https://doi.org/10.3892/mco.2021.2364
MLA
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15.4 (2021): 202.
Chicago
Kitamura, N., Sento, S., Sasabe, E., Kiyasu, K., Nakaji, K., Daibata, M., Yamamoto, T."Vertebral fracture and splenomegaly in a head and neck cancer producing granulocyte colony‑stimulating factor: A case report of systemic complications associated with a cytokine‑producing solid tumor". Molecular and Clinical Oncology 15, no. 4 (2021): 202. https://doi.org/10.3892/mco.2021.2364