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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2021 Volume 15 Issue 5

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Case Report

Adult adrenal neuroblastoma: A case report

  • Authors:
    • Shenghan Xu
    • Wenjun Zhang
    • Bangwei Che
    • Jinjuan Zhang
    • Jun He
    • Dongdong Liu
    • Pan Chen
    • Yi Mu
    • Kehang Chen
    • Kaifa Tang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China
  • Article Number: 225
    |
    Published online on: September 1, 2021
       https://doi.org/10.3892/mco.2021.2378
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Abstract

Adrenal neuroblastoma (NB) is very rare in adults. According to the literature, <100 cases have been reported worldwide to date, with >90% of the patients aged <10 years. As the early symptoms of the disease are not obvious, distant metastasis has often already occurred when the patients develop clinical symptoms. This lack of obvious symptoms may lead to misdiagnosis and inadequate treatment. Imaging and laboratory examinations are crucial for the diagnosis of NB, but reaching a definitive diagnosis prior to surgery is challenging, as the final diagnosis ultimately depends on histopathological examination. The aim of the present study was to report the rare case of a 40‑year‑old woman with adrenal left NB who underwent tumor resection. No tumor recurrence was observed at the 3‑month and 1‑year postoperative follow‑up, but a repeat computed tomography at the 3‑year postoperative follow‑up indicated metastases; the patient refused further treatment and eventually succumbed to the disease within 1 month. The aim of the present case was to emphasize the importance of individualized therapy and long‑term, close follow‑up of the patients. The clinical characteristics and treatment of this case of adrenal NB were also summarized and analyzed in order to raise clinical awareness of this rare disease.
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1 

Zhang H and Feng Z: Adrenal neuroblastoma in an elderly adult: A case report and review of the literature. J Med Case Rep. 13(284)2019.PubMed/NCBI View Article : Google Scholar

2 

Bosse KR and Maris JM: Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations. Cancer. 122:20–33. 2016.PubMed/NCBI View Article : Google Scholar

3 

Conter HJ, Gopalakrishnan V, Ravi V, Ater JL, Patel S and Araujo DM: Adult versus pediatric neuroblastoma: The M.D. Anderson cancer center experience. Sarcoma. 2014(375151)2014.PubMed/NCBI View Article : Google Scholar

4 

Bar-Sever Z, Biassoni L, Shulkin B, Kong G, Hofman MS, Lopci E, Manea I, Koziorowski J, Castellani R, Boubaker A, et al: Guidelines on nuclear medicine imaging in neuroblastoma. Eur J Nucl Med Mol Imaging. 45:2009–2024. 2018.PubMed/NCBI View Article : Google Scholar

5 

Zhuang B, Lv DK, Gao SJ and Meng JJ: Differential diagnosis of CT images in children with neuroblastomas and ganglioneuroblastomas. Asian Pac J Cancer Prev. 15:10509–10512. 2014.PubMed/NCBI View Article : Google Scholar

6 

D'Amuri FV, Maestroni U, Pagnini F, Russo U, Melani E, Ziglioli F, Negrini G, Cella S, Cappabianca S, Reginelli A, et al: Magnetic resonance imaging of adrenal gland: State of the art. Gland Surg. 8 (Suppl 3):S223–S232. 2019.PubMed/NCBI View Article : Google Scholar

7 

Simon T: Neuroblastoma. Urologe. A 44:543–554, 555. 2005.PubMed/NCBI View Article : Google Scholar : (In German).

8 

Candito M, Billaud E, Chauffert M, Cottet-Emard JM, Desmoulin D, Garnier JP, Greffe J, Hirth C, Jacob N, Millot F, et al: Biochemical diagnosis of pheochromocytoma and neuroblastomas. Ann Biol Clin (Paris). 60:15–36. 2002.PubMed/NCBI(In French).

9 

Leung FY and Griffiths J: Use of plasma catecholamine values in diagnosing pheochromocytoma and neuroblastoma. Can Med Assoc J. 111:1321–1322. 1974.PubMed/NCBI

10 

Cohn SL, Pearson AD, London WB, Monclair T, Ambros PF, Brodeur GM, Faldum A, Hero B, Iehara T, Machin D, et al: The international neuroblastoma risk group (INRG) classification system: An INRG task force report. J Clin Oncol. 27:289–297. 2009.PubMed/NCBI View Article : Google Scholar

11 

International Pediatric Endosurgery Group. IPEG guidelines for the surgical treatment of adrenal masses in children. J Laparoendosc Adv Surg Tech A. 20:vii–ix. 2010.PubMed/NCBI View Article : Google Scholar

12 

Rogowitz E, Babiker HM, Kanaan M, Millius RA, Ringenberg QS and Bishop M: Neuroblastoma of the elderly, an oncologist's nightmare: Case presentation, literature review and SEER database analysis. Exp Hematol Oncol. 3(20)2014.PubMed/NCBI View Article : Google Scholar

13 

Kushner BH, Kramer K, LaQuaglia MP, Modak S and Cheung NK: Neuroblastoma in adolescents and adults: The memorial sloan-kettering experience. Med Pediatr Oncol. 41:508–515. 2003.PubMed/NCBI View Article : Google Scholar

14 

Yalçin B, Kremer LC, Caron HN and van Dalen EC: High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma. Cochrane Database Syst Rev: Oct 5, 2013 (Epub ahead of print). doi: 10.1002/14651858.CD006301.pub4.

15 

Ertugrul MS, Nadaroglu H, Nalci OB, Hacimuftuoglu A and Alayli A: Preparation of CoS nanoparticles-cisplatin bio-conjugates and investigation of their effects on SH-SY5Y neuroblastoma cell line. Cytotechnology. 72:885–896. 2020.PubMed/NCBI View Article : Google Scholar

16 

Janoueix-Lerosey I, Lequin D, Brugières L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, et al: Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 455:967–970. 2008.PubMed/NCBI View Article : Google Scholar

17 

Holzhauser S, Lukoseviciute M, Papachristofi C, Vasilopoulou C, Herold N, Wickström M, Kostopoulou ON and Dalianis T: Effects of PI3K and FGFR inhibitors alone and in combination, and with/without cytostatics in childhood neuroblastoma cell lines. Int J Oncol. 58:211–225. 2021.PubMed/NCBI View Article : Google Scholar

18 

Podda MG, Luksch R, Polastri D, Gandola L, Piva L, Collini P, Cefalo G, Terenziani M, Ferrari A, Casanova M, et al: Neuroblastoma in patients over 12 years old: A 20-year experience at the istituto nazionale tumori of milan. Tumori. 96:684–689. 2010.PubMed/NCBI

19 

Salim A, Raitio A, Pizer B, Mullassery D and Losty PD: Neuroblastoma: The association of anatomical tumour site, molecular biology and patient outcomes. ANZ J Surg. 91:1000–1004. 2021.PubMed/NCBI View Article : Google Scholar

20 

Simon T, Hero B, Schulte JH, Deubzer H, Hundsdoerfer P, von Schweinitz D, Fuchs J, Schmidt M, Prasad V, Krug B, et al: 2017 GPOH Guidelines for diagnosis and treatment of patients with neuroblastic tumors. Klin Padiatr. 229:147–167. 2017.PubMed/NCBI View Article : Google Scholar

21 

Bhoopathi P, Pradhan AK, Bacolod MD, Emdad L, Sarkar D, Das SK and Fisher PB: Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin. Oncogene. 38:6781–6793. 2019.PubMed/NCBI View Article : Google Scholar

22 

Wevers NR, Kasi DG, Gray T, Wilschut KJ, Smith B, van Vught R, Shimizu F, Sano Y, Kanda T, Marsh G, et al: A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport. Fluids Barriers CNS. 15(23)2018.PubMed/NCBI View Article : Google Scholar

23 

Aldewachi H, Al-Zidan RN, Conner MT and Salman MM: High-Throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases. Bioengineering (Basel). 8(30)2021.PubMed/NCBI View Article : Google Scholar

24 

Salman MM, Marsh G, Kusters I, Delincé M, Di Caprio G, Upadhyayula S, de Nola G, Hunt R, Ohashi KG, Gray T, et al: Design and validation of a human brain endothelial Microvessel-on-a-Chip open microfluidic model enabling advanced optical imaging. Front Bioeng Biotechnol. 8(573775)2020.PubMed/NCBI View Article : Google Scholar

25 

Wang H: Modeling neurological diseases with human brain organoids. Front Synaptic Neurosci. 10(15)2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Xu S, Zhang W, Che B, Zhang J, He J, Liu D, Chen P, Mu Y, Chen K, Tang K, Tang K, et al: Adult adrenal neuroblastoma: A case report. Mol Clin Oncol 15: 225, 2021.
APA
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D. ... Tang, K. (2021). Adult adrenal neuroblastoma: A case report. Molecular and Clinical Oncology, 15, 225. https://doi.org/10.3892/mco.2021.2378
MLA
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D., Chen, P., Mu, Y., Chen, K., Tang, K."Adult adrenal neuroblastoma: A case report". Molecular and Clinical Oncology 15.5 (2021): 225.
Chicago
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D., Chen, P., Mu, Y., Chen, K., Tang, K."Adult adrenal neuroblastoma: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 225. https://doi.org/10.3892/mco.2021.2378
Copy and paste a formatted citation
x
Spandidos Publications style
Xu S, Zhang W, Che B, Zhang J, He J, Liu D, Chen P, Mu Y, Chen K, Tang K, Tang K, et al: Adult adrenal neuroblastoma: A case report. Mol Clin Oncol 15: 225, 2021.
APA
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D. ... Tang, K. (2021). Adult adrenal neuroblastoma: A case report. Molecular and Clinical Oncology, 15, 225. https://doi.org/10.3892/mco.2021.2378
MLA
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D., Chen, P., Mu, Y., Chen, K., Tang, K."Adult adrenal neuroblastoma: A case report". Molecular and Clinical Oncology 15.5 (2021): 225.
Chicago
Xu, S., Zhang, W., Che, B., Zhang, J., He, J., Liu, D., Chen, P., Mu, Y., Chen, K., Tang, K."Adult adrenal neuroblastoma: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 225. https://doi.org/10.3892/mco.2021.2378
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