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Case Report Open Access

Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report

  • Authors:
    • Shohei Ueno
    • Masato Uenomachi
    • Hitoshi Kusaba
    • Mamoru Ito
    • Kunihiro Suzuki
    • Hirofumi Ohmura
    • Kenji Tsuchihashi
    • Hiroshi Ariyama
    • Koichi Akashi
    • Eishi Baba
  • View Affiliations / Copyright

    Affiliations: Department of Medicine and Biosystemic Sciences, Faculty of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, Department of Respiratory Medicine, Kyushu University Hospital, Higashi-ku, Fukuoka 812-8582, Japan, Department of Oncology and Social Medicine, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka 812-8582, Japan
    Copyright: © Ueno et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 221
    |
    Published online on: August 25, 2021
       https://doi.org/10.3892/mco.2021.2379
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Abstract

Severe pneumonitis induced by nivolumab, an anti-programmed cell death-1 monoclonal antibody, is a rare but potentially fatal immune-related adverse event. In cases of steroid-refractory pneumonitis, an appropriate therapeutic strategy using anti-tumor necrosis factor‑α (TNF-α) antibody has not been established. A 59-year-old female was diagnosed with hypopharyngeal squamous cell carcinoma. Previous therapies including chemoradiotherapy and throat laryngectomy were performed, but metastatic recurrence appeared in the intrapulmonary and mediastinal lymph nodes. The patient was administered nivolumab. On the 14th day of nivolumab administration, the patient experienced dyspnea and computed tomography of the chest showed multiple consolidations in the right lung. She was diagnosed with nivolumab-induced pneumonitis. Because the pneumonitis was refractory to steroid therapy, she was administered infliximab, and the pneumonitis improved. On the 72nd and 101st days of nivolumab administration, nivolumab-induced pneumonitis re-appeared with an elevated serum TNF-α concentration. In each occurrence of pneumonitis, repetitive administration of infliximab improved the pneumonitis. Repetitive administration of infliximab may be effective for treating recurrent nivolumab-induced pneumonitis that is associated with an increased serum TNF-α concentration.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011.PubMed/NCBI View Article : Google Scholar

2 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015.PubMed/NCBI View Article : Google Scholar

3 

Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008.PubMed/NCBI View Article : Google Scholar

4 

Ferris RL, Blumenschein G Jr, Fayette J, Guigay J, Colevas AD, Licitra L, Harrington K, Kasper S, Vokes EE, Even C, et al: Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 375:1856–1867. 2016.PubMed/NCBI View Article : Google Scholar

5 

Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, et al: Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 372:320–330. 2015.PubMed/NCBI View Article : Google Scholar

6 

Brahmer J, Reckamp KL, Baas P, Crinò L, Eberhardt WE, Poddubskaya E, Antonia S, Pluzanski A, Vokes EE, Holgado E, et al: Nivolumab versus Docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 373:123–135. 2015.PubMed/NCBI View Article : Google Scholar

7 

Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, et al: Nivolumab versus Docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 373:1627–1639. 2015.PubMed/NCBI View Article : Google Scholar

8 

Motzer RJ, Escudier B, McDermott DF, George S, Hammers HJ, Srinivas S, Tykodi SS, Sosman JA, Procopio G, Plimack ER, et al: Nivolumab versus Everolimus in advanced renal-cell carcinoma. N Engl J Med. 373:1803–1813. 2015.PubMed/NCBI View Article : Google Scholar

9 

Kang YK, Boku N, Satoh T, Ryu MH, Chao Y, Kato K, Chung HC, Chen JS, Muro K, Kang WK, et al: Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): A randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 390:2461–2471. 2017.PubMed/NCBI View Article : Google Scholar

10 

Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med. 372:2509–2520. 2015.PubMed/NCBI View Article : Google Scholar

11 

Nishino M, Sholl LM, Hodi FS, Hatabu H and Ramaiya NH: Anti-PD-1-related pneumonitis during cancer immunotherapy. N Engl J Med. 373:288–290. 2015.PubMed/NCBI View Article : Google Scholar

12 

Nishino M, Giobbie-Hurder A, Hatabu H, Ramaiya NH and Hodi FS: Incidence of programmed cell death 1 inhibitor-related pneumonitis in patients with advanced cancer: A systematic review and meta-analysis. JAMA Oncol. 2:1607–1616. 2016.PubMed/NCBI View Article : Google Scholar

13 

Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil K, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, et al: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy: American society of clinical oncology clinical practice guideline. J Clin Oncol. 36:1714–1768. 2018.PubMed/NCBI View Article : Google Scholar

14 

Champiat S, Lambotte O, Barreau E, Belkhir R, Berdelou A, Carbonnel F, Cauquil C, Chanson P, Collins M, Durrbach A, et al: Management of immune checkpoint blockade dysimmune toxicities: A collaborative position paper. Ann Oncol. 27:559–574. 2016.PubMed/NCBI View Article : Google Scholar

15 

Sanchez GO, Jahn K, Savic S, Zippelius A and Läubli H: Treatment of mycophenolate-resistant immune-related organizing pneumonia with infliximab. J Immunother Cancer. 6(85)2018.PubMed/NCBI View Article : Google Scholar

16 

Postow MA, Sidlow R and Hellmann MD: Immune-related adverse events associated with immune checkpoint blockade. N Engl J Med. 378:158–168. 2018.PubMed/NCBI View Article : Google Scholar

17 

Huang Y, Fan H, Li N and Du J: Risk of immune-related pneumonitis for PD1/PD-L1 inhibitors: Systematic review and network meta-analysis. Cancer Med. 8:2664–2674. 2019.PubMed/NCBI View Article : Google Scholar

18 

Yamaguchi T, Shimizu J, Hasegawa T, Horio Y, Inaba Y, Yatabe Y and Hida T: Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: A retrospective analysis. Lung Cancer. 125:212–217. 2018.PubMed/NCBI View Article : Google Scholar

19 

Cui P, Liu Z, Wang G, Ma J, Qian Y, Zhang F, Han C, Long Y, Li Y, Zheng X, et al: Risk factors for pneumonitis in patients treated with anti-programmed death-1 therapy: A case-control study. Cancer Med. 7:4115–4120. 2018.PubMed/NCBI View Article : Google Scholar

20 

Kido H: Influenza virus pathogenicity regulated by host cellular proteases, cytokines and metabolites, and its therapeutic options. Proc Jpn Acad Ser B Phys Biol Sci. 91:351–368. 2015.PubMed/NCBI View Article : Google Scholar

21 

Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, Kammula US, Topalian SL, Sherry RM, Kleiner D, et al: Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol. 24:2283–2289. 2006.PubMed/NCBI View Article : Google Scholar

22 

Johnston RL, Lutzky J, Chodhry A and Barkin JS: Cytotoxic T-lymphocyte-associated antigen 4 antibody-induced colitis and its management with infliximab. Dig Dis Sci. 54:2538–2540. 2009.PubMed/NCBI View Article : Google Scholar

23 

Sawai Y, Katsuya Y, Shinozaki-Ushiku A, Iwasaki A, Fukayama M, Watanabe K and Nagase T: Rapid temporal improvement of pembrolizumab-induced pneumonitis using the anti-TNF-α antibody infliximab. Drug Discov Ther. 13:164–167. 2019.PubMed/NCBI View Article : Google Scholar

24 

Gosset P, Perez T, Lassalle P, Duquesnoy B, Farre JM, Tonnel AB and Capron A: Increased TNF-alpha secretion by alveolar macrophages from patients with rheumatoid arthritis. Am Rev Respir Dis. 143:593–597. 1991.PubMed/NCBI View Article : Google Scholar

25 

Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Kanzaki M, Mizuno S, et al: Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6. Commun Biol. 3(571)2020.PubMed/NCBI View Article : Google Scholar

26 

Zen Y and Yeh MM: Hepatotoxicity of immune checkpoint inhibitors: A histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury. Mod Pathol. 31:965–973. 2018.PubMed/NCBI View Article : Google Scholar

27 

Minor DR, Chin K and Kashani-Sabet M: . Infliximab in the treatment of anti-CTLA4 antibody (ipilimumab) induced immune-related colitis. Cancer Biother Radiopharm. 24:321–325. 2009.PubMed/NCBI View Article : Google Scholar

28 

Fishman JA, Hogan JI and Maus MV: Inflammatory and infectious syndromes associated with cancer immunotherapies. Clin Infect Dis. 69:909–920. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ueno S, Uenomachi M, Kusaba H, Ito M, Suzuki K, Ohmura H, Tsuchihashi K, Ariyama H, Akashi K, Baba E, Baba E, et al: Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report. Mol Clin Oncol 15: 221, 2021.
APA
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H. ... Baba, E. (2021). Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report. Molecular and Clinical Oncology, 15, 221. https://doi.org/10.3892/mco.2021.2379
MLA
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H., Tsuchihashi, K., Ariyama, H., Akashi, K., Baba, E."Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report". Molecular and Clinical Oncology 15.4 (2021): 221.
Chicago
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H., Tsuchihashi, K., Ariyama, H., Akashi, K., Baba, E."Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 221. https://doi.org/10.3892/mco.2021.2379
Copy and paste a formatted citation
x
Spandidos Publications style
Ueno S, Uenomachi M, Kusaba H, Ito M, Suzuki K, Ohmura H, Tsuchihashi K, Ariyama H, Akashi K, Baba E, Baba E, et al: Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report. Mol Clin Oncol 15: 221, 2021.
APA
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H. ... Baba, E. (2021). Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report. Molecular and Clinical Oncology, 15, 221. https://doi.org/10.3892/mco.2021.2379
MLA
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H., Tsuchihashi, K., Ariyama, H., Akashi, K., Baba, E."Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report". Molecular and Clinical Oncology 15.4 (2021): 221.
Chicago
Ueno, S., Uenomachi, M., Kusaba, H., Ito, M., Suzuki, K., Ohmura, H., Tsuchihashi, K., Ariyama, H., Akashi, K., Baba, E."Improvement in recurring nivolumab-induced pneumonitis with repetitive administration of infliximab in a patient with head and neck cancer: A case report". Molecular and Clinical Oncology 15, no. 4 (2021): 221. https://doi.org/10.3892/mco.2021.2379
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