<em>Leifsonia aquatica</em>: Case report and literature review

De Carvalho,Ricardo Vianna; Santos,Cíntia Silva; Dos Santos Sant'Anna,Louisy Sanches; Lima,Fernanda Ferreira; Júnior,Raphael Hirata; Grabois,Marília Fournaciari; Mattos‑Guaraldi,Ana Luíza

doi:10.3892/mco.2021.2387

Leifsonia aquatica: Case report and literature review

Authors:
- Ricardo Vianna De Carvalho
- Cíntia Silva Santos
- Louisy Sanches Dos Santos Sant'Anna
- Fernanda Ferreira Lima
- Raphael Hirata Júnior
- Marília Fournaciari Grabois
- Ana Luíza Mattos‑Guaraldi
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Affiliations: Pediatric Oncology Surgery Department, National Cancer Center Institute Jose Alencar Gomes da Silva (INCA/RJ), Ministry of Health-Science and Technology, Rio de Janeiro 20230‑130, Brazil, Rio de Janeiro State University, (UERJ), Faculty of Medical Sciences, Discipline of Microbiology and Immunology, Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Rio de Janeiro 20551030, Brazil
Published online on: August 31, 2021 https://doi.org/10.3892/mco.2021.2387
Article Number: 224
Copyright: © De Carvalho et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑diphtheria Corynebacterium species have been increasingly recognized as multidrug resistant pathogens that also infect immunocompromised patients. Automated and semi‑automated phenotypic tests have been used by clinical laboratories for detection of these gram‑positive rods. The present case report describes the rare pediatric case of L. aquatica isolated in central venous catheter blood cultures during chemotherapy treatment for Wilms tumor and adds to the knowledge on this infection with regard to pediatric cancer. The clinical aspects of this patient and opportunities for improving treatment were reviewed. Additionally, a review of the literature revealed no other case report involving cancer and a pediatric patient with documented L. aquatica bacteremia. Corynebacterial infections are considered uncommon, but in recent decades' reports on infection with bacterium are increasing in frequency, particularly in nosocomial immunocompromised patients.

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1	Leal SM Jr, Jones M and Gilligan PH: Clinical significance of commensal gram-positive rods routinely isolated from patient samples. J Clin Microbiol. 54:2928–2936. 2016.PubMed/NCBI View Article : Google Scholar
2	Bernard KA, Pacheco AL, Burdz T and Wiebe D: Increase in detection of Corynebacterium diphtheriae in Canada: 2006-2019. Can Commun Dis Rep. 45:296–301. 2019.PubMed/NCBI View Article : Google Scholar
3	Camello TCF, Mattos-Guaraldi AL, Formiga LCD and Marques EA: Non-diphtherial Corynebacterium species isolated from clinical specimens of patients in a University Hospital, Rio de Janeiro, Brazil. Brazilian J Microbiol. 34:39–44. 2003.
4	Barberis C, Almuzara M, Join-Lambert O, Ramírez MS, Famiglietti A and Vay C: Comparison of the Bruker MALDI-TOF mass spectrometry system and conventional phenotypic methods for identification of Gram-positive rods. PLoS One. 9(e106303)2014.PubMed/NCBI View Article : Google Scholar
5	Martins CAS, Faria LMD, Souza MC, Camello TCF, Velasco E, Hirata R, Jr Thuler LCS and Mattos-Guaraldi AL: Microbiological and host features associated with corynebacteriosis in cancer patients: A five-year study. Mem Inst Oswaldo Cruz. 104:905–913. 2009.PubMed/NCBI View Article : Google Scholar
6	CLSI: Performance Standards for Antimicrobial Susceptibility Testing. 474 M100-S27. Clinical and Laboratory Standards Institute, Wayne, PA, 2017.
7	Larsson P, Lundin O and Falsen E: ‘Corynebacterium aquaticum’ wound infection after high-pressure water injection into the foot. Scand J Infect Dis. 28:635–636. 1996.PubMed/NCBI View Article : Google Scholar
8	Bhatnagar S: Management of Wilms' tumor: NWTS vs. SIOP. J Indian Assoc Pediatr Surg. 14:6–14. 2009.PubMed/NCBI View Article : Google Scholar
9	Kieran K and Ehrlich PF: Current surgical standards of care in Wilms tumor. Urol Oncol. 34:13–23. 2016.PubMed/NCBI View Article : Google Scholar
10	Venkatramani R, Malogolowkin MH and Mascarenhas L: Treatment of multiply relapsed wilms tumor with vincristine, irinotecan, temozolomide and bevacizumab. Pediatr Blood Cancer. 61:756–759. 2014.PubMed/NCBI View Article : Google Scholar
11	Carvalho RV, Lima FFDS, Santos CSD, Souza MC, Silva RSD and Mattos-Guaraldi AL: Central venous catheter-related infections caused by Corynebacterium amycolatum and other multiresistant non-diphtherial corynebacteria in paediatric oncology patients. Braz J Infect Dis. 22:347–351. 2018.PubMed/NCBI View Article : Google Scholar
12	Milani RV, Wilt JK, Entwisle J, Hand J, Cazabon P and Bohan JG: Reducing inappropriate outpatient antibiotic prescribing: Normative comparison using unblinded provider reports. BMJ Open Qual. 8(e000351)2019.PubMed/NCBI View Article : Google Scholar
13	Imai M, Kimura Y, Tanno D, Saito K, Honda M, Takano Y, Ohashi K, Toyokawa M, Ohana N, Yamadera Y and Shimura H: Validation of MALDI-TOF MS devices in reanalysis of unidentified pathogenic bacteria detected in blood cultures. Fukushima J Med Sci. 66:103–112. 2020.PubMed/NCBI View Article : Google Scholar
14	Lau SK, Woo PC, Woo GK and Yuen KY: Catheter-related Microbacterium bacteremia identified by 16S rRNA gene sequencing. J Clin Microbiol. 40:2681–2685. 2002.PubMed/NCBI View Article : Google Scholar
15	Moore C and Norton R: Corynebacterium aquaticum septicemia in a neutropenic patient. J Clin Pathol. 48:971–972. 1995.PubMed/NCBI View Article : Google Scholar
16	Weiner M and Werthamer S: Corynebacterium aquaticum Septicemia: Characterization of the Microorganisms. Am J Clin Pathol. 64:378–381. 1975.PubMed/NCBI View Article : Google Scholar
17	Sulpher J, Desjardins M and Lee BC: Central venous catheter-associated Leifsonia aquatica bacteremia in a hemodialysis-dependent patient. Diagn Microbiol Infect Dis. 61:64–66. 2008.PubMed/NCBI View Article : Google Scholar
18	Corona A, Castelli A, Ballone E, Rech R, Colombo R, Ferraris S, Della Porta V and Raimondi F: A case of septic shock secondary to Corynebacterium aquaticum bacteremia occurring in an HIV-infected patient attending a promiscuous thermal SPA. Minerva Anestesiol. 74:213–215. 2008.PubMed/NCBI
19	Porte L, Soto A, Andrighetti D, Dabanch J, Braun S, Saldivia A, Flores JC, Wozniak A, García P and Weitzel T: Catheter-associated bloodstream infection caused by Leifsonia aquatica in a haemodialysis patient: A case report. J Med Microbiol. 61:868–873. 2012.PubMed/NCBI View Article : Google Scholar
20	Adderson EE, Boudreaux JW and Hayden RT: Infections caused by coryneform bacteria in Pediatric Oncology Patients. Pediatr Infect Dis J. 27:136–141. 2008.PubMed/NCBI View Article : Google Scholar
21	Fischer RA, Peters G, Gehrmann J and Jürgens H: Corynebacterium aquaticum septicemia with acute lymphoblastic leukemia. Pediatr Infect Dis. 13:836–837. 1994.PubMed/NCBI View Article : Google Scholar
22	Gardenier JC, Sawyer RG, Sifri CD, Brayman K, Wispelway B and Bonatti H: Peritonitis caused by Haemophilus parainfluenzae, Leifsonia aquatica, and Gordonia spp. in a patient undergoing continuous ambulatory peritoneal dialysis. Surg Infect (Larchmt). 13:409–412. 2012.PubMed/NCBI View Article : Google Scholar
23	Morris AJ, Henderson GK, Bremner DA and Collins JF: Relapsing peritonitis in a patient undergoing continuous ambulatory peritoneal dialysis due to Corynebacterium aquaticum. J Infect. 13:151–156. 1986.PubMed/NCBI View Article : Google Scholar
24	Beckwith DG, Jahre JA and Haggerty S: Isolation of Corynebacterium aquaticum from spinal fluid of an infant with meningitis. J Clin Microbiol. 23:375–376. 1986.PubMed/NCBI View Article : Google Scholar
25	Casella P, Bosoni MA and Tommasi A: Recurrent Corynebacterium aquaticum peritonitis in a patient undergoing continuous ambulatory peritoneal dialysis. Clin Microbiol Newsl. 10:62–63. 1988.
26	Han L, Lei JE, Wang X, Guo LT, Kang QY, He L and Xu JR: Septicemia caused by Leifsonia aquatica in a healthy patient after retinal reattachment surgery. J Clin Microbiol. 51:3886–3888. 2013.PubMed/NCBI View Article : Google Scholar
27	Tendler C and Bottone EJ: Corynebacterium aquaticum urinary tract infection in a neonate and concepts regarding the role of the organism as a neonatal pathogen. Clin Microbiol. 27:343–345. 1989.PubMed/NCBI View Article : Google Scholar
28	Levitski-Heikkila TV and Ullian ME: Peritonitis with multiple rare environmental bacteria in a patient receiving long-term peritoneal dialysis. Am J Kidney Dis. 46:e119–e124. 2005.PubMed/NCBI View Article : Google Scholar
29	Giammanco GM, Pignato S, Grimont PA, Grimont F, Santangelo C, Leonardi G, Giuffrida A, Legname V and Giamanco G: Interstitial pulmonary inflammation due to Microbacterium sp. after heart transplantation. J Med Microbiol. 55:335–339. 2006.PubMed/NCBI View Article : Google Scholar
30	Fujinaga S, Ohtomo Y, Hirano D, Nishizaki N, Someya T, Ohtsuke Y, Kaneko K and Shimizu T: Relapsing peritonitis with Corynebacterium aquaticum in a boy receiving automated peritoneal dialysis. Pediatr Nephrol. 24:1253–1254. 2009.PubMed/NCBI View Article : Google Scholar
31	Yang K, Kruse RL, Lin WV and Musher DM: Corynebacteria as a cause of pulmonary infection: A case series and literature review. Pneumonia (Nathan). 5(10)2018.PubMed/NCBI View Article : Google Scholar
32	Riebel W, Frantz N, Adelstein D and Spagnuolo PJ: Corynebacterium JK: A cause of nosocomial device-related infection. Rev Infect Dis. 8:42–49. 1986.PubMed/NCBI View Article : Google Scholar
33	Darouiche RO, Dhir A, Miller AJ, Landon GC, Raad II and Musher DM: Vancomycin penetration into biofilm covering infected prostheses and effect on bacteria. J Infect Dis. 170:720–723. 1994.PubMed/NCBI View Article : Google Scholar
34	Ghide S, Jiang Y, Hachem R, Chaftari AM and Raad I: Catheter related Corynebacterium bacterium bacteremia: Should the catheter be removed and vancomycin administered? Euro J Clin Microbiol Infect Dis. 29:153–156. 2010.PubMed/NCBI View Article : Google Scholar
35	Yanai M, Ogasawasa M, Hayashi Y, Suzuki K, Takahashi H and Satomura A: Retrospective evoluation of the clinical characteristics associated with Corynebacterium species bacteremia. Braz J Infect Dis. 22:24–29. 2018.PubMed/NCBI View Article : Google Scholar