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Case Report Open Access

Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report

  • Authors:
    • Anton Straub
    • Christian Linz
    • Sabrina Strobel
    • Stefan Hartmann
    • Julian Hohm
    • Andreas Fuchs
    • Urs Müller‑Richter
    • Alexander Kübler
    • Roman Brands
  • View Affiliations / Copyright

    Affiliations: Department of Maxillofacial and Plastic Surgery of The University of Wuerzburg, D‑97070 Wuerzburg, Germany, Institute of Pathology of The University of Wuerzburg, D‑97080 Wuerzburg, Germany
    Copyright: © Straub et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 226
    |
    Published online on: September 6, 2021
       https://doi.org/10.3892/mco.2021.2389
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Abstract

Mammary analogue secretory carcinoma (MASC) is a rare malignant tumour of the salivary glands, with only few cases reported in the literature to date. Initial preoperative staging is crucial for all patients with an oral malignancy to visualize the tumour, detect lymph node or distant metastases and plan therapeutic interventions. In the case presented herein, radiological imaging revealed a tumour of the right hard palate with suspected positive contralateral lymph nodes. Therefore, local tumour resection comprising hemimaxillectomy and bilateral neck dissection was performed. The diagnosis of MASC was finally based on characteristic histopathological and immunohistochemical findings, such as S100 protein and mammaglobin positivity. The diagnosis of MASC may be challenging, as such findings lack specificity. To confirm the diagnosis, molecular genetic examinations may be performed to detect a highly specific ETV6‑NTRK3 fusion gene. Depending on the results of these examinations, surgery, alone or combined with adjuvant radiation or chemoradiation, is the recommended approach. In summary, MASC should be treated similarly to other low‑grade salivary gland tumours, such as acinic cell carcinoma, as they exhibit biological and histopathological similarities.
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Copy and paste a formatted citation
Spandidos Publications style
Straub A, Linz C, Strobel S, Hartmann S, Hohm J, Fuchs A, Müller‑Richter U, Kübler A and Brands R: Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report. Mol Clin Oncol 15: 226, 2021.
APA
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A. ... Brands, R. (2021). Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report. Molecular and Clinical Oncology, 15, 226. https://doi.org/10.3892/mco.2021.2389
MLA
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A., Müller‑Richter, U., Kübler, A., Brands, R."Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report". Molecular and Clinical Oncology 15.5 (2021): 226.
Chicago
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A., Müller‑Richter, U., Kübler, A., Brands, R."Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 226. https://doi.org/10.3892/mco.2021.2389
Copy and paste a formatted citation
x
Spandidos Publications style
Straub A, Linz C, Strobel S, Hartmann S, Hohm J, Fuchs A, Müller‑Richter U, Kübler A and Brands R: Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report. Mol Clin Oncol 15: 226, 2021.
APA
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A. ... Brands, R. (2021). Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report. Molecular and Clinical Oncology, 15, 226. https://doi.org/10.3892/mco.2021.2389
MLA
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A., Müller‑Richter, U., Kübler, A., Brands, R."Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report". Molecular and Clinical Oncology 15.5 (2021): 226.
Chicago
Straub, A., Linz, C., Strobel, S., Hartmann, S., Hohm, J., Fuchs, A., Müller‑Richter, U., Kübler, A., Brands, R."Mammary analogue secretory carcinoma of a salivary gland of the hard palate with contralateral cervical lymph node metastases: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 226. https://doi.org/10.3892/mco.2021.2389
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