Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2021 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers

  • Authors:
    • Masaaki Ito
    • Takaki Hiwasa
    • Yoko Oshima
    • Satoshi Yajima
    • Takashi Suzuki
    • Tatsuki Nanami
    • Makoto Sumazaki
    • Fumiaki Shiratori
    • Kimihiko Funahashi
    • Hirotaka Takizawa
    • Koichi Kashiwado
    • Naobumi Tochigi
    • Hideaki Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, Toho University Graduate School of Medicine, Ota‑ku, Tokyo 143‑8541, Japan, Department of Gastroenterological Surgery, Toho University School of Medicine, Ota‑ku, Tokyo 143‑8541, Japan, Port Square Kashiwado Clinic, Kashiwado Memorial Foundation, Chuo-ku, Chiba 260‑0025, Japan, Department of Neurology, Kashiwado Hospital, Chuo-ku, Chiba 260‑0854, Japan, Department of Surgical Pathology, Toho University School of Medicine, Ota‑ku, Tokyo 143‑8541, Japan
  • Article Number: 237
    |
    Published online on: September 20, 2021
       https://doi.org/10.3892/mco.2021.2399
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Solid cancers have a poor prognosis, and their morbidity and mortality after surgery is high. Even after radical surgery for esophageal cancer, there have been cases of early postoperative death. The present study therefore aimed to explore new tumor markers that can predict the early postoperative prognosis. To identify antibody markers, serological antigens were identified using recombinant cDNA expression cloning (SEREX). The results identified striatin 4 (STRN4) as the antigen recognized by serum IgG antibodies in patients with esophageal cancer. After performing an amplified luminescence proximity homogeneous assay‑linked immunosorbent assay (AlphaLISA), it was revealed that when compared with healthy donors, serum anti‑STRN4 antibody (STRN4‑Ab) levels were significantly higher not only in patients with esophageal cancer but also to lesser extent, in those with gastric cancer, colorectal cancer, lung cancer and breast cancer. Compared with STRN4‑Ab‑negative patients with esophageal cancer, STRN4‑Ab‑positive patients had a poorer postoperative prognosis at early stages, suggesting that STRN4‑Abs may be useful for predicting poor early‑stage prognoses of patients with esophageal cancer. The positive diagnosis rates of esophageal cancer using the STRN4‑Ab marker and conventional markers, including squamous cell carcinoma antigen and p53 antibody alone, were 26.4, 35.2 and 19.1% respectively; a result that increased up to 59.1% by combining all three markers. Serum STRN4‑Ab may serve as a novel marker of esophageal cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Shimada H: Revisiting radiation therapy for esophageal cancer. Esophagus. 17(99)2020.PubMed/NCBI View Article : Google Scholar

2 

Yang B, Liu Y, Li L, Deng H and Xian L: MicroRNA-200a promotes esophageal squamous cell carcinoma cell proliferation, migration and invasion through extensive target genes. Mol Med Rep. 21:2073–2084. 2020.PubMed/NCBI View Article : Google Scholar

3 

Fernandes E, Sores J, Cotton S, Peixoto A, Ferreira D, Freitas R, Reis CA, Santos LL and Ferreira JA: Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology. Theranostics. 31:4903–4928. 2020.PubMed/NCBI View Article : Google Scholar

4 

Shimada H, Takeda A, Arima M, Okazumi S, Matsubara H, Nabeya Y, Funami Y, Hayashi H, Gunji Y, Suzuki T, et al: Serum p53 antibody is a useful tumor marker in superficial esophageal squamous cell carcinoma. Cancer. 89:1677–1683. 2000.PubMed/NCBI

5 

Kochi R, Yajima S, Nanami T, Suzuki T, Oshima Y, Tokura N, Takatsuka J, Funahashi K, Tochigi N and Shimada H: Five-year postsurgical monitoring of serum p53 antibody for locally advanced esophageal squamous cell carcinoma. Clin J Gastroenterol. 11:278–281. 2018.PubMed/NCBI View Article : Google Scholar

6 

Suzuki T, Yajima S, Ishioka N, Nanami T, Oshima Y, Washizawa N, Funahashi K, Otsuka S, Nemoto T and Shimada H: Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma. Esophagus. 15:294–300. 2018.PubMed/NCBI View Article : Google Scholar

7 

Ito M, Yajima S, Suzuki T, Oshima Y, Nanami T, Sumazaki M, Shiratori F, Funahashi K, Tochigi N and Shimada H: High serum PD-L1 level is a poor prognostic biomarker in surgically treated esophageal cancer. Cancer Med. 9:1321–1327. 2020.PubMed/NCBI View Article : Google Scholar

8 

Ito M, Oshima Y, Yajima S, Suzuki T, Nanami T, Shiratori F, Funahashi K, Nemoto T and Shimada H: Is high serum programmed death ligand 1 level a risk factor for poor survival in patients with gastric cancer? Ann Gastroenterol Surg. 2:313–318. 2018.PubMed/NCBI View Article : Google Scholar

9 

Ito M, Oshima Y, Yajima S, Suzuki T, Nanami T, Shiratori F, Funahashi K and Shimada H: Diagnostic impact of high serum midkine level in patients with gastric cancer. Ann Gastroenterol Surg. 3:195–201. 2019.PubMed/NCBI View Article : Google Scholar

10 

Oshima Y, Shimada H, Yajima S, Nanami T, Matsushita K, Nomura F, Kainuma O, Takiguchi N, Soda H, Ueda T, et al: NY-ESO-1 autoantibody as a tumor-specific biomarker for esophageal cancer: Screening in 1969 patients with various cancers. J Gastroenterol. 51:30–34. 2016.PubMed/NCBI View Article : Google Scholar

11 

Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I and Pfreundschuh M: Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA. 92:11810–11813. 1995.PubMed/NCBI View Article : Google Scholar

12 

Cancer Immunome Database: Available from: http://www2.licr.org/CancerImmunomeDB/.

13 

Nakashima K, Shimada H, Ochiai T, Kuboshima M, Kuroiwa N, Okazumi S, Matsubara H, Nomura F, Takiguchi M and Hiwasa T: Serological identification of TROP2 by recombinant cDNA expression cloning using sera of patients with esophageal squamous cell carcinoma. Int J Cancer. 112:1029–1035. 2004.PubMed/NCBI View Article : Google Scholar

14 

Kuboshima M, Shimada H, Liu TL, Nakashima K, Nomura F, Takiguchi M, Hiwasa T and Ochiai T: Identification of a novel SEREX antigen, SLC2A1/GLUT1, in esophageal squamous cell carcinoma. Int J Oncol. 28:463–468. 2006.PubMed/NCBI

15 

Kuboshima M, Shimada H, Liu TL, Nomura F, Takiguchi M, Hiwasa T and Ochiai T: Presence of serum tripartite motif-containing 21 antibodies in patients with esophageal squamous cell carcinoma. Cancer Sci. 97:380–386. 2006.PubMed/NCBI View Article : Google Scholar

16 

Shimada H, Kuboshima M, Shiratori T, Nabeya Y, Takeuchi A, Takagi H, Nomura F, Takiguchi M, Ochiai T and Hiwasa T: Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. Int J Oncol. 30:97–103. 2007.PubMed/NCBI

17 

Shimada H, Shiratori T, Yasuraoka M, Kagaya A, Kuboshima M, Nomura F, Takiguchi M, Ochiai T, Matsubara H and Hiwasa T: Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma. BMC Cancer. 9(232)2009.PubMed/NCBI View Article : Google Scholar

18 

Kagaya A, Shimada H, Shiratori T, Kuboshima M, Nakashima-Fujita K, Yasuraoka M, Nishimori T, Kurei S, Hachiya T, Murakami A, et al: Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. Proteome Sci. 9(31)2011.PubMed/NCBI View Article : Google Scholar

19 

Japan Esophageal Society. Japanese Classification of Esophageal Cancer, 11th Edition: Part I. Esophagus. 14:1–36. 2017.PubMed/NCBI View Article : Google Scholar

20 

Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition Japanese Gastric Cancer Association. Gastric Cancer. 14:101–112. 2011.PubMed/NCBI View Article : Google Scholar

21 

Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: The 3d English Edition [Secondary Publication]. J Anus Rectum Colon. 3:175–195. 2019.PubMed/NCBI View Article : Google Scholar

22 

Shimada H, Kagaya A, Shiratori T, Nomura F, Takiguchi M, Matsubara H and Hiwasa T: Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma: A possible new serum marker for esophageal cancer. J Gastroenterol. 44:691–696. 2009.PubMed/NCBI View Article : Google Scholar

23 

Matsutani T, Hiwasa T, Takiguchi M, Oide T, Kunimatsu M, Saeki N and Iwadate Y: Autologous antibody to Src-homology 3-domain GRB2-like 1 specifically increases in the sera of patients with low-grade gliomas. J Exp Clin Cancer Res. 31(85)2012.PubMed/NCBI View Article : Google Scholar

24 

Machida T, Kubota M, Kobayashi E, Iwadate Y, Saeki N, Yamaura A, Nomura F, Takiguchi M and Hiwasa T: Identification of stroke-associated-antigens via screening of recombinant proteins from the human expression cDNA library (SEREX). J Transl Med. 13(71)2015.PubMed/NCBI View Article : Google Scholar

25 

Yoshida Y, Wang H, Hiwasa T, Machida T, Kobayashi E, Mine S, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, et al: Elevation of autoantibody level against PDCD11 in patients with transient ischemic attack. Oncotarget. 9:8836–8848. 2017.PubMed/NCBI View Article : Google Scholar

26 

Wang H, Zhang XM, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kimura R, Mine S, Kamitsukasa I, Wada T, et al: Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction. Oncotarget. 9:5600–5613. 2017.PubMed/NCBI View Article : Google Scholar

27 

Kobayashi S, Hiwasa T, Ishige T, Rahmutulla B, Kano M, Hoshino T, Minamoto T, Shimada H, Nomura F, Matsubara H and Matsushita K: Anti-FIRΔexon2, a splicing variant form of PUF60, autoantibody is detected in the sera of esophageal squamous cell carcinoma. Cancer Sci. 110:2004–2013. 2019.PubMed/NCBI View Article : Google Scholar

28 

Hiwasa T, Machida T, Zhang XM, Kimura R, Wang H, Iwase K, Ashino H, Taira A, Arita E, Mine S, et al: Elevated levels of autoantibodies against ATP2B4 and BMP-1 in sera of patients with atherosclerosis-related diseases. Immunome Res. 11(97)2015.

29 

Hiwasa T, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Kunimatsu M, Mine S, Machida T, Sato E, Takemoto M, et al: Serum SH3BP5-specific antibody level is a biomarker of atherosclerosis. Immunome Res. 13(132)2017.

30 

Shimada H, Ochiai T and Nomura F: Japan p53 Antibody Research Group. Titration of serum p53 antibodies in 1,085 patients with various types of malignant tumors: A multiinstitutional analysis by the Japan p53 Antibody Research Group. Cancer. 97:682–689. 2003.PubMed/NCBI View Article : Google Scholar

31 

Shimada H, Nabeya Y, Okazumi S, Matsubara H, Shiratori T, Gunji Y, Kobayashi S, Hayashi H and Ochiai T: Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery. 133:486–494. 2003.PubMed/NCBI View Article : Google Scholar

32 

Kanda Y: Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 48:452–458. 2013.PubMed/NCBI View Article : Google Scholar

33 

Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G and Monneron A: A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons. J Cell Biol. 134:1051–1062. 1996.PubMed/NCBI View Article : Google Scholar

34 

Muro Y, Chan EK, Landberg G and Tan EM: A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells. Biochem Biophys Res Commun. 207:1029–1037. 1995.PubMed/NCBI View Article : Google Scholar

35 

Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG and Monneron A: Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain. J Biol Chem. 275:19970–19977. 2000.PubMed/NCBI View Article : Google Scholar

36 

Janssens V and Goris J: Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J. 353(417)2001.PubMed/NCBI View Article : Google Scholar

37 

Hoof CV and Goris J: Phosphatases in apoptosis: To be or not to be, PP2A is in the heart of the question. Biochim Biophys Acta. 1640:97–104. 2003.PubMed/NCBI View Article : Google Scholar

38 

Wong M, Hyodo T, Asano E, Funasaka K, Miyahara R, Hirooka Y, Goto H, Hamaguchi M and Senga T: Silencing of STRN4 suppresses the malignant characteristics of cancer cells. Cancer Sci. 105:1526–1532. 2014.PubMed/NCBI View Article : Google Scholar

39 

Wang Z, Li Y, Cao J, Zhang W, Wang Q, Zhang Z, Gao Z, Ye Y, Jiang K and Wang S: MicroRNA profile identifies miR-6165 could suppress gastric cancer migration and invasion by targeting STRN4. Onco Targets Ther. 13:1859–1869. 2020.PubMed/NCBI View Article : Google Scholar

40 

Jiang F, Zheng Q, Chang L, Li X, Wang X and Gu X: Pro-oncogene pokemon promotes prostate cancer progression by inducing STRN4 expression. J Cancer. 10:1833–1845. 2019.PubMed/NCBI View Article : Google Scholar

41 

The Human Protein Atlas:Available from: https://www.proteinatlas.org/ENSG00000090372-STRN4/pathology.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ito M, Hiwasa T, Oshima Y, Yajima S, Suzuki T, Nanami T, Sumazaki M, Shiratori F, Funahashi K, Takizawa H, Takizawa H, et al: Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers. Mol Clin Oncol 15: 237, 2021.
APA
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T. ... Shimada, H. (2021). Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers. Molecular and Clinical Oncology, 15, 237. https://doi.org/10.3892/mco.2021.2399
MLA
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T., Sumazaki, M., Shiratori, F., Funahashi, K., Takizawa, H., Kashiwado, K., Tochigi, N., Shimada, H."Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers". Molecular and Clinical Oncology 15.5 (2021): 237.
Chicago
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T., Sumazaki, M., Shiratori, F., Funahashi, K., Takizawa, H., Kashiwado, K., Tochigi, N., Shimada, H."Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers". Molecular and Clinical Oncology 15, no. 5 (2021): 237. https://doi.org/10.3892/mco.2021.2399
Copy and paste a formatted citation
x
Spandidos Publications style
Ito M, Hiwasa T, Oshima Y, Yajima S, Suzuki T, Nanami T, Sumazaki M, Shiratori F, Funahashi K, Takizawa H, Takizawa H, et al: Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers. Mol Clin Oncol 15: 237, 2021.
APA
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T. ... Shimada, H. (2021). Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers. Molecular and Clinical Oncology, 15, 237. https://doi.org/10.3892/mco.2021.2399
MLA
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T., Sumazaki, M., Shiratori, F., Funahashi, K., Takizawa, H., Kashiwado, K., Tochigi, N., Shimada, H."Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers". Molecular and Clinical Oncology 15.5 (2021): 237.
Chicago
Ito, M., Hiwasa, T., Oshima, Y., Yajima, S., Suzuki, T., Nanami, T., Sumazaki, M., Shiratori, F., Funahashi, K., Takizawa, H., Kashiwado, K., Tochigi, N., Shimada, H."Identification of serum anti‑striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers". Molecular and Clinical Oncology 15, no. 5 (2021): 237. https://doi.org/10.3892/mco.2021.2399
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team