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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2021 Volume 15 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Case Report

Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report

  • Authors:
    • Hitomi Matsukawa
    • Nami Ota
    • Kaho Nishioka
    • Tomoko Noguchi
    • Naoyuki Iwahashi
    • Yasushi Mabuchi
    • Shigetaka Yagi
    • Sawako Minami
    • Kazuhiko Ino
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Wakayama Medical University, Wakayama 641‑0012, Japan
  • Article Number: 236
    |
    Published online on: September 20, 2021
       https://doi.org/10.3892/mco.2021.2400
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Abstract

Low‑grade endometrial stromal sarcoma (LG‑ESS) is a rare tumor that mostly occurs in perimenopausal women. Treatment with total hysterectomy and bilateral salpingo‑oophorectomy is recommended, although fertility preservation or ovarian preservation may be considered in younger patients. The present study reports a case of LG‑ESS in a young woman diagnosed after resection of endometrial polyp‑like lesions. A 26‑year‑old nulligravid woman was referred to our hospital after being diagnosed with endometrial polyps. Hysteroscopic endometrial polypectomy was performed twice, and LG‑ESS was suspected on postoperative pathological examination. Magnetic resonance imaging revealed a tumor 5‑cm in diameter on the right side of the uterus. In light of the young age of the patient, tumorectomy was first performed, and postoperative pathological diagnosis was LG‑ESS with the positive resection margin. After thorough discussion with the patient about fertility preservation and recurrence risk, a total abdominal hysterectomy and ovarian preservation was performed. Medroxyprogesterone therapy was performed postoperatively and no recurrence was observed for 2 years.
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1 

Hosh M, Antar S, Nazzal A, Warda M, Gibreel A and Refky B: Uterine sarcoma: Analysis of 13,089 cases based on surveillance, epidemiology and end results database. Int J Gynecol Cancer. 26:1098–1104. 2016.PubMed/NCBI View Article : Google Scholar

2 

Brooks SE, Zhan M, Cote T and Baquet CR: Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol. 93:204–208. 2004.PubMed/NCBI View Article : Google Scholar

3 

Amant F, Coosemans A, Debiec-Rychter M, Timmerman D and Vergote I: Clinical management of uterine sarcomas. Lancet Oncol. 10:1188–1198. 2009.PubMed/NCBI View Article : Google Scholar

4 

Thiel FC and Halmen S: Low-grade endometrial stromal sarcoma-a review. Oncol Res Treat. 41:687–692. 2018.PubMed/NCBI View Article : Google Scholar

5 

Chang KL, Crabtree GS, Lim-Tan SK, Kempson RL and Hendrickson MR: Primary uterine endometrial stromal neoplasms. A clinicopathologic study of 117 cases. Am J Surg Pathol. 14:415–438. 1990.PubMed/NCBI View Article : Google Scholar

6 

Hoang L, Chiang S and Lee CH: Endometrial stromal sarcomas and related neoplasms: New developments and diagnostic considerations. Pathology. 50:162–177. 2018.PubMed/NCBI View Article : Google Scholar

7 

Leath CA III, Huh WK, Hyde J Jr, Cohn DE, Resnick KE, Taylor NP, Powell MA, Mutch DG, Bradley WH, Geller MA, et al: A multi-institutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol. 105:630–634. 2007.PubMed/NCBI View Article : Google Scholar

8 

Riopel J, Plante M, Renaud MC, Roy M and Têtu B: Lymph node metastasis in low-grade endometrial stromal sarcoma. Gynecol Oncol. 96:402–406. 2005.PubMed/NCBI View Article : Google Scholar

9 

Xie W, Cao D, Yang J, Jiang X, Shen K, Pan L, Huang H, Lang J, You Y and Chen J: Fertility-sparing surgery for patients with low-grade endometrial stromal sarcoma. Oncotarget. 8:10602–10608. 2017.PubMed/NCBI View Article : Google Scholar

10 

Laurelli G, Falcone F, Scaffa C, Messalli EM, Del Giudice M, Losito S and Greggi S: Fertility-sparing management of low-grade endometrial stromal sarcoma: Analysis of an institutional series and review of the literature. Eur J Obstet Gynecol Reprod Biol. 195:61–66. 2015.PubMed/NCBI View Article : Google Scholar

11 

Jin Y, Li Y, Deng CY, Tian QJ, Chen H and Pan LY: Fertility-sparing treatment of low-grade endometrial stromal sarcoma. Int J Clin Exp Med. 8:5818–5821. 2015.PubMed/NCBI

12 

Bai H, Yang J, Cao D, Huang H, Xiang Y, Wu M, Cui Q, Chen J, Lang J and Shen K: Ovary and uterus-sparing procedures for low-grade endometrial stromal sarcoma: A retrospective study of 153 cases. Gynecol Oncol. 132:654–660. 2014.PubMed/NCBI View Article : Google Scholar

13 

Amant F, De Knijf A, Van Calster B, Leunen K, Neven P, Berteloot P, Vergote I, Van Huffel S and Moerman P: Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma. Br J Cancer. 97:1194–1199. 2007.PubMed/NCBI View Article : Google Scholar

14 

Berchuck A, Rubin SC, Hoskins WJ, Saigo PE, Pierce VK and Lewis JL Jr: Treatment of endometrial stromal tumors. Gynecol Oncol. 36:60–65. 1990.PubMed/NCBI View Article : Google Scholar

15 

Li N, Wu LY, Zhang HT, An JS, Li XG and Ma SK: Treatment options in stage I endometrial stromal sarcoma: A retrospective analysis of 53 cases. Gynecol Oncol. 108:306–311. 2008.PubMed/NCBI View Article : Google Scholar

16 

Shah JP, Bryant CS, Kumar S, Ali-Fehmi R, Malone JM Jr and Morris RT: Lymphadenectomy and ovarian preservation in low-grade endometrial stromal sarcoma. Obstet Gynecol. 112:1102–1108. 2008.PubMed/NCBI View Article : Google Scholar

17 

Reich O and Regauer S: Aromatase expression in low-grade endometrial stromal sarcomas: An immunohistochemical study. Mod Pathol. 17:104–108. 2004.PubMed/NCBI View Article : Google Scholar

18 

Ushijima K, Yahata H, Yoshikawa H, Konishi I, Yasugi T, Saito T, Nakanishi T, Sasaki H, Saji F, Iwasaka T, et al: Multicenter phase II study of fertility-sparing treatment with medroxyprogesterone acetate for endometrial carcinoma and atypical hyperplasia in young women. J Clin Oncol. 25:2798–1803. 2007.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Matsukawa H, Ota N, Nishioka K, Noguchi T, Iwahashi N, Mabuchi Y, Yagi S, Minami S and Ino K: Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report. Mol Clin Oncol 15: 236, 2021.
APA
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y. ... Ino, K. (2021). Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report. Molecular and Clinical Oncology, 15, 236. https://doi.org/10.3892/mco.2021.2400
MLA
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report". Molecular and Clinical Oncology 15.5 (2021): 236.
Chicago
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 236. https://doi.org/10.3892/mco.2021.2400
Copy and paste a formatted citation
x
Spandidos Publications style
Matsukawa H, Ota N, Nishioka K, Noguchi T, Iwahashi N, Mabuchi Y, Yagi S, Minami S and Ino K: Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report. Mol Clin Oncol 15: 236, 2021.
APA
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y. ... Ino, K. (2021). Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report. Molecular and Clinical Oncology, 15, 236. https://doi.org/10.3892/mco.2021.2400
MLA
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report". Molecular and Clinical Oncology 15.5 (2021): 236.
Chicago
Matsukawa, H., Ota, N., Nishioka, K., Noguchi, T., Iwahashi, N., Mabuchi, Y., Yagi, S., Minami, S., Ino, K."Low‑grade endometrial stromal sarcoma in a young woman diagnosed after resection of endometrial polyp‑like lesions: A case report". Molecular and Clinical Oncology 15, no. 5 (2021): 236. https://doi.org/10.3892/mco.2021.2400
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